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SLC12A1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS177047

Description: Rabbit IgG polyclonal antibody for Solute carrier family 12 member 1(SLC12A1) detection. Tested with WB, IHC-P, IHC-F in Human, Mouse, Rat.Background: Solute carrier family 12(sodium/potassium/chloride transporters), member 1, also called NKCC2… More details

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Product Overview

Online Datasheet in PDF
Product Name
SLC12A1, Polyclonal Antibody
Full Product Name
Anti-SLC12A1 antibody
Product Gene Name
anti-SLC12A1 antibody
Product Synonym Names
Solute carrier family 12 member 1; solute carrier family 12(sodium/potassium/chloride transporters), member 1; BSC1 antibody; Bumetanide sensitive sodium 3 antibody; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 antibody; Kidney specific Na K Cl symporter antibody; Kidney-specific Na-K-Cl symporter antibody; MGC48843 antibody; Na K 2Cl cotransporter antibody; NKCC2 antibody; potassiumchloride cotransporter 2 antibody; S12A1_HUMAN antibody; Slc12a1 antibody; sodium potassium chloride cotransporter 2 antibody; solute carrier family 12(sodium/potassium/chloride transporters) antibody; Solute carrier family 12 member 1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
– Da
OMIM
gene 601678
3D Structure
ModBase 3D Structure for Q13621
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human SLC12A1 (125-139aa KVNRPSLLEIHEQLA), identical to the related mouse sequence, different from the related rat sequence by one amino acid.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-SLC12A1 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin

Immunohistochemistry (IHC) of anti-SLC12A1 antibody

Anti-SLC12A1 antibody, MBS177047, IHC(F)
IHC(F): Rat Kidney Tissue
Rabbit Anti-SLC12A1 Polyclonal Antibody – Cat# MBS177047

Western Blot (WB) of anti-SLC12A1 antibody

Anti-SLC12A1 antibody, MBS177047, Western blotting
WB: Rat Kidney Tissue Lysate
Rabbit Anti-SLC12A1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS177047

Immunohistochemistry (IHC) of anti-SLC12A1 antibody

Anti-SLC12A1 antibody, MBS177047, IHC(P)
IHC(P): Rat Kidney Tissue
Rabbit Anti-SLC12A1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS177047

Other Notes

Small volumes of anti-SLC12A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLC12A1 purchase

MBS177047 is an antibody targeting SLC12A1. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC12A1. It may not necessarily be applicable to this product.

NCBI GI #
212276464
NCBI GeneID
6557
NCBI Accession #
Q13621.2
UniProt Primary Accession #
Q13621
UniProt Secondary Accession #
A8JYA2; E9PDW4
UniProt Related Accession #
Q13621
NCBI Official Full Name
Solute carrier family 12 member 1
NCBI Official Synonym Full Names
solute carrier family 12 (sodium/potassium/chloride transporter), member 1
NCBI Official Symbol
SLC12A1
NCBI Official Synonym Symbols
BSC1; NKCC2
UniProt Protein Name
Solute carrier family 12 member 1
UniProt Synonym Protein Names
Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; Kidney-specific Na-K-Cl symporter
Protein Family
Solute carrier family
UniProt Gene Name
SLC12A1
UniProt Synonym Gene Names
NKCC2
UniProt Entry Name
S12A1_HUMAN
NCBI Protein Information
solute carrier family 12 member 1; NKCC2A variant A; Na-K-2Cl cotransporter; kidney-specific Na-K-Cl symporter; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; solute carrier family 12 (sodium/potassium/chloride transporters), member 1

NCBI Summary for SLC12A1

This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010]
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UniProt Comments for SLC12A1

NKCC2: Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. Kidney specific. Activated by WNK3. Belongs to the SLC12A transporter family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 15q15-q21.1

Cellular Component: membrane; apical plasma membrane; plasma membrane; integral to membrane

Molecular Function: sodium:potassium:chloride symporter activity

Biological Process: transport; sodium ion transport; ion transport; chloride transport; excretion; kidney development; transmembrane transport; potassium ion transport; chemical homeostasis

Disease: Bartter Syndrome, Antenatal, Type 1
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Research Articles on SLC12A1

1. overexpression of mammalian plasma-membrane Na+-K+-2Cl- co-transporter NKCC2 in yeast cells complements the phenotypes resulting from the deletion of the VHC1 gene.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLC12A1 antibody

 Reference Product  PubMed Publications
 AQP2 antibody  >41 publications with SLC12A1 and AQP2
 KCNJ1 antibody  >38 publications with SLC12A1 and KCNJ1
 CLCNKB antibody  >16 publications with SLC12A1 and CLCNKB
 STK39 antibody  >15 publications with SLC12A1 and STK39
 WNK4 antibody  >10 publications with SLC12A1 and WNK4
 BSND antibody  >8 publications with SLC12A1 and BSND
 WNK3 antibody  >6 publications with SLC12A1 and WNK3
 OXSR1 antibody  >2 publications with SLC12A1 and OXSR1

Pathways associated with anti-SLC12A1 antibody

 Products by Pathway  Pathway Diagram
 Cation-coupled Chloride Cotransporters Pathway antibodies  Cation-coupled Chloride Cotransporters Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies  Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram

Diseases associated with anti-SLC12A1 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >74 publications with SLC12A1 and Kidney Diseases
 Hypertension Antibodies  >72 publications with SLC12A1 and Hypertension
 Bartter Syndrome Antibodies  >39 publications with SLC12A1 and Bartter Syndrome
 Disease Models, Animal Antibodies  >27 publications with SLC12A1 and Disease Models, Animal
 Hypokalemia Antibodies  >24 publications with SLC12A1 and Hypokalemia
 Polyuria Antibodies  >18 publications with SLC12A1 and Polyuria
 Nervous System Diseases Antibodies  >13 publications with SLC12A1 and Nervous System Diseases
 Renal Insufficiency Antibodies  >10 publications with SLC12A1 and Renal Insufficiency
 Hypotension Antibodies  >7 publications with SLC12A1 and Hypotension
 Heart Diseases Antibodies  >7 publications with SLC12A1 and Heart Diseases

Organs/Tissues associated with anti-SLC12A1 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >226 publications with SLC12A1 and Kidney
 Vascular Antibodies  >24 publications with SLC12A1 and Vascular
 Brain Antibodies  >14 publications with SLC12A1 and Brain
 Lung Antibodies  >8 publications with SLC12A1 and Lung
 Muscle Antibodies  >7 publications with SLC12A1 and Muscle
 Parathyroid Antibodies  >6 publications with SLC12A1 and Parathyroid
 Intestine Antibodies  >5 publications with SLC12A1 and Intestine
 Liver Antibodies  >5 publications with SLC12A1 and Liver
 Bone Antibodies  >5 publications with SLC12A1 and Bone
 Eye Antibodies  >4 publications with SLC12A1 and Eye
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