Rabbit Anti-HYAL1 Polyclonal Antibody – Cat# MBS177085

Anti-HYAL1 antibody, MBS177085, Western blotting
Lane 1: NRK Cell Lysate
Lane 2: Mouse Liver Tissue Lysate
Lane 3: Mouse Kidney Tissue Lysate
Lane 4: SP2/0 Cell Lysate

HYAL1 Antibody – Rabbit Polyclonal

Name: HYAL1 Antibody; Polyclonal; Rabbit; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS177085
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS177085

Description: Rabbit IgG polyclonal antibody for Hyaluronidase-1(HYAL1) detection. Tested with WB in mouse.Background: Hyaluronidase-1, also known as HYAL1 or LUCA1, is an enzyme that in humans is encoded by the HYAL1 gene. The gene is one of several related… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

HYAL1, Polyclonal Antibody

Full Product Name

Anti-HYAL1 antibody

Product Gene Name

anti-HYAL1 antibody

Product Synonym Names

Hyaluronidase-1; hyaluronoglucosaminidase 1; HYAL 1 antibody; Hyal-1 antibody; HYAL1 antibody; HYAL1_HUMAN antibody; Hyaluronidase 1 antibody; Hyaluronidase-1 antibody; Hyaluronoglucosaminidase 1 antibody; Hyaluronoglucosaminidase-1 antibody; Hyaluronoglucosaminidase1 antibody; LUCA 1 antibody; LUCA-1 antibody; LUCA1 antibody; Lung carcinoma protein 1 antibody; MGC45987 antibody; NAT6 antibody; Plasma hyaluronidase antibody; Tumor suppressor LUCA 1 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Mouse

Form/Format

Lyophilized

Purity/Purification

Immunogen affinity purified.

Preparation and Storage

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Molecular Weight

51,436 Da

3D Structure

ModBase 3D Structure for Q91ZJ9

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of mouse HYAL1 (434-450aa LKDRAQMAMKFRCRCYR), different from the related rat sequence by one amino acid.

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-HYAL1 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-HYAL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HYAL1 purchase

MBS177085 is an antibody targeting HYAL1. Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HYAL1. It may not necessarily be applicable to this product.

NCBI GI #

341941064

NCBI GeneID

15586

NCBI Accession #

Q91ZJ9.3

UniProt Primary Accession #

Q91ZJ9

UniProt Secondary Accession #

O70229; Q8CE62; Q8QZX3; Q8VBW7; Q8VDK0; B1AV90

UniProt Related Accession #

Q91ZJ9

NCBI Official Full Name

Hyaluronidase-1

NCBI Official Synonym Full Names

hyaluronoglucosaminidase 1

NCBI Official Symbol

Hyal1

NCBI Official Synonym Symbols

Hya1; Hyal-1

UniProt Protein Name

Hyaluronidase-1

UniProt Synonym Protein Names

Hyaluronoglucosaminidase-1

UniProt Gene Name

Hyal1

UniProt Synonym Gene Names

Hyal-1

UniProt Entry Name

HYAL1_MOUSE

NCBI Protein Information

hyaluronidase-1; hyaluronidase 1; hyaluronoglucosaminidase-1

UniProt Comments for HYAL1

HYAL1: May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. Defects in HYAL1 are the cause of mucopolysaccharidosis type 9 (MPS9); also called hyaluronidase deficiency. MPS9 is a lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement. Belongs to the glycosyl hydrolase 56 family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; Secreted, signal peptide; EC 3.2.1.35; Glycan Metabolism - glycosaminoglycan degradation; Secreted

Cellular Component: extracellular space; lysosome; cytoplasm; extracellular region; cytoplasmic vesicle

Molecular Function: viral receptor activity; hydrolase activity; hydrolase activity, acting on glycosyl bonds; hyaluronan synthase activity; transcription factor binding; catalytic activity; hyalurononglucosaminidase activity

Biological Process: positive regulation of cell adhesion; metabolic process; response to virus; positive regulation of cell growth; hyaluronan catabolic process; response to antibiotic; response to reactive oxygen species; positive regulation of angiogenesis; hyaluronan biosynthetic process; carbohydrate metabolic process; negative regulation of cell growth; inflammatory response; hyaluronan metabolic process; positive regulation of growth; positive regulation of epithelial cell proliferation

Research Articles on HYAL1

1. The knockdown of Hyal-1 results in an 80% decrease of total acid hyaluronidase activity in the mouse liver, confirming that Hyal-1 is a key actor of hyaluronic acid catabolism in this organ.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HYAL1 antibody

Reference Product	PubMed Publications
Has2 antibody	>25 publications with HYAL1 and Has2
Gusb antibody	>1 publications with HYAL1 and Gusb

Pathways associated with anti-HYAL1 antibody

Products by Pathway	Pathway Diagram
CS/DS Degradation Pathway antibodies	CS/DS Degradation Pathway Diagram
Chondroitin Sulfate Degradation Pathway antibodies	Chondroitin Sulfate Degradation Pathway Diagram
Chondroitin Sulfate Degradation Pathway antibodies	Chondroitin Sulfate Degradation Pathway Diagram
Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies	Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
Dermatan Sulfate Degradation Pathway antibodies	Dermatan Sulfate Degradation Pathway Diagram
Dermatan Sulfate Degradation Pathway antibodies	Dermatan Sulfate Degradation Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Glycogen Storage Diseases Pathway antibodies	Glycogen Storage Diseases Pathway Diagram
Glycosaminoglycan Degradation Pathway antibodies	Glycosaminoglycan Degradation Pathway Diagram
Glycosaminoglycan Degradation Pathway antibodies	Glycosaminoglycan Degradation Pathway Diagram

Diseases associated with anti-HYAL1 antibody

Disease Name	Pubmed Publications
Adenocarcinoma Antibodies	>10 publications with HYAL1 and Adenocarcinoma
Inflammation Antibodies	>9 publications with HYAL1 and Inflammation
Neoplasm Metastasis Antibodies	>9 publications with HYAL1 and Neoplasm Metastasis
Hyaluronidase Deficiency Antibodies	>9 publications with HYAL1 and Hyaluronidase Deficiency
Necrosis Antibodies	>8 publications with HYAL1 and Necrosis
Urinary Bladder Neoplasms Antibodies	>5 publications with HYAL1 and Urinary Bladder Neoplasms
Nervous System Diseases Antibodies	>5 publications with HYAL1 and Nervous System Diseases
Kidney Diseases Antibodies	>4 publications with HYAL1 and Kidney Diseases
Liver Neoplasms Antibodies	>2 publications with HYAL1 and Liver Neoplasms
Hyperplasia Antibodies	>2 publications with HYAL1 and Hyperplasia

Organs/Tissues associated with anti-HYAL1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>19 publications with HYAL1 and Blood
Lung Antibodies	>14 publications with HYAL1 and Lung
Skin Antibodies	>12 publications with HYAL1 and Skin
Joint Antibodies	>9 publications with HYAL1 and Joint
Liver Antibodies	>6 publications with HYAL1 and Liver
Muscle Antibodies	>5 publications with HYAL1 and Muscle
Embryonic Tissue Antibodies	>4 publications with HYAL1 and Embryonic Tissue
Brain Antibodies	>4 publications with HYAL1 and Brain
Spleen Antibodies	>2 publications with HYAL1 and Spleen
Salivary Gland Antibodies	>1 publications with HYAL1 and Salivary Gland