Neuropilin-1 (NRP1) ELISA Kit for Rat

NRP1: The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. Homodimer, and heterodimer with NRP2. Interacts with FER. Binds PLXNB1. The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules. Belongs to the neuropilin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: extracellular space; growth cone; cell surface; focal adhesion; cell soma; axon; early endosome; integral to membrane; plasma membrane; neurofilament; cytosol

Molecular Function: heparin binding; vascular endothelial growth factor receptor activity; protein binding; semaphorin receptor activity; growth factor binding; metal ion binding

Biological Process: axon guidance; facial nerve structural organization; peptidyl-tyrosine phosphorylation; heart development; neuron migration; vestibulocochlear nerve structural organization; platelet-derived growth factor receptor signaling pathway; negative regulation of axon extension; negative regulation of axon extension involved in axon guidance; trigeminal nerve morphogenesis; gonadotrophin-releasing hormone neuronal migration to the hypothalamus; sympathetic nervous system development; positive chemotaxis; branchiomotor neuron axon guidance; response to wounding; dendrite development; angiogenesis; negative regulation of neuron apoptosis; trigeminal nerve structural organization; nervous system development; cell migration; axonal fasciculation; hepatocyte growth factor receptor signaling pathway; axon extension involved in axon guidance; patterning of blood vessels; positive regulation of peptidyl-tyrosine phosphorylation; cell migration during sprouting angiogenesis; otic placode formation; regulation of axon extension involved in axon guidance; positive regulation of axon extension involved in axon guidance; neuron development; artery morphogenesis; nerve development; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; retinal ganglion cell axon guidance