TIMP-2 (TIMP2) ELISA Kit for Rat

TIMP2: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. Interacts (via the C-terminal) with MMP2 (via the C- terminal PEX domain); the interaction inhibits the MMP2 activity. Down-regulated by TGFB1. Belongs to the protease inhibitor I35 (TIMP) family.

Protein type: Inhibitor; Secreted; Motility/polarity/chemotaxis; Extracellular matrix; Secreted, signal peptide; Cell development/differentiation

Cellular Component: extracellular space; proteinaceous extracellular matrix; neuron projection; cell surface; growth cone; cell soma; basement membrane; nucleus

Molecular Function: integrin binding; metalloendopeptidase inhibitor activity; protease binding; metal ion binding; enzyme activator activity

Biological Process: negative regulation of proteolysis; regulation of Rap protein signal transduction; response to drug; positive regulation of catalytic activity; negative regulation of metalloenzyme activity; central nervous system development; regulation of neuron differentiation; regulation of cAMP metabolic process; response to hormone stimulus; negative regulation of membrane protein ectodomain proteolysis; negative regulation of cell proliferation; positive regulation of MAPKKK cascade; response to cytokine stimulus; regulation of MAPKKK cascade; negative regulation of Ras protein signal transduction; negative regulation of mitotic cell cycle; spermatogenesis; positive regulation of adenylate cyclase activity; positive regulation of neuron differentiation; aging