TGF-Beta 3 (TGFB3) ELISA Kit for Mouse

This gene encodes a member of the transforming growth factor (TGF) beta superfamily of cell regulatory proteins that control adhesion, proliferation, differentiation and transformation of many cell types. The encoded protein likely undergoes proteolytic cleavage similar to the human ortholog to generate an active peptide from the C-terminal region (TGF-beta 3), which is rendered inactive by its non-covalent association with the N-terminal peptide called the "Latency-associated peptide." Mice lacking the encoded protein die shortly after birth, and display abnormal pulmonary development and defective palatogenesis. [provided by RefSeq, Jul 2015]

TGFB3: Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family.

Protein type: Motility/polarity/chemotaxis; Secreted; Cell development/differentiation; Secreted, signal peptide; Ligand, receptor tyrosine kinase

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; cell surface; cell soma; cytoplasm; T-tubule; extracellular region; nucleus; secretory granule

Molecular Function: identical protein binding; growth factor activity; transforming growth factor beta binding; protein heterodimerization activity; punt binding; cytokine activity; transforming growth factor beta receptor binding

Biological Process: positive regulation of apoptosis; activation of MAPK activity; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; palate development; SMAD protein nuclear translocation; negative regulation of cell proliferation; mammary gland development; transforming growth factor beta receptor signaling pathway; embryonic neurocranium morphogenesis; negative regulation of neuron apoptosis; cell growth; positive regulation of filopodium formation; intercellular junction assembly and maintenance; in utero embryonic development; embryonic development; organ morphogenesis; positive regulation of protein secretion; negative regulation of DNA replication; response to estrogen stimulus; regulation of MAPKKK cascade; positive regulation of cell division; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; response to progesterone stimulus; alveolus development; positive regulation of DNA replication; growth