TIMP-2 (TIMP2) ELISA Kit for Mouse

TIMP2: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. Interacts (via the C-terminal) with MMP2 (via the C- terminal PEX domain); the interaction inhibits the MMP2 activity. Down-regulated by TGFB1. Belongs to the protease inhibitor I35 (TIMP) family.

Protein type: Inhibitor; Secreted, signal peptide; Secreted; Cell development/differentiation; Motility/polarity/chemotaxis; Extracellular matrix

Cellular Component: extracellular space; neuron projection; cell surface; growth cone; cell soma; extracellular region; basement membrane

Molecular Function: integrin binding; enzyme inhibitor activity; metalloendopeptidase inhibitor activity; protease binding; protease inhibitor activity; metal ion binding; enzyme activator activity

Biological Process: positive regulation of catalytic activity; negative regulation of proteolysis; regulation of Rap protein signal transduction; negative regulation of metalloenzyme activity; regulation of neuron differentiation; regulation of cAMP metabolic process; response to hormone stimulus; negative regulation of peptidase activity; negative regulation of membrane protein ectodomain proteolysis; negative regulation of cell proliferation; positive regulation of MAPKKK cascade; response to cytokine stimulus; regulation of MAPKKK cascade; negative regulation of Ras protein signal transduction; negative regulation of mitotic cell cycle; positive regulation of adenylate cyclase activity; positive regulation of neuron differentiation