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B-Cell Antigen Receptor Complex-Associated Protein Beta Chain (CD79B) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS177477

Description: Rabbit IgG polyclonal antibody for B-cell antigen receptor complex-associated protein beta chain(CD79B) detection. Tested with WB, IHC-P, ICC in Human;Mouse;Rat.Background: CD79b molecule, immunoglobulin-associated beta, also known as CD79B… More details

$210 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
B-cell antigen receptor complex-associated protein beta chain (CD79B), Polyclonal Antibody
Full Product Name
Anti-CD79b Antibody
Product Gene Name
anti-CD79B antibody
Product Synonym Names
AGM6 antibody; B cell antigen receptor complex associated protein beta chain antibody; B cell specific glycoprotein B29 antibody; B-cell antigen receptor complex-associated protein beta chain antibody; B-cell-specific glycoprotein B29 antibody; B29 antibody; B29/Ig-beta/CD79b antibody; CD 79b antibody; CD79b antibody; CD79b antigen (immunoglobulin associated beta) antibody; CD79b antigen antibody; CD79b molecule antibody; CD79b molecule immunoglobulin associated beta antibody; CD79b protein antibody; CD79B_HUMAN antibody; Ig beta antibody; Ig-beta antibody; IGB antibody; Igbeta antibody; Immunoglobulin associated B29 antibody; Immunoglobulin associated B29 protein antibody; Immunoglobulin associated beta antibody; Immunoglobulin associated protein antibody; Immunoglobulin-associated B29 protein antibody; MGC108607 antibody; CD79b molecule, immunoglobulin-associated beta
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat. No cross reactivity with other proteins.
Form/Format
Lyophilized
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
26,119 Da
OMIM
gene 612692
3D Structure
ModBase 3D Structure for P40259
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Immunogen
E.coli-derived human CD79b recombinant protein (Position: A29-E229). Human CD79b shares 70% amino acid (aa) sequence identity with mouse CD79b.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CD79B antibody
Western Blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry (ICC)
Application Notes for anti-CD79B antibody
Western Blot: Concentration: 0.1-0.5mug/ml; Tested Species: Human
Immunohistochemistry (Paraffin-embedded Section): Concentration: 0.5-1mug/ml; Tested Species: Human, Mouse, Rat
Immunohistochemistry (Frozen Section): Concentration: 0.5-1mug/ml; Tested Species: Human

Western Blot (WB) of anti-CD79B antibody

Anti- CD79B picoband antibody, MBS177477, Western blotting
All lanes: Anti CD79B (MBS177477) at 0.5ug/ml
WB: Recombinant Human CD79B Protein 0.5ng
Predicted bind size: 45KD
Observed bind size: 45KD
Rabbit Anti-CD79B Polyclonal Antibody – Cat# MBS177477

Western Blot (WB) of anti-CD79B antibody

Anti- CD79B picoband antibody, MBS177477, Western blotting
All lanes: Anti CD79b (MBS177477) at 0.5ug/ml
Lane 1: Raji Whole Cell Lysate at 40ug
Lane 2: Hl-60 Whole Cell Lysate at 40ug
Lane 3: HUT Whole Cell Lysate at 40ug
Predicted bind size: 26KD
Observed bind size: 35KD
Rabbit Anti-CD79B Polyclonal Antibody, Western Blot (WB) – Cat# MBS177477

Immunohistochemistry (IHC) of anti-CD79B antibody

Anti- CD79B picoband antibody, MBS177477,IHC(P)
IHC(P): Mouse Spleen Tissue
Rabbit Anti-CD79B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS177477

Immunohistochemistry (IHC) of anti-CD79B antibody

Anti- CD79B picoband antibody, MBS177477,IHC(P)
IHC(P): Rat Spleen Tissue
Rabbit Anti-CD79B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS177477

Immunohistochemistry (IHC) of anti-CD79B antibody

Anti- CD79B picoband antibody, MBS177477,IHC(P)
IHC(P): Human Tonsil Tissue
Rabbit Anti-CD79B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS177477

Other Notes

Small volumes of anti-CD79B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD79B purchase

MBS177477 is an antibody targeting CD79B. Reactive in Human, Mouse, Rat. No cross reactivity with other proteins.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD79B. It may not necessarily be applicable to this product.

NCBI GI #
11038674
NCBI GeneID
974
NCBI Accession #
NP_000617.1
UniProt Primary Accession #
P40259
UniProt Secondary Accession #
Q53FS2; Q9BU06
UniProt Related Accession #
P40259
GenBank Nucleotide #
NM_000626.2
NCBI Official Full Name
B-cell antigen receptor complex-associated protein beta chain isoform 1
NCBI Official Synonym Full Names
CD79b molecule, immunoglobulin-associated beta
NCBI Official Symbol
CD79B
NCBI Official Synonym Symbols
B29; IGB; AGM6
UniProt Protein Name
B-cell antigen receptor complex-associated protein beta chain
UniProt Synonym Protein Names
B-cell-specific glycoprotein B29; Ig-beta; Immunoglobulin-associated B29 protein; CD_antigen: CD79b
Protein Family
B-cell antigen receptor complex-associated protein
UniProt Gene Name
CD79B
UniProt Synonym Gene Names
B29; IGB
UniProt Entry Name
CD79B_HUMAN
NCBI Protein Information
B-cell antigen receptor complex-associated protein beta chain; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta)

NCBI Summary for CD79B

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
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UniProt Comments for CD79B

Ig-beta: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6). It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q23

Cellular Component: nucleoplasm; Golgi apparatus; integral to plasma membrane; cytoplasm; plasma membrane; B cell receptor complex; external side of plasma membrane

Molecular Function: transmembrane receptor activity

Biological Process: B cell receptor signaling pathway; immune response; signal transduction

Disease: Agammaglobulinemia 6, Autosomal Recessive
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Research Articles on CD79B

1. results suggest that MYD88 mutations, and to a lesser extent CD79B mutations, are important drivers of lymphomagenesis in PTL

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD79B antibody

 Reference Product  PubMed Publications
 CD79A antibody  >616 publications with CD79B and CD79A
 CD19 antibody  >107 publications with CD79B and CD19
 CD22 antibody  >71 publications with CD79B and CD22
 PTPRC antibody  >49 publications with CD79B and PTPRC
 SYK antibody  >38 publications with CD79B and SYK
 LYN antibody  >25 publications with CD79B and LYN
 FYN antibody  >10 publications with CD79B and FYN
 BTK antibody  >9 publications with CD79B and BTK
 PTPN6 antibody  >4 publications with CD79B and PTPN6
 BLK antibody  >4 publications with CD79B and BLK

Pathways associated with anti-CD79B antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Signaling By The B Cell Receptor (BCR) Pathway antibodies  Signaling By The B Cell Receptor (BCR) Pathway Diagram

Diseases associated with anti-CD79B antibody

 Disease Name  Pubmed Publications
 Lymphoma, Large B-Cell, Diffuse Antibodies  >79 publications with CD79B and Lymphoma, Large B-Cell, Diffuse
 Inflammation Antibodies  >18 publications with CD79B and Inflammation
 Liver Diseases Antibodies  >18 publications with CD79B and Liver Diseases
 Hyperplasia Antibodies  >16 publications with CD79B and Hyperplasia
 Lung Diseases Antibodies  >11 publications with CD79B and Lung Diseases
 Disease Models, Animal Antibodies  >10 publications with CD79B and Disease Models, Animal
 Necrosis Antibodies  >10 publications with CD79B and Necrosis
 Liver Neoplasms Antibodies  >9 publications with CD79B and Liver Neoplasms
 Anemia Antibodies  >7 publications with CD79B and Anemia
 Weight Loss Antibodies  >5 publications with CD79B and Weight Loss

Organs/Tissues associated with anti-CD79B antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >420 publications with CD79B and Blood
 Bone Antibodies  >121 publications with CD79B and Bone
 Lymph Node Antibodies  >91 publications with CD79B and Lymph Node
 Lymph Antibodies  >87 publications with CD79B and Lymph
 Spleen Antibodies  >54 publications with CD79B and Spleen
 Skin Antibodies  >40 publications with CD79B and Skin
 Intestine Antibodies  >23 publications with CD79B and Intestine
 Vascular Antibodies  >20 publications with CD79B and Vascular
 Lung Antibodies  >19 publications with CD79B and Lung
 Thymus Antibodies  >19 publications with CD79B and Thymus
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