Homeobox Protein Hox-A9 (HOXA9) Antibody – Rabbit Polyclonal

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011]

HOXA9: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. A chromosomal aberration involving HOXA9 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with NUP98. A chromosomal aberration involving HOXA9 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with MSI2. Belongs to the Abd-B homeobox family.

Protein type: DNA-binding; Oncoprotein

Chromosomal Location of Human Ortholog: 7p15.2

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus

Molecular Function: protein binding; enzyme binding; sequence-specific DNA binding

Biological Process: embryonic forelimb morphogenesis; negative regulation of myeloid cell differentiation; transcription, DNA-dependent; multicellular organismal development; embryonic skeletal development; male gonad development; uterus development; endothelial cell activation; anterior/posterior pattern formation; mammary gland development; regulation of transcription, DNA-dependent; single fertilization; spermatogenesis; proximal/distal pattern formation