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Transferrin Receptor Protein 1 (TFRC) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS177496

Description: Rabbit IgG polyclonal antibody for Transferrin receptor protein 1(TFRC) detection. Tested with WB, IHC-P in Human.Background: Transferrin receptor protein 1 (TfR1), also known as Cluster of Differentiation 71 (CD71), is a protein that in humans… More details

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Product Overview

Online Datasheet in PDF
Product Name
Transferrin receptor protein 1 (TFRC), Polyclonal Antibody
Full Product Name
Anti-TFRC Antibody
Product Gene Name
anti-TFRC antibody
Product Synonym Names
CD 71 antibody; CD71 antibody; CD71 antigen antibody; OTTHUMP00000208523 antibody; OTTHUMP00000208524 antibody; OTTHUMP00000208525 antibody; p90 antibody; sTfR antibody; T9 antibody; TFR 1 antibody; TFR antibody; TFR1 antibody; TFR1_HUMAN antibody; TFRC antibody; TR antibody; Transferrin receptor (p90 CD71) antibody; Transferrin Receptor Protein 1 antibody; Transferrin receptor protein 1, serum form antibody; TRFR antibody; transferrin receptor
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human. No cross reactivity with other proteins.
Form/Format
Lyophilized
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
84,871 Da
OMIM
190010
3D Structure
ModBase 3D Structure for P02786
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Immunogen
E.coli-derived human TFRC recombinant protein (Position: M1-N198). Human TFRC shares 72% and 70% amino acid (aa) sequences identity with mouse and rat TFRC, respectively.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-TFRC antibody
Western Blot (WB), Immunohistochemistry (IHC-P)
Application Notes for anti-TFRC antibody
Western Blot: Concentration: 0.1-0.5mug/ml; Tested Species: Human
Immunohistochemistry (Paraffin-embedded Section): Concentration: 0.5-1mug/ml; Tested Species: Human

Western Blot (WB) of anti-TFRC antibody

Anti- TFRC antibody, MBS177496, Western blotting
All lanes: Anti TFRC (MBS177496) at 0.5ug/ml
WB: Recombinant Human TRFC Protein 0.5ng
Predicted bind size: 45KD
Observed bind size: 45KD
Rabbit Anti-TFRC Polyclonal Antibody – Cat# MBS177496

Western Blot (WB) of anti-TFRC antibody

Anti- TFRC antibody, MBS177496, Western blotting
All lanes: Anti TRFC (MBS177496) at 0.5ug/ml
Lane 1: HELA Whole Cell Lysate at 40ug
Lane 2: JURAKT Whole Cell Lysate at 40ug
Lane 3: RAJI Whole Cell Lysate at 40ug
Lane 4: HL-60 Whole Cell Lysate at 40ug
Lane 5: K562 Whole Cell Lysate at 40ug
Lane 6: HEPG2 Whole Cell Lysate at 40ug
Lane 7: Human Placenta Tissue Lysate at 50ug
Lane 8: CEM Whole Cell Lysate at 40ug
Predicted bind size: 86KD
Observed bind size: 98KD
Rabbit Anti-TFRC Polyclonal Antibody, Western Blot (WB) – Cat# MBS177496

Immunohistochemistry (IHC) of anti-TFRC antibody

Anti- TFRC antibody, MBS177496,IHC(P)
IHC(P): Human Placenta Tissue
Rabbit Anti-TFRC Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS177496

Other Notes

Small volumes of anti-TFRC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TFRC purchase

MBS177496 is an antibody targeting TFRC. Reactive in Human. No cross reactivity with other proteins.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TFRC. It may not necessarily be applicable to this product.

NCBI GI #
189458819
NCBI GeneID
7037
NCBI Accession #
NP_001121620.1
UniProt Primary Accession #
P02786
UniProt Secondary Accession #
Q1HE24; Q59G55; Q9UCN0; Q9UCU5; Q9UDF9; Q9UK21; D3DXB0
UniProt Related Accession #
P02786
GenBank Nucleotide #
NM_001128148.1
NCBI Official Full Name
transferrin receptor protein 1
NCBI Official Synonym Full Names
transferrin receptor
NCBI Official Symbol
TFRC
NCBI Official Synonym Symbols
T9; TR; TFR; p90; CD71; TFR1; TRFR
UniProt Protein Name
Transferrin receptor protein 1
UniProt Synonym Protein Names
T9; p90; CD_antigen: CD71Transferrin receptor protein 1, serum form; sTfR
Protein Family
Transferrin receptor protein
UniProt Gene Name
TFRC
UniProt Synonym Gene Names
TR; TfR; TfR1; Trfr; sTfR
UniProt Entry Name
TFR1_HUMAN
NCBI Protein Information
transferrin receptor protein 1; transferrin receptor (p90, CD71)

UniProt Comments for TFRC

TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.

Protein type: Receptor, misc.; Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: extracellular space; cell surface; intracellular membrane-bound organelle; integral to plasma membrane; cytoplasmic membrane-bound vesicle; extracellular region; coated pit; recycling endosome; membrane; perinuclear region of cytoplasm; plasma membrane; melanosome; endosome; vesicle; external side of plasma membrane

Molecular Function: identical protein binding; protein binding; transferrin receptor activity; double-stranded RNA binding

Biological Process: receptor-mediated endocytosis; viral reproduction; cellular iron ion homeostasis; transferrin transport; positive regulation of bone resorption; osteoclast differentiation; regulation of cell growth; transmembrane transport; regulation of cell proliferation
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Research Articles on TFRC

1. a critical review the available literature to assess the diagnostic efficacy of sTfR in complicated anemia--{REVIEW}

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TFRC antibody

 Reference Product  PubMed Publications
 HFE antibody  >21 publications with TFRC and HFE
 MYC antibody  >14 publications with TFRC and MYC
 B2M antibody  >12 publications with TFRC and B2M
 EPO antibody  >4 publications with TFRC and EPO
 FTH1 antibody  >3 publications with TFRC and FTH1
 STEAP3 antibody  >1 publications with TFRC and STEAP3

Pathways associated with anti-TFRC antibody

 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Iron Metabolism In Placenta Pathway antibodies  Iron Metabolism In Placenta Pathway Diagram

Diseases associated with anti-TFRC antibody

 Disease Name  Pubmed Publications
 Iron Metabolism Disorders Antibodies  >29 publications with TFRC and Iron Metabolism Disorders
 Anemia Antibodies  >21 publications with TFRC and Anemia
 Disease Models, Animal Antibodies  >15 publications with TFRC and Disease Models, Animal
 Anemia, Iron-Deficiency Antibodies  >11 publications with TFRC and Anemia, Iron-Deficiency
 Inflammation Antibodies  >9 publications with TFRC and Inflammation
 Liver Diseases Antibodies  >8 publications with TFRC and Liver Diseases
 Lung Neoplasms Antibodies  >8 publications with TFRC and Lung Neoplasms
 Breast Neoplasms Antibodies  >6 publications with TFRC and Breast Neoplasms
 Kidney Diseases Antibodies  >6 publications with TFRC and Kidney Diseases
 Colorectal Neoplasms Antibodies  >5 publications with TFRC and Colorectal Neoplasms

Organs/Tissues associated with anti-TFRC antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >45 publications with TFRC and Blood
 Liver Antibodies  >28 publications with TFRC and Liver
 Brain Antibodies  >25 publications with TFRC and Brain
 Lung Antibodies  >14 publications with TFRC and Lung
 Intestine Antibodies  >13 publications with TFRC and Intestine
 Bone Antibodies  >12 publications with TFRC and Bone
 Kidney Antibodies  >10 publications with TFRC and Kidney
 Skin Antibodies  >8 publications with TFRC and Skin
 Embryonic Tissue Antibodies  >6 publications with TFRC and Embryonic Tissue
 Heart Antibodies  >6 publications with TFRC and Heart
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