Homeobox Protein Hox-A10 (HOXA10) Antibody – Rabbit Polyclonal

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 (HOXA9) gene. [provided by RefSeq, Mar 2011]

HOXA10: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'. Belongs to the Abd-B homeobox family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 7p15.2

Cellular Component: transcription factor complex; cytoplasm; nucleus

Molecular Function: protein binding; histone deacetylase binding

Biological Process: anterior/posterior pattern formation; transcription, DNA-dependent; multicellular organismal development; single fertilization; male gonad development; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis; uterus development; skeletal development; proximal/distal pattern formation; embryonic limb morphogenesis