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Multidrug Resistance-Associated Protein 4 (ABCC4) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS177513

Description: Rabbit IgG polyclonal antibody for Multidrug resistance-associated protein 4(ABCC4) detection. Tested with WB, IHC-P in Human;Mouse;Rat.Background: ABCC4(Atp-binding cassette, subfamily c, member 4) also known as MRP4 or MOATB, is a protein that… More details

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Product Overview

Online Datasheet in PDF
Product Name
Multidrug resistance-associated protein 4 (ABCC4), Polyclonal Antibody
Full Product Name
Anti-MRP4 Antibody
Product Gene Name
anti-ABCC4 antibody
Product Synonym Names
ABCC 4 antibody; ABCC4 antibody; ATP binding cassette sub family C (CFTR/MRP) member 4 antibody; ATP binding cassette sub family C member 4 antibody; ATP-binding cassette sub-family C member 4 antibody; bA464I2.1 (ATP binding cassette, sub-family C (CFTR/MRP) member 4) antibody; bA464I2.1 antibody; Canalicular multispecific organic anion transporter ABC superfamily antibody; canalicular multispecific organic anion transporter antibodyEST170205 antibody; MOAT B antibody; MOAT-B antibody; MOATB antibody; MRP 4 antibody; MRP/cMOAT related ABC transporter antibody; MRP/cMOAT-related ABC transporter antibody; MRP4_HUMAN antibody; Multi specific organic anion transporter B antibody; Multi-specific organic anion transporter B antibody; Multidrug resistance associated protein 4 antibody; Multidrug resistance-associated protein 4 antibody; OTTHUMP00000018560 antibody; ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat. No cross reactivity with other proteins.
Form/Format
Lyophilized
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen affinity purified.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
96,841 Da
OMIM
605250
3D Structure
ModBase 3D Structure for O15439
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Immunogen
E.coli-derived human MRP4 recombinant protein (Position: M1-P370).
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-ABCC4 antibody
Western Blot (WB), Immunohistochemistry (IHC-P)
Application Notes for anti-ABCC4 antibody
Western Blot: Concentration: 0.1-0.5mug/ml; Tested Species: Human
Immunohistochemistry (Paraffin-embedded Section): Concentration: 0.5-1mug/ml; Tested Species: Human, Mouse, Rat

Testing Data of anti-ABCC4 antibody

Anti-MRP4 Picoband antibody, MBS177513-1.jpg
All lanes: Anti MRP4 (MBS177513) at 0.5ug/ml
WB: Recombinant Human MRP4 Protein 0.5ng
Predicted bind size: 47KD
Observed bind size: 47KD
Rabbit Anti-ABCC4 Polyclonal Antibody – Cat# MBS177513

Immunohistochemistry (IHC) of anti-ABCC4 antibody

Anti-MRP4 Picoband antibody, MBS177513-2.JPG
IHC(P): Rat Intestine Tissue
Rabbit Anti-ABCC4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS177513

Immunohistochemistry (IHC) of anti-ABCC4 antibody

Anti-MRP4 Picoband antibody, MBS177513-3.JPG
IHC(P): Human Intestinal Cancer Tissue
Rabbit Anti-ABCC4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS177513

Immunohistochemistry (IHC) of anti-ABCC4 antibody

Anti-MRP4 Picoband antibody, MBS177513-4.JPG
IHC(P): Mouse Intestine Tissue
Rabbit Anti-ABCC4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS177513

Other Notes

Small volumes of anti-ABCC4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ABCC4 purchase

MBS177513 is an antibody targeting ABCC4. Also known as Anti-MRP4 Antibody. Reactive in Human, Mouse, Rat. No cross reactivity with other proteins.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ABCC4. It may not necessarily be applicable to this product.

NCBI GI #
157502203
NCBI GeneID
10257
NCBI Accession #
NP_001098985.1
UniProt Primary Accession #
O15439
UniProt Secondary Accession #
Q8IVZ4; Q8IZN6; Q8NEW8; Q9Y6J2; A9Z1Z7
UniProt Related Accession #
O15439
GenBank Nucleotide #
NM_001105515.2
NCBI Official Full Name
multidrug resistance-associated protein 4 isoform 2
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
NCBI Official Symbol
ABCC4
NCBI Official Synonym Symbols
MRP4; MOATB; MOAT-B
UniProt Protein Name
Multidrug resistance-associated protein 4
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 4; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; MOAT-B
Protein Family
ABC transporter C family
UniProt Gene Name
ABCC4
UniProt Synonym Gene Names
MRP4; MOAT-B
UniProt Entry Name
MRP4_HUMAN
NCBI Protein Information
multidrug resistance-associated protein 4; MRP/cMOAT-related ABC transporter; multi-specific organic anion transporter B; bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4); canalicular multispecific organic anion transporter (ABC superfamily)

NCBI Summary for ABCC4

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
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UniProt Comments for ABCC4

ABCC4: a widely-expressed multi-pass membrane protein. An organic anion pump involved in cellular detoxification. Widely expressed, with particularly high levels in prostate, but is barely detectable in liver.

Protein type: Transporter, ABC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q32

Cellular Component: membrane; basolateral plasma membrane; integral to membrane; plasma membrane; platelet dense granule membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; ATP binding

Biological Process: response to drug; platelet activation; platelet degranulation; positive regulation of smooth muscle cell proliferation; blood coagulation; response to organic nitrogen; response to organic cyclic substance; transmembrane transport
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Research Articles on ABCC4

1. study suggests that ABCC4 serves as a novel predictive biomarker that is responsible for the radioresistance and predicts a poor prognosis for locally advanced rectal carcinoma after neoadjuvant radiotherapy

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ABCC4 antibody

 Reference Product  PubMed Publications
 SLC22A8 antibody  >9 publications with ABCC4 and SLC22A8
 SLC22A6 antibody  >8 publications with ABCC4 and SLC22A6
 SLCO1B3 antibody  >7 publications with ABCC4 and SLCO1B3
 SLCO1B1 antibody  >7 publications with ABCC4 and SLCO1B1
 SNX27 antibody  >1 publications with ABCC4 and SNX27

Pathways associated with anti-ABCC4 antibody

 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Drug Induction Of Bile Acid Pathway antibodies  Drug Induction Of Bile Acid Pathway Diagram
 Fluoropyrimidine Activity Pathway antibodies  Fluoropyrimidine Activity Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram

Diseases associated with anti-ABCC4 antibody

 Disease Name  Pubmed Publications
 Cholestasis Antibodies  >21 publications with ABCC4 and Cholestasis
 Inflammation Antibodies  >18 publications with ABCC4 and Inflammation
 Liver Diseases Antibodies  >18 publications with ABCC4 and Liver Diseases
 Adenocarcinoma Antibodies  >13 publications with ABCC4 and Adenocarcinoma
 Disease Models, Animal Antibodies  >13 publications with ABCC4 and Disease Models, Animal
 Necrosis Antibodies  >11 publications with ABCC4 and Necrosis
 Fibrosis Antibodies  >11 publications with ABCC4 and Fibrosis
 Brain Diseases Antibodies  >10 publications with ABCC4 and Brain Diseases
 Colorectal Neoplasms Antibodies  >10 publications with ABCC4 and Colorectal Neoplasms
 Neoplasms, Experimental Antibodies  >9 publications with ABCC4 and Neoplasms, Experimental

Organs/Tissues associated with anti-ABCC4 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >111 publications with ABCC4 and Blood
 Liver Antibodies  >78 publications with ABCC4 and Liver
 Kidney Antibodies  >74 publications with ABCC4 and Kidney
 Brain Antibodies  >47 publications with ABCC4 and Brain
 Vascular Antibodies  >21 publications with ABCC4 and Vascular
 Lung Antibodies  >20 publications with ABCC4 and Lung
 Intestine Antibodies  >19 publications with ABCC4 and Intestine
 Muscle Antibodies  >13 publications with ABCC4 and Muscle
 Prostate Antibodies  >9 publications with ABCC4 and Prostate
 Bone Antibodies  >8 publications with ABCC4 and Bone
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