Human IL-37/IL1F7 PicoKine ELISA Kit standard curve

Interleukin-37 (IL37) ELISA Kit for Human

Name: Human IL37 ELISA Kit; Interleukin-37; MyBioSource
Brand: MyBioSource
SKU: MBS177547
Price: 585 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS177547

Description: Sandwich ELISA kit of Quantitative Detection for Human IL-37/IL1F7Background: Interleukin 37(IL-37) also named IL1F7, is a protein that in humans is encoded by the IL1F7 gene. The protein encoded by this gene is a member of the interleukin 1… More details

$585 / 96-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Interleukin-37 (IL37), ELISA Kit

Full Product Name

Human IL-37/IL1F7 PicoKine ELISA Kit

Product Gene Name

IL37 elisa kit

Product Synonym Names

FIL1; FIL1 zeta; FIL1(ZETA); FIL1Z; IL 1 zeta; IL 1F7; IL 1F7b (IL 1H4, IL 1H, IL 1RP1); IL 1H4; IL 1RP1; IL 1X; IL 1X protein; IL-1 zeta; IL-1F7; IL-1H; IL-1H4; IL-1RP1; IL-1X; IL-37; IL1F7 (canonical product IL 1F7b); IL1F7; IL1F7_HUMAN; IL1H4; IL1RP1; Interleukin 1 family member 7; interleukin 1 family, member 7 (zeta); Interleukin 1 homolog 4; Interleukin 1 related protein; Interleukin 1 superfamily z; Interleukin 1 zeta; Interleukin 37; Interleukin-1 family member 7; Interleukin-1 homolog 4; Interleukin-1 zeta; Interleukin-1-related protein; Interleukin-23; interleukin 37

Species Reactivity

Human. There is no detectable cross-reactivity with other relevant proteins.

Assay Type

Sandwich

Samples

Cell culture supernates, serum and plasma (heparin, EDTA)

Sensitivity

<10pg/ml

Preparation and Storage

Store at 4 degree C for 6 months, at -20 degree C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)

Molecular Weight

17,459 Da

OMIM

605510

3D Structure

ModBase 3D Structure for Q9NZH6

Production Time

Due to severe delay and raw materials shortage, production time may takes between 5-8 weeks.

Immunogen

E.coli, V46-D218

Intra-Assay Precision

Sample 1: n=16; Mean(pg/ml): 178; Standard deviation: 7.3; CV(%): 4.1 Sample 2: n=16; Mean(pg/ml): 304; Standard deviation: 11.86; CV(%): 3.9 Sample 3: n=16; Mean(pg/ml): 569; Standard deviation: 30.2; CV(%): 5.3

Inter-Assay Precision

Sample 1: n=24; Mean(pg/ml): 216; Standard deviation: 12.3; CV(%): 5.7 Sample 2: n=24; Mean(pg/ml): 365; Standard deviation: 15.33; CV(%): 4.2 Sample 3: n=24; Mean(pg/ml): 610; Standard deviation: 39.04; CV(%): 6.4

Assay Range

15.6pg/ml-1000pg/ml

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of IL37 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL37 purchase

MBS177547 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Interleukin-37 (IL37) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing IL37. The ELISA analytical biochemical technique of the MBS177547 kit is based on IL37 antibody-IL37 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IL37 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IL37. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for IL37. It may not necessarily be applicable to this product.

NCBI GI #

20127524

NCBI GeneID

27178

NCBI Accession #

NP_055254.2

UniProt Primary Accession #

Q9NZH6

UniProt Secondary Accession #

Q56AP9; Q8TD04; Q8TD05; Q9HBF2; Q9HBF3; Q9UHA6; B5BU97

UniProt Related Accession #

Q9NZH6

GenBank Nucleotide #

NM_014439.3

NCBI Official Full Name

interleukin-37 isoform 1

NCBI Official Synonym Full Names

interleukin 37

NCBI Official Symbol

IL37

NCBI Official Synonym Symbols

FIL1; FIL1Z; IL-1H; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1; FIL1(ZETA)

UniProt Protein Name

Interleukin-37

UniProt Synonym Protein Names

FIL1 zeta; IL-1X; Interleukin-1 family member 7; IL-1F7; Interleukin-1 homolog 4; IL-1H; IL-1H4; Interleukin-1 zeta; IL-1 zeta; Interleukin-1-related protein; IL-1RP1; Interleukin-23; IL-37

Protein Family

Interleukin

UniProt Gene Name

IL37

UniProt Synonym Gene Names

FIL1Z; IL1F7; IL1H4; IL1RP1; IL-1F7; IL-1H; IL-1H4; IL-1 zeta; IL-1RP1; IL-37

UniProt Entry Name

IL37_HUMAN

NCBI Protein Information

interleukin-37; FIL1 zeta; IL-1 zeta; IL-1X protein; interleukin-23; interleukin 1, zeta; interleukin-1 homolog 4; interleukin-1 superfamily z; interleukin 1 family member 7; interleukin-1-related protein; IL-1F7b (IL-1H4, IL-1H, IL-1RP1); IL1F7 (canonical product IL-1F7b)

NCBI Summary for IL37

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

UniProt Comments for IL37

IL37: Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. Belongs to the IL-1 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 2q12-q14.1

Cellular Component: nucleoplasm; extracellular space; cytoplasm; extracellular region; nucleolus; cytosol; nucleus

Molecular Function: interleukin-1 receptor binding; cytokine activity

Biological Process: cytokine and chemokine mediated signaling pathway; immune response; inflammatory response

Research Articles on IL37

1. show here that IL1A, IL1B and IL1F7 regulatory regions come in close proximity in LPS stimulated cells but not in resting human monocytes

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL37 elisa kit

Reference Product	PubMed Publications
SMAD3 elisa kit	>3 publications with IL37 and SMAD3
CASP1 elisa kit	>2 publications with IL37 and CASP1

Diseases associated with IL37 elisa kit

Disease Name	Pubmed Publications
Inflammation Antibodies	>17 publications with IL37 and Inflammation
Necrosis Antibodies	>5 publications with IL37 and Necrosis
Disease Models, Animal Antibodies	>4 publications with IL37 and Disease Models, Animal
Liver Diseases Antibodies	>3 publications with IL37 and Liver Diseases
Death Antibodies	>2 publications with IL37 and Death
Heart Diseases Antibodies	>2 publications with IL37 and Heart Diseases
Weight Loss Antibodies	>1 publications with IL37 and Weight Loss
Drug-Induced Liver Injury Antibodies	>1 publications with IL37 and Drug-Induced Liver Injury

Organs/Tissues associated with IL37 elisa kit

Organ/Tissue Name	Pubmed Publications
Intestine Antibodies	>1 publications with IL37 and Intestine