Anti-MIP Polyclonal Antibody – Cat# MBS177668

Anti- Aquaporin 0 Picoband antibody, MBS177668, Western blotting
All lanes: Anti Aquaporin 0 (MBS177668) at 0.5ug/ml
WB: Rat Eye Ball Tissue Lysate at 50ug
Predicted bind size: 28KD
Observed bind size: 28KD

Aquaporin 0 (MIP) Antibody – Polyclonal

Name: MIP Antibody; Polyclonal; Rat/Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS177668
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS177668

Description: Rabbit IgG polyclonal antibody for Lens fiber major intrinsic protein(MIP) detection. Tested with WB in Human;Rat.Background: Lens fiber major intrinsic protein, also called MIP26 or MP26, is a protein that in humans is encoded by the MIP gene.… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Aquaporin 0 (MIP), Polyclonal Antibody

Full Product Name

Anti-Aquaporin 0 Antibody

Product Gene Name

anti-MIP antibody

Product Synonym Names

Lens fiber major intrinsic protein; AQP 0; AQP0; Aquaporin; Aquaporin0; Lens fiber major intrinsic protein; LIM 1; LIM1; Major intrinsic protein 26kD; Major intrinsic protein of lens fiber; MIP 26; MIP; MIP26; MP 26; MP26; PALM; major intrinsic protein of lens fiber

Clonality

Polyclonal

Species Reactivity

Rat
Predicted to work with: Human

Form/Format

Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purity/Purification

Immunogen Affinity Purified

Preparation and Storage

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Molecular Weight

28,122 Da

OMIM

154050

3D Structure

ModBase 3D Structure for P30301

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Aquaporin 0 (232-263aa ERLSVLKGAKPDVSNGQPEVTGEPVELNTQAL), different from the related mouse and rat sequences by six amino acids.

Ig Type

Rabbit IgG

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-MIP antibody

Western Blot (WB)

Application Notes for anti-MIP antibody

Western Blot Concentration: 0.1-0.5ug/ml

Product References and Citations for anti-MIP antibody

1. Berry, V., Francis, P., Kaushal, S., Moore, A., Bhattacharya, S. Missense mutations in MIP underlie autosomal dominant 'polymorphic' and lamellar cataracts linked to 12q. Nature Genet. 25: 15-17, 2000. 2. Francis, P., Chung, J.-J., Yasui, M., Berry, V., Moore, A., Wyatt, M. K., Wistow, G., Bhattacharya, S. S., Agre, P. Functional impairment of lens aquaporin in two families with dominantly inherited cataracts. Hum. Molec. Genet. 9: 2329-2334, 2000. 3. Pisano MM, Chepelinsky AB (Mar 1992). "Genomic cloning, complete nucleotide sequence, and structure of the human gene encoding the major intrinsic protein (MIP) of the lens". Genomics 11 (4): 981-90.

Other Notes

Small volumes of anti-MIP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MIP purchase

MBS177668 is an antibody targeting MIP. Also known as Anti-Aquaporin 0 Antibody. Reactive in Rat
Predicted to work with: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for MIP. It may not necessarily be applicable to this product.

NCBI GI #

6912506

NCBI GeneID

4284

NCBI Accession #

NP_036196.1

UniProt Primary Accession #

P30301

UniProt Secondary Accession #

Q17R41

UniProt Related Accession #

P30301

GenBank Nucleotide #

NM_012064.3

NCBI Official Full Name

lens fiber major intrinsic protein

NCBI Official Synonym Full Names

major intrinsic protein of lens fiber

NCBI Official Symbol

MIP

NCBI Official Synonym Symbols

AQP0; LIM1; MP26; MIP26; CTRCT15

UniProt Protein Name

Lens fiber major intrinsic protein

UniProt Synonym Protein Names

Aquaporin-0; MIP26; MP26

Protein Family

Allatostatins

UniProt Gene Name

MIP

UniProt Synonym Gene Names

AQP0; MP26

UniProt Entry Name

MIP_HUMAN

NCBI Protein Information

lens fiber major intrinsic protein

NCBI Summary for MIP

Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13. [provided by RefSeq, Jul 2008]

UniProt Comments for MIP

AQP0: major intrinsic protein of lens fiber. A member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. May be responsible for regulating the osmolarity of the lens. Defects in MIP are a cause of autosomal recessive congenital cataract.

Protein type: Membrane protein, integral; Transporter, aquaporin family; Channel, misc.; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: apical plasma membrane; endoplasmic reticulum; gap junction; integral to plasma membrane; intracellular canaliculus; plasma membrane

Molecular Function: calmodulin binding; gap junction channel activity; glycerol channel activity; structural constituent of eye lens; transporter activity; water channel activity

Biological Process: canalicular bile acid transport; cellular water homeostasis; glycerol transport; lens development in camera-type eye; positive regulation of cell adhesion; protein homotetramerization; response to stimulus; visual perception; water transport

Disease: Cataract 15, Multiple Types

Research Articles on MIP

1. the p.D150H mutation is a novel disease-causing mutation in MIP, which leads to congenital progressive cortical punctate cataract by impairing the trafficking mechanism of AQP0.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MIP antibody

Reference Product	PubMed Publications
CRYGC antibody	>9 publications with MIP and CRYGC
CRYAA antibody	>9 publications with MIP and CRYAA
RAN antibody	>8 publications with MIP and RAN
GJA3 antibody	>7 publications with MIP and GJA3

Pathways associated with anti-MIP antibody

Products by Pathway	Pathway Diagram
Aquaporin-mediated Transport Pathway antibodies	Aquaporin-mediated Transport Pathway Diagram
Passive Transport By Aquaporins Pathway antibodies	Passive Transport By Aquaporins Pathway Diagram
Transmembrane Transport Of Small Molecules Pathway antibodies	Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-MIP antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>2630 publications with MIP and Inflammation
Necrosis Antibodies	>1752 publications with MIP and Necrosis
Lung Diseases Antibodies	>1230 publications with MIP and Lung Diseases
Cardiovascular Diseases Antibodies	>914 publications with MIP and Cardiovascular Diseases
Death Antibodies	>323 publications with MIP and Death
Liver Diseases Antibodies	>304 publications with MIP and Liver Diseases
Kidney Diseases Antibodies	>210 publications with MIP and Kidney Diseases
Lung Neoplasms Antibodies	>195 publications with MIP and Lung Neoplasms
Edema Antibodies	>174 publications with MIP and Edema
Hemorrhage Antibodies	>123 publications with MIP and Hemorrhage

Organs/Tissues associated with anti-MIP antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>752 publications with MIP and Brain
Eye Antibodies	>404 publications with MIP and Eye
Kidney Antibodies	>360 publications with MIP and Kidney
Mammary Gland Antibodies	>8 publications with MIP and Mammary Gland
Adrenal Gland Antibodies	>7 publications with MIP and Adrenal Gland