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Annexin A3 (ANXA3) Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS177679

Description: Rabbit IgG polyclonal antibody for Annexin A3(ANXA3) detection. Tested with WB, IHC-P, IHC-F in Human;Mouse;Rat.Background: Annexin A3 is a protein that in humans is encoded by the Annexin A3 gene. The Annexin A3 gene contains 13 exons and spans… More details

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Product Overview

Online Datasheet in PDF
Product Name
Annexin A3 (ANXA3), Polyclonal Antibody
Full Product Name
Anti-Annexin A3 Antibody
Product Gene Name
anti-ANXA3 antibody
Product Synonym Names
Annexin A3; 2-cyclic phosphate 2-phosphohydrolase; 35-alpha calcimedin; Annexin A3; Annexin III; Annexin-3; ANX3; ANXA 3; Anxa3; ANXA3_HUMAN; Inositol 1 2 cyclic phosphate 2 phosphohydrolase; Inositol 1; Lipocortin III; OTTHUMP00000160701; OTTHUMP00000219237; OTTHUMP00000219238; PAP III; PAP-III; Placental anticoagulant protein III; annexin A3
Clonality
Polyclonal
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen Affinity Purified
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
36,375 Da
OMIM
106490
3D Structure
ModBase 3D Structure for P12429
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human Annexin A3 (153-184aa RKALLTLADGRRDESLKVDEHLAKQDAQILYK), different from the related mouse sequence by one amino acid, and from the related rat sequence by three amino acids.
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-ANXA3 antibody
Western Blot (WB), Immunohistochemistry (IHC) Formalin/Paraffin
Application Notes for anti-ANXA3 antibody
Western Blot Concentration: 0.1-0.5ug/ml
Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml
Immunohistochemistry (IHC) Formalin Concentration: 0.5-1ug/ml

Western Blot (WB) of anti-ANXA3 antibody

Anti- Annexin A3 Picoband antibody, MBS177679, Western blotting
All lanes: Anti Annexin A3 (MBS177679) at 0.5ug/ml
Lane 1: Rat Spleen Tissue Lysate at 50ug
Lane 2: Rat Stomach Tissue Lysate at 50ug
Lane 3: HELA Whole Cell Lysate at 40ug
Lane 4: 22RV1 Whole Cell Lysate at 40ug
Lane 5: A549 Whole Cell Lysate at 40ug
Lane 6: MCF-7 Whole Cell Lysate at 40ug
Lane 7: SW620 Whole Cell Lysate at 40ug
Predicted bind size: 36KD
Observed bind size: 36KD
Anti-ANXA3 Polyclonal Antibody – Cat# MBS177679

Immunohistochemistry (IHC) of anti-ANXA3 antibody

Anti- Annexin A3 Picoband antibody, MBS177679, IHC(P)
IHC(P): Mouse Cardiac Muscle Tissue
Anti-ANXA3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS177679

Immunohistochemistry (IHC) of anti-ANXA3 antibody

Anti- Annexin A3 Picoband antibody, MBS177679, IHC(P)
IHC(P): Rat Cardiac Muscle Tissue
Anti-ANXA3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS177679

Immunohistochemistry (IHC) of anti-ANXA3 antibody

Anti- Annexin A3 Picoband antibody, MBS177679, IHC(P)
IHC(P): Human Mammary Cancer Tissue
Anti-ANXA3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS177679

Immunohistochemistry (IHC) of anti-ANXA3 antibody

Anti- Annexin A3 Picoband antibody, MBS177679, IHC(F)
IHC(F): Mouse Cardiac Muscle Tissue
Anti-ANXA3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS177679

Immunohistochemistry (IHC) of anti-ANXA3 antibody

Anti- Annexin A3 Picoband antibody, MBS177679, IHC(F)
IHC(F): Rat Cardiac Muscle Tissue
Anti-ANXA3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS177679

Immunohistochemistry (IHC) of anti-ANXA3 antibody

Anti- Annexin A3 Picoband antibody, MBS177679, IHC(F)
IHC(F): Human Placenta Tissue
Anti-ANXA3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS177679

Product References and Citations for anti-ANXA3 antibody

1. Bianchi C, et al. Primary cell cultures from human renal cortex and renal-cell carcinoma evidence a differential expression of two spliced isoforms of Annexin A3. Am J Pathol, 2010 Apr. 2. Jung EJ, et al. Decreased annexin A3 expression correlates with tumor progression in papillary thyroid cancer. Proteomics Clin Appl, 2010 May. 3. Yan X, et al. Increased expression of annexin A3 is a mechanism of platinum resistance in ovarian cancer. Cancer Res, 2010 Feb 15.

Other Notes

Small volumes of anti-ANXA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ANXA3 purchase

MBS177679 is an antibody targeting ANXA3. Also known as Anti-Annexin A3 Antibody. Reactive in Human, Mouse, Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for ANXA3. It may not necessarily be applicable to this product.

NCBI GI #
4826643
NCBI GeneID
306
NCBI Accession #
NP_005130.1
UniProt Primary Accession #
P12429
UniProt Secondary Accession #
Q6LET2; B2R9W6
UniProt Related Accession #
P12429
GenBank Nucleotide #
NM_005139.2
NCBI Official Full Name
annexin A3
NCBI Official Synonym Full Names
annexin A3
NCBI Official Symbol
ANXA3
NCBI Official Synonym Symbols
ANX3
UniProt Protein Name
Annexin A3
UniProt Synonym Protein Names
35-alpha calcimedin; Annexin III; Annexin-3; Inositol 1,2-cyclic phosphate 2-phosphohydrolase; Lipocortin III; Placental anticoagulant protein III; PAP-III
Protein Family
Annexin
UniProt Gene Name
ANXA3
UniProt Synonym Gene Names
ANX3; PAP-III
UniProt Entry Name
ANXA3_HUMAN
NCBI Protein Information
annexin A3

NCBI Summary for ANXA3

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008]
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UniProt Comments for ANXA3

ANXA3: a calcium/phospholipid-binding protein and inhibitor of phospholipase A2, Possesses anti-coagulant properties. Cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 4q21.21

Cellular Component: axon; cell soma; cytoplasm; dendrite; membrane; phagocytic vesicle membrane; plasma membrane; specific granule

Molecular Function: calcium ion binding; calcium-dependent phospholipid binding; calcium-dependent protein binding; phospholipase A2 inhibitor activity

Biological Process: defense response to bacterium; hippocampus development; negative regulation of catalytic activity; neutrophil degranulation; organ regeneration; phagocytosis; positive regulation of angiogenesis; positive regulation of DNA metabolic process; positive regulation of transcription factor activity; response to glucocorticoid stimulus
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Research Articles on ANXA3

1. Findings reveal that ANXA3 might play an important role in hepatocellular carcinoma progression and chemoresistance.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ANXA3 antibody

 Reference Product  PubMed Publications
 ANXA4 antibody  >1 publications with ANXA3 and ANXA4

Pathways associated with anti-ANXA3 antibody

 Products by Pathway  Pathway Diagram
 Prostaglandin Synthesis And Regulation Pathway antibodies  Prostaglandin Synthesis And Regulation Pathway Diagram

Diseases associated with anti-ANXA3 antibody

 Disease Name  Pubmed Publications
 Prostatic Neoplasms Antibodies  >10 publications with ANXA3 and Prostatic Neoplasms
 Liver Diseases Antibodies  >6 publications with ANXA3 and Liver Diseases
 Inflammation Antibodies  >5 publications with ANXA3 and Inflammation
 Liver Neoplasms Antibodies  >4 publications with ANXA3 and Liver Neoplasms
 Neoplasm Metastasis Antibodies  >4 publications with ANXA3 and Neoplasm Metastasis
 Lung Neoplasms Antibodies  >4 publications with ANXA3 and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >4 publications with ANXA3 and Carcinoma, Hepatocellular
 Arthritis, Rheumatoid Antibodies  >3 publications with ANXA3 and Arthritis, Rheumatoid
 Pancreatic Neoplasms Antibodies  >3 publications with ANXA3 and Pancreatic Neoplasms
 Disease Models, Animal Antibodies  >3 publications with ANXA3 and Disease Models, Animal

Organs/Tissues associated with anti-ANXA3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >18 publications with ANXA3 and Blood
 Liver Antibodies  >11 publications with ANXA3 and Liver
 Prostate Antibodies  >10 publications with ANXA3 and Prostate
 Brain Antibodies  >5 publications with ANXA3 and Brain
 Kidney Antibodies  >4 publications with ANXA3 and Kidney
 Vascular Antibodies  >4 publications with ANXA3 and Vascular
 Lung Antibodies  >4 publications with ANXA3 and Lung
 Lymph Node Antibodies  >2 publications with ANXA3 and Lymph Node
 Heart Antibodies  >2 publications with ANXA3 and Heart
 Embryonic Tissue Antibodies  >1 publications with ANXA3 and Embryonic Tissue
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