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Lumican (LUM) Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS177712

Description: Rabbit IgG polyclonal antibody for Lumican(LUM) detection. Tested with WB, IHC-P, ELISA in Mouse.Background: Lumican, also known as LUM, is an extracellular matrix protein that, in humans, is encoded by the LUM gene on chromosome 12. Lumican is a… More details

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Product Documentation
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Lumican, Polyclonal Antibody
Full Product Name
Anti-Lumican Antibody
Product Gene Name
anti-Lum antibody
Product Synonym Names
Lumican; Keratan sulfate proteoglycan lumican; KSPG lumican; LDC; LUM; LUM_HUMAN; Lumican; Lumican precursor; SLRR2D; lumican
Clonality
Polyclonal
Species Reactivity
Mouse
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen Affinity Purified
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
38,265 Da
3D Structure
ModBase 3D Structure for P51885
Immunogen
E Coli-derived mouse Lumican recombinant protein (Position: I68-N338). Mouse Lumican shares 88.9% and 98.2% amino acid (aa) sequence identity with human and rat Lumican, respectively.
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-Lum antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, ELISA (EIA)
Application Notes for anti-Lum antibody
ELISA Concentration: 0.1-0.5ug/ml
Western Blot Concentration: 0.1-0.5ug/ml
Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml

Western Blot (WB) of anti-Lum antibody

Anti- Lumican Picoband antibody, MBS177712, Western blotting
All lanes: Anti Lumican (MBS177712) at 0.5ug/ml
Lane 1: Mouse Testis Tissue Lysate at 50ug
Lane 2: Mouse Thymus Tissue Lysate at 50ug
Lane 3: NIH3T3 Whole Cell Lysate at 40ug
Predicted bind size: 38KD
Observed bind size: 60KD
Anti-LUM Polyclonal Antibody – Cat# MBS177712

Immunohistochemistry (IHC) of anti-Lum antibody

Anti- Lumican Picoband antibody, MBS177712, IHC(P)
IHC(P): Mouse Brain Tissue
Anti-LUM Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS177712

Product References and Citations for anti-Lum antibody

1. "Entrez Gene: LUM lumican". 2. Chakravarti S, Stallings RL, SundarRaj N, Cornuet PK, Hassell JR (Jun 1995). "Primary structure of human lumican (keratan sulfate proteoglycan) and localization of the gene (LUM) to chromosome 12q21.3-q22". Genomics27 (3): 481-8. 3. Chakravarti S (2002). "Functions of lumican and fibromodulin: lessons from knockout mice". Glycoconjugate Journal 19 (4-5): 287-93.

Other Notes

Small volumes of anti-Lum antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Lum purchase

MBS177712 is an antibody targeting Lum. Also known as Anti-Lumican Antibody. Reactive in Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Lum. It may not necessarily be applicable to this product.

NCBI GI #
160333372
NCBI GeneID
17022
NCBI Accession #
NP_032550.2
UniProt Primary Accession #
P51885
UniProt Secondary Accession #
Q3TP25; Q99JZ3; Q9CXK0
UniProt Related Accession #
P51885
GenBank Nucleotide #
NM_008524.2
NCBI Official Full Name
lumican
NCBI Official Synonym Full Names
lumican
NCBI Official Symbol
Lum
NCBI Official Synonym Symbols
Ldc; SLRR2D
UniProt Protein Name
Lumican
UniProt Synonym Protein Names
Keratan sulfate proteoglycan lumican; KSPG lumican
Protein Family
Lumican
UniProt Gene Name
Lum
UniProt Synonym Gene Names
Lcn; Ldc; KSPG lumican
UniProt Entry Name
LUM_MOUSE
NCBI Protein Information
lumican

UniProt Comments for Lum

LUM: a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]

Protein type: Secreted, signal peptide; Secreted

Cellular Component: extracellular matrix; extracellular region; extracellular space; fibrillar collagen; proteinaceous extracellular matrix

Molecular Function: collagen binding

Biological Process: collagen fibril organization; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transforming growth factor-beta1 production; visual perception
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Research Articles on Lum

1. LUM may coordinate multiple factors of collagen assembly in the murine heart.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Lum antibody

 Reference Product  PubMed Publications
 Dcn antibody  >67 publications with Lum and Dcn
 Fmod antibody  >54 publications with Lum and Fmod
 Kera antibody  >30 publications with Lum and Kera
 Prelp antibody  >9 publications with Lum and Prelp
 Ogn antibody  >6 publications with Lum and Ogn

Pathways associated with anti-Lum antibody

 Products by Pathway  Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Keratan Sulfate Biosynthesis Pathway antibodies  Keratan Sulfate Biosynthesis Pathway Diagram
 Keratan Sulfate Degradation Pathway antibodies  Keratan Sulfate Degradation Pathway Diagram
 Keratan Sulfate/keratin Metabolism Pathway antibodies  Keratan Sulfate/keratin Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Carbohydrates Pathway antibodies  Metabolism Of Carbohydrates Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram

Diseases associated with anti-Lum antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >270 publications with Lum and Nervous System Diseases
 Brain Diseases Antibodies  >158 publications with Lum and Brain Diseases
 Carcinoma Antibodies  >114 publications with Lum and Carcinoma
 Inflammation Antibodies  >86 publications with Lum and Inflammation
 Breast Neoplasms Antibodies  >79 publications with Lum and Breast Neoplasms
 Disease Models, Animal Antibodies  >75 publications with Lum and Disease Models, Animal
 Kidney Diseases Antibodies  >65 publications with Lum and Kidney Diseases
 Liver Diseases Antibodies  >57 publications with Lum and Liver Diseases
 Necrosis Antibodies  >54 publications with Lum and Necrosis
 Neoplasms, Experimental Antibodies  >48 publications with Lum and Neoplasms, Experimental

Organs/Tissues associated with anti-Lum antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >174 publications with Lum and Lung
 Bone Antibodies  >172 publications with Lum and Bone
 Brain Antibodies  >143 publications with Lum and Brain
 Kidney Antibodies  >98 publications with Lum and Kidney
 Heart Antibodies  >94 publications with Lum and Heart
 Eye Antibodies  >86 publications with Lum and Eye
 Muscle Antibodies  >85 publications with Lum and Muscle
 Skin Antibodies  >71 publications with Lum and Skin
 Joint Antibodies  >56 publications with Lum and Joint
 Connective Tissue Antibodies  >42 publications with Lum and Connective Tissue
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