Calcineurin A (PPP3CA) Antibody – Polyclonal

PPP3CA: a calmodulin-dependent Ser/Thr phosphatase also known calcineurin A alpha. Involved in a wide range of biologic activities, acting as a Ca(2 )-dependent modifier of phosphorylation status. Dephosphorylates HSPB1. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. .

Protein type: EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 4q24

Cellular Component: calcineurin complex; cytoplasm; cytosol; mitochondrion; nucleoplasm; sarcolemma; Z disc

Molecular Function: calcium ion binding; calmodulin binding; calmodulin-dependent protein phosphatase activity; drug binding; enzyme binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein serine/threonine phosphatase activity

Biological Process: calcineurin-NFAT signaling pathway; calcium ion transport; cardiac muscle hypertrophy; dephosphorylation; G1/S transition of mitotic cell cycle; multicellular organismal response to stress; negative regulation of dendrite morphogenesis; negative regulation of insulin secretion; positive regulation of NFAT protein import into nucleus; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein amino acid dephosphorylation; protein import into nucleus; regulation of excitatory postsynaptic membrane potential; regulation of synaptic transmission; response to amphetamine; response to calcium ion; skeletal muscle fiber development; T cell activation; transition between fast and slow fiber; Wnt receptor signaling pathway, calcium modulating pathway