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PTGER2 Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS177748

Description: Rabbit IgG polyclonal antibody for Prostaglandin E2 receptor EP2 subtype(PTGER2) detection. Tested with WB in Human.Background: Prostaglandin E2 receptor (53kDa), also known as EP2, is aprostaglandin receptor for prostaglandin E2. It is encoded… More details

$210 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PTGER2, Polyclonal Antibody
Full Product Name
Anti-PTGER2 Antibody
Product Gene Name
anti-PTGER2 antibody
Product Synonym Names
Prostaglandin E2 receptor EP2 subtype; EP 2; EP2; Human prostaglandin E2 receptor; PE2R2_HUMAN; PGE receptor EP2 subtype; PGE2 receptor EP2 subtype; Prostaglandin E receptor 2 EP2 subtype; Prostaglandin E receptor 2 subtype EP2 53kDa; Prostaglandin E receptor 2 subtype EP2; Prostaglandin E2 receptor; Prostaglandin E2 receptor EP2 subtype; Prostanoid EP2 receptor; PTGER 2; PTGER2; prostaglandin E receptor 2 (subtype EP2), 53kDa
Clonality
Polyclonal
Species Reactivity
Human
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen Affinity Purified
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
39,761 Da
OMIM
176804
3D Structure
ModBase 3D Structure for P43116
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human PTGER2 (281-308aa TIFAYMNETSSRKEKWDLQALRFLSINS), different from the related mouse sequence by four amino acids, and from the related rat sequence by three amino acids.
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-PTGER2 antibody
Western Blot (WB)
Application Notes for anti-PTGER2 antibody
Western Blot Concentration: 0.1-0.5ug/ml

Western Blot (WB) of anti-PTGER2 antibody

Anti-PTGER2 Picoband antibody, MBS177748, Western blotting
All lanes: Anti PTGER2 (MBS177748) at 0.5ug/ml
Lane 1: Human Placenta Tissue Lysate at 50ug
Lane 2: A549 Whole Cell Lysate at 40ug
Lane 3: HEPG2 Whole Cell Lysate at 40ug
Predicted bind size: 40KD
Observed bind size: 40KD
Anti-PTGER2 Polyclonal Antibody – Cat# MBS177748

Product References and Citations for anti-PTGER2 antibody

1. Smock, S. L., Pan, L. C., Castleberry, T. A., Lu, B., Mather, R. J., Owen, T. A. Cloning, structural characterization, and chromosomal localization of the gene encoding the human prostaglandin E2 receptor EP2 subtype. Gene 237: 393-402, 1999. 2. Sugimoto Y, Nakato T, Kita A et al. (2004). "A cluster of aromatic amino acids in the i2 loop plays a key role for Gs coupling in prostaglandin EP2 and EP3 receptors". J. Biol. Chem. 279 (12): 11016-26.

Other Notes

Small volumes of anti-PTGER2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTGER2 purchase

MBS177748 is an antibody targeting PTGER2. Reactive in Human.

Additional Details

NCBI/Uniprot data below describe general gene information for PTGER2. It may not necessarily be applicable to this product.

NCBI GI #
31881630
NCBI GeneID
5732
NCBI Accession #
NP_000947.2
UniProt Primary Accession #
P43116
UniProt Secondary Accession #
Q52LG8; D3DSC0
UniProt Related Accession #
P43116
GenBank Nucleotide #
NM_000956.3
NCBI Official Full Name
prostaglandin E2 receptor EP2 subtype
NCBI Official Synonym Full Names
prostaglandin E receptor 2
NCBI Official Symbol
PTGER2
NCBI Official Synonym Symbols
EP2
UniProt Protein Name
Prostaglandin E2 receptor EP2 subtype
UniProt Synonym Protein Names
Prostanoid EP2 receptor
Protein Family
Prostaglandin E2 receptor
UniProt Gene Name
PTGER2
UniProt Synonym Gene Names
PGE receptor EP2 subtype; PGE2 receptor EP2 subtype
UniProt Entry Name
PE2R2_HUMAN
NCBI Protein Information
prostaglandin E2 receptor EP2 subtype

NCBI Summary for PTGER2

This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009]

UniProt Comments for PTGER2

PTGER2: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 14q22

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: prostaglandin E receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase activating pathway; regulation of cell proliferation; response to lipopolysaccharide; response to progesterone stimulus

Disease: Asthma, Nasal Polyps, And Aspirin Intolerance
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Research Articles on PTGER2

1. Reduced EP2 receptor expression results in resistance to the antiproliferative effects of EP2 signaling in nasal polyp fibroblasts from subjects with AERD and support a role for EP2 signaling in the aberrant growth of nasal polyp tissue.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PTGER2 antibody

 Reference Product  PubMed Publications
 PTGER4 antibody  >220 publications with PTGER2 and PTGER4
 ADRB2 antibody  >3 publications with PTGER2 and ADRB2
 FSHR antibody  >2 publications with PTGER2 and FSHR
 POMC antibody  >1 publications with PTGER2 and POMC
 CRH antibody  >1 publications with PTGER2 and CRH

Pathways associated with anti-PTGER2 antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Eicosanoid Ligand-binding Receptors Pathway antibodies  Eicosanoid Ligand-binding Receptors Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-PTGER2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >74 publications with PTGER2 and Inflammation
 Necrosis Antibodies  >38 publications with PTGER2 and Necrosis
 Lung Diseases Antibodies  >34 publications with PTGER2 and Lung Diseases
 Disease Models, Animal Antibodies  >27 publications with PTGER2 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >23 publications with PTGER2 and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >13 publications with PTGER2 and Adenocarcinoma
 Lung Neoplasms Antibodies  >12 publications with PTGER2 and Lung Neoplasms
 Kidney Diseases Antibodies  >9 publications with PTGER2 and Kidney Diseases
 Endometriosis Antibodies  >7 publications with PTGER2 and Endometriosis
 Hypertension Antibodies  >6 publications with PTGER2 and Hypertension

Organs/Tissues associated with anti-PTGER2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >112 publications with PTGER2 and Blood
 Lung Antibodies  >48 publications with PTGER2 and Lung
 Uterus Antibodies  >44 publications with PTGER2 and Uterus
 Kidney Antibodies  >32 publications with PTGER2 and Kidney
 Eye Antibodies  >21 publications with PTGER2 and Eye
 Bone Marrow Antibodies  >17 publications with PTGER2 and Bone Marrow
 Liver Antibodies  >10 publications with PTGER2 and Liver
 Connective Tissue Antibodies  >9 publications with PTGER2 and Connective Tissue
 Ascites Antibodies  >2 publications with PTGER2 and Ascites
 Adipose Tissue Antibodies  >1 publications with PTGER2 and Adipose Tissue
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