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Syndecan 4 (SDC4) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS177756

Syndecan 4 is also known as SDC4. The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is amember of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization… More details

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Product Documentation
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Syndecan 4 (SDC4), Polyclonal Antibody
Full Product Name
Anti-Syndecan 4 Antibody
Product Gene Name
anti-SDC4 antibody
Product Synonym Names
Syndecan-4; Amphiglycan; Amphiglycan; MGC22217; OTTHUMP00000031788; ryudocan amphiglycan; Ryudocan; Ryudocan core protein; Ryudocan core protein; SDC 4; SDC4; SDC4_HUMAN; SYND 4; SYND4; syndecan 4; syndecan 4 (amphiglycan, ryudocan); syndecan proteoglycan 4; Syndecan-4; Syndecan4; syndecan 4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen Affinity Purified
Specificity
No cross reactivity with other proteins
Preparation and Storage
Store at -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquoted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
OMIM
600017
3D Structure
ModBase 3D Structure for P31431
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Syndecan 4 (172-198aa MKKKDEGSYDLGKKPIYKKAPTNEFYA), identical to the related mouse and rat sequences.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Relevant Detection System
The lab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG ( MBS176460 ) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit ( MBS176453 ) for IHC(P).
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-SDC4 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Application Notes for anti-SDC4 antibody
WB: Concentration: 0.1-0.5ug/ml; Tested Species: Human, Rat
IHC-P: Concentration: 0.5-1ug/ml; Tested Species: Human, Mouse, Rat
WB: The detection limit for Syndecan 4 is approximately 0.1ng/lane under reducing conditions.

Tested Species: In-house tested species with positive results.
By Heat: Boiling the paraffin section in 10mM citrate, pH 6.0, for 20mins is required for the staining of formalin/paraffin sections.
Other applications have not been tested.
Optimal dilutions should be be determined by end users.

Western Blot (WB) of anti-SDC4 antibody

Anti- Syndecan 4 Picoband antibody, MBS177756, Western blotting
All lanes: Anti Syndecan 4 (MBS177756) at 0.5ug/ml
Lane 1: MCF-7 Whole Cell Lysate at 40ug
Lane 2: SW620 Whole Cell Lysate at 40ug
Lane 3: Rat Lung Tissue Lysate at 50ug
Predicted bind size: 22KD
Observed bind size: 22KD
Rabbit Anti-SDC4 Polyclonal Antibody – Cat# MBS177756

Immunohistochemistry (IHC) of anti-SDC4 antibody

Anti- Syndecan 4 Picoband antibody, MBS177756, IHC(P)
IHC(P): Mouse Intestine Tissue
Rabbit Anti-SDC4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS177756

Immunohistochemistry (IHC) of anti-SDC4 antibody

Anti- Syndecan 4 Picoband antibody, MBS177756, IHC(P)
IHC(P): Rat Intestine Tissue
Rabbit Anti-SDC4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS177756

Immunohistochemistry (IHC) of anti-SDC4 antibody

Anti- Syndecan 4 Picoband antibody, MBS177756, IHC(P)
IHC(P): Human Mammary Cancer Tissue
Rabbit Anti-SDC4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS177756

Product References and Citations for anti-SDC4 antibody

1. "Entrez Gene: SDC4 syndecan 4". 2. Woods A, Couchman JR (May 1998). "Syndecans: synergistic activators of cell adhesion". Trends Cell Biol. 8 (5): 189-92.

Other Notes

Small volumes of anti-SDC4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SDC4 purchase

MBS177756 is an antibody targeting SDC4. Also known as Anti-Syndecan 4 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SDC4. It may not necessarily be applicable to this product.

NCBI GI #
38201675
NCBI GeneID
6385
NCBI Accession #
NP_002990.2
UniProt Primary Accession #
P31431
UniProt Secondary Accession #
O00773; Q16833; Q53FN9; Q6FGN3
UniProt Related Accession #
P31431
GenBank Nucleotide #
NM_002999.3
NCBI Official Full Name
syndecan-4
NCBI Official Synonym Full Names
syndecan 4
NCBI Official Symbol
SDC4
NCBI Official Synonym Symbols
SYND4
UniProt Protein Name
Syndecan-4
UniProt Synonym Protein Names
Amphiglycan; Ryudocan core protein
Protein Family
Syndecan
UniProt Gene Name
SDC4
UniProt Synonym Gene Names
SYND4
UniProt Entry Name
SDC4_HUMAN
NCBI Protein Information
syndecan-4

NCBI Summary for SDC4

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
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UniProt Comments for SDC4

syndecan-4: a heparan sulfate proteoglycan type I membrane protein that belongs to the syndecan proteoglycan family. Expressed as a homodimer. Promotes cell spreading in a beta(1) integrin-dependent fashion through PKC-alpha and Rho.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 20q12

Cellular Component: cell surface; costamere; focal adhesion; Golgi lumen; integral to plasma membrane; lipid raft; lysosomal lumen; plasma membrane

Molecular Function: fibronectin binding; protein binding; protein kinase C binding

Biological Process: cell migration; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; glycosaminoglycan metabolic process; inner ear receptor stereocilium organization and biogenesis; neural tube closure; positive regulation of focal adhesion formation; positive regulation of protein kinase activity; positive regulation of stress fiber formation; retinoid metabolic process; signal transduction; ureteric bud development; wound healing
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Research Articles on SDC4

1. demonstrate that HER2 is captured via a site, comprised of amino acids 210-240, in the extracellular domain of human Sdc1, and EGFR is captured via an extracellular site comprised of amino acids 87-131 in human Sdc4

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SDC4 antibody

 Reference Product  PubMed Publications
 FGF2 antibody  >34 publications with SDC4 and FGF2
 PRKCA antibody  >10 publications with SDC4 and PRKCA
 CXCL12 antibody  >6 publications with SDC4 and CXCL12
 GPC1 antibody  >3 publications with SDC4 and GPC1
 SDCBP antibody  >2 publications with SDC4 and SDCBP
 TNC antibody  >1 publications with SDC4 and TNC
 GIPC1 antibody  >1 publications with SDC4 and GIPC1

Pathways associated with anti-SDC4 antibody

 Products by Pathway  Pathway Diagram
 A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway antibodies  A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Defective B3GALT6 Causes EDSP2 And SEMDJL1 Pathway antibodies  Defective B3GALT6 Causes EDSP2 And SEMDJL1 Pathway Diagram
 Defective B3GAT3 Causes JDSSDHD Pathway antibodies  Defective B3GAT3 Causes JDSSDHD Pathway Diagram
 Defective B4GALT7 Causes EDS, Progeroid Type Pathway antibodies  Defective B4GALT7 Causes EDS, Progeroid Type Pathway Diagram
 Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway antibodies  Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway Diagram
 Defective EXT2 Causes Exostoses 2 Pathway antibodies  Defective EXT2 Causes Exostoses 2 Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram

Diseases associated with anti-SDC4 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >24 publications with SDC4 and Inflammation
 Necrosis Antibodies  >20 publications with SDC4 and Necrosis
 Cardiovascular Diseases Antibodies  >17 publications with SDC4 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >13 publications with SDC4 and Disease Models, Animal
 Fibrosis Antibodies  >11 publications with SDC4 and Fibrosis
 Breast Neoplasms Antibodies  >10 publications with SDC4 and Breast Neoplasms
 Nervous System Diseases Antibodies  >9 publications with SDC4 and Nervous System Diseases
 Liver Diseases Antibodies  >8 publications with SDC4 and Liver Diseases
 Kidney Diseases Antibodies  >8 publications with SDC4 and Kidney Diseases
 Brain Diseases Antibodies  >7 publications with SDC4 and Brain Diseases

Organs/Tissues associated with anti-SDC4 antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >48 publications with SDC4 and Vascular
 Muscle Antibodies  >40 publications with SDC4 and Muscle
 Kidney Antibodies  >22 publications with SDC4 and Kidney
 Bone Antibodies  >21 publications with SDC4 and Bone
 Skin Antibodies  >19 publications with SDC4 and Skin
 Embryonic Tissue Antibodies  >18 publications with SDC4 and Embryonic Tissue
 Lung Antibodies  >18 publications with SDC4 and Lung
 Heart Antibodies  >17 publications with SDC4 and Heart
 Liver Antibodies  >15 publications with SDC4 and Liver
 Brain Antibodies  >13 publications with SDC4 and Brain
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