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Caspase-7 (CASP7) Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS177767

Description: Rabbit IgG polyclonal antibody for Caspase-7(CASP7) detection. Tested with WB, IHC-P in Human;Rat.Background: CASP7, Caspase-7, apoptosis-related cysteine peptidase, is a human protein encoded by the CASP7 gene. CASP7 orthologs have been… More details

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Product Overview

Online Datasheet in PDF
Product Name
Caspase-7 (CASP7), Polyclonal Antibody
Full Product Name
Anti-Caspase-7 Antibody
Product Gene Name
anti-CASP7 antibody
Product Synonym Names
Caspase-7; Apoptosis related cysteine peptidase; Apoptosis Related Cysteine Protease; Apoptosis Related Cysteine Protease; Apoptotic protease Mch-3; Apoptotic Protease MCH3; Apoptotic Protease MCH3; CASP 7; CASP-7; CASP7; CASP7_HUMAN; Caspase 7; Caspase 7 apoptosis related cysteine peptidase; Caspase-7 subunit p11; Caspase7; CMH 1; CMH-1; CMH1; CMH1; ICE LAP3; ICE like Apoptotic Protease 3; ICE-LAP3; ICE-like apoptotic protease 3; LICE2; MCH3; MCH3; caspase 7, apoptosis-related cysteine peptidase
Clonality
Polyclonal
Species Reactivity
Human, Rat
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen Affinity Purified
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
31,614 Da
OMIM
601761
3D Structure
ModBase 3D Structure for P55210
Immunogen
E Coli-derived human Caspase-7 recombinant protein (Position: A117-D198). Human Caspase-7 shares 92.7% amino acid (aa) sequence identity with both mouse and rat Caspase-7.
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CASP7 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Application Notes for anti-CASP7 antibody
Western Blot Concentration: 0.1-0.5ug/ml
Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml

Western Blot (WB) of anti-CASP7 antibody

Anti- Caspase-7 Picoband antibody, MBS177767, Western blotting
All lanes: Anti Caspase-7(MBS177767) at 0.5ug/ml
Lane 1: A549 Whole Cell Lysate at 40ug
Lane 2: Rat Spleen Tissue Lysate at 50ug
Lane 3: Rat Lung Tissue Lysate at 50ug
Predicted bind size: 34KD
Observed bind size: 34KD
Anti-CASP7 Polyclonal Antibody – Cat# MBS177767

Immunohistochemistry (IHC) of anti-CASP7 antibody

Anti- Caspase-7 Picoband antibody, MBS177767,IHC(P)
IHC(P): Human Mammary Cancer Tissue
Anti-CASP7 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS177767

Product References and Citations for anti-CASP7 antibody

1. Burguillos, M. A., Deierborg, T., Kavanagh, E., Persson, A., Hajji, N., Garcia-Quintanilla, A., Cano, J., Brundin, P., Englund, E., Venero, J. L., Joseph, B. Caspase signalling controls microglia activation and neurotoxicity. Nature 472: 319-324, 2011. 2. Soung, Y. H., Lee, J. W., Kim, H. S., Park, W. S., Kim, S. Y., Lee, J. H., Park, J. Y., Cho, Y. G., Kim, C. J., Park, Y. G., Nam, S. W., Jeong, S. W., Kim, S. H., Lee, J. Y., Yoo, N. J., Lee, S. H. Inactivating mutations of CASPASE-7 gene in human cancers. Oncogene 22: 8048-8052, 2003. 3. Tiso, N., Pallavicini, A., Muraro, T., Zimbello, R., Apolloni, E., Valle, G., Lanfranchi, G., Danieli, G. A. Chromosomal localization of the human genes, CPP32, Mch2, Mch3, and Ich-1, involved in cellular apoptosis. Biochem. Biophys. Res. Commun. 225: 983-989, 1996.

Other Notes

Small volumes of anti-CASP7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CASP7 purchase

MBS177767 is an antibody targeting CASP7. Also known as Anti-Caspase-7 Antibody. Reactive in Human, Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for CASP7. It may not necessarily be applicable to this product.

NCBI GI #
4502581
NCBI GeneID
840
NCBI Accession #
NP_001218.1
UniProt Primary Accession #
P55210
UniProt Secondary Accession #
Q13364; Q53YD5; Q5SVL0; Q5SVL3; Q96BA0; B4DQU7; B5BU45; D3DRB8
UniProt Related Accession #
P55210
GenBank Nucleotide #
NM_001227.4
NCBI Official Full Name
caspase-7 isoform alpha
NCBI Official Synonym Full Names
caspase 7
NCBI Official Symbol
CASP7
NCBI Official Synonym Symbols
MCH3; CMH-1; LICE2; CASP-7; ICE-LAP3
UniProt Protein Name
Caspase-7
UniProt Synonym Protein Names
Apoptotic protease Mch-3; CMH-1; ICE-like apoptotic protease 3; ICE-LAP3
Protein Family
Caspase
UniProt Gene Name
CASP7
UniProt Synonym Gene Names
MCH3; CASP-7; ICE-LAP3
UniProt Entry Name
CASP7_HUMAN
NCBI Protein Information
caspase-7

NCBI Summary for CASP7

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
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UniProt Comments for CASP7

Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

Research Articles on CASP7

1. this report suggests a novel finding that cellular signaling caspase 3/7-PKCdelta-Akt/p38 MAPK is crucial to the repopulation in Panc1 cells after radiotherapy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CASP7 antibody

 Reference Product  PubMed Publications
 CASP8 antibody  >312 publications with CASP7 and CASP8
 XIAP antibody  >90 publications with CASP7 and XIAP
 BIRC5 antibody  >50 publications with CASP7 and BIRC5
 PARP1 antibody  >50 publications with CASP7 and PARP1
 APAF1 antibody  >37 publications with CASP7 and APAF1
 GZMB antibody  >13 publications with CASP7 and GZMB
 CASP2 antibody  >12 publications with CASP7 and CASP2
 BIRC2 antibody  >8 publications with CASP7 and BIRC2
 RB1 antibody  >5 publications with CASP7 and RB1
 BIRC3 antibody  >5 publications with CASP7 and BIRC3

Pathways associated with anti-CASP7 antibody

 Products by Pathway  Pathway Diagram
 Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway antibodies  Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis - Multiple Species Pathway antibodies  Apoptosis - Multiple Species Pathway Diagram
 Apoptosis - Multiple Species Pathway antibodies  Apoptosis - Multiple Species Pathway Diagram

Diseases associated with anti-CASP7 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >288 publications with CASP7 and Necrosis
 Breast Neoplasms Antibodies  >192 publications with CASP7 and Breast Neoplasms
 Inflammation Antibodies  >118 publications with CASP7 and Inflammation
 Nervous System Diseases Antibodies  >95 publications with CASP7 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >70 publications with CASP7 and Neoplasms, Experimental
 Prostatic Neoplasms Antibodies  >68 publications with CASP7 and Prostatic Neoplasms
 Liver Diseases Antibodies  >67 publications with CASP7 and Liver Diseases
 Cardiovascular Diseases Antibodies  >61 publications with CASP7 and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >41 publications with CASP7 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >40 publications with CASP7 and Liver Neoplasms

Organs/Tissues associated with anti-CASP7 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >209 publications with CASP7 and Blood
 Lung Antibodies  >141 publications with CASP7 and Lung
 Brain Antibodies  >134 publications with CASP7 and Brain
 Liver Antibodies  >132 publications with CASP7 and Liver
 Muscle Antibodies  >86 publications with CASP7 and Muscle
 Prostate Antibodies  >83 publications with CASP7 and Prostate
 Vascular Antibodies  >80 publications with CASP7 and Vascular
 Kidney Antibodies  >75 publications with CASP7 and Kidney
 Heart Antibodies  >68 publications with CASP7 and Heart
 Nerve Antibodies  >66 publications with CASP7 and Nerve
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