Mitofusin 1 (MFN1) Antibody – Polyclonal

Description: Rabbit IgG polyclonal antibody for Mitofusin-1(MFN1) detection. Tested with WB in Human;Mouse;Rat.

Background: Mitofusin-1 is a protein that in humans is encoded by the MFN1 gene. It is an 80-90 kDa mitochondrial member of the dynamin family of molecules. It is ubiquitously expressed, and found in the outer mitochondrial membrane. The protein encoded by this gene is a mediator of mitochondrial fusion, and thereby contribute to the dynamic balance between fusion and fission that determines mitochondria morphology. MFN1 is known to form oligomers, either with itself or MFN-2, and to undergo ubiquitination by MARCH5. MFN-1 has two key domains. One is a coiled-coil region that mediates MFN-1: MFN-1/2 binding, and a second is a GTPase domain whose cleavage of GTP is necessary for membrane fusion. Overexpression of MFN1 caused perinuclear mitochondrial clustering.

1. Adams MD, Kerlavage AR, Fields C, Venter JC (Sep 1993). "3,400 new expressed sequence tags identify diversity of transcripts in human brain". Nat Genet 4 (3): 256-67. 2. Meeusen, S., McCaffery, J. M., Nunnari, J. Mitochondrial fusion intermediates revealed in vitro. Science 305: 1747-1752, 2004. 3. Santel, A., Fuller, M. T. Control of mitochondrial morphology by a human mitofusin. J. Cell Sci. 114: 867-874, 2001.

Small volumes of anti-MFN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS177769 is an antibody targeting MFN1. Also known as Anti-Mitofusin 1 Antibody. Reactive in Human, Mouse, Rat.