SOX4 Antibody – Polyclonal

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. [provided by RefSeq, Jul 2008]

SOX4: Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 6p22.3

Cellular Component: cytoplasm; mitochondrion; nucleoplasm; nucleus

Molecular Function: protein binding; protein heterodimerization activity; transcription factor activity

Biological Process: DNA damage response, detection of DNA damage; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; endocrine pancreas development; glial cell development; glial cell proliferation; glucose homeostasis; heart development; limb bud formation; negative regulation of cell proliferation; negative regulation of protein export from nucleus; negative regulation of protein ubiquitination; neural tube formation; positive regulation of apoptosis; positive regulation of cell proliferation; positive regulation of insulin secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of translation; positive regulation of Wnt receptor signaling pathway; pro-B cell differentiation; protein stabilization; regulation of protein stability; regulation of transcription, DNA-dependent; skeletal development; somatic stem cell maintenance; spinal cord development; spinal cord motor neuron differentiation; sympathetic nervous system development; T cell differentiation; transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin