SMC3 Antibody – Polyclonal

This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008]

SMC3: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement. Interacts with MXI1, MXD3 and MXD4. Interacts with SYCP2. Found in a complex with SMC1A, CDCA5 and RAD21, PDS5A/APRIN and PDS5B/SCC-112. Forms a heterodimer with SMC1A or SMC1B in cohesin complexes. Cohesin complexes are composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domain, RAD21 which link them, and one STAG protein (STAG1, STAG2 or STAG3), which interacts with RAD21. Also found in meiosis-specific cohesin complexes. Interacts with NUMA1, and forms a ternary complex with KIF3B and KIFAP3, suggesting a function in tethering the chromosomes to the spindle pole and in chromosome movement. Interacts with PDS5A and WAPAL; regulated by SMC3 acetylation. Belongs to the SMC family. SMC3 subfamily.

Protein type: DNA repair, damage; Cell cycle regulation

Chromosomal Location of Human Ortholog: 10q25

Cellular Component: basement membrane; chromatin; chromosome; chromosome, pericentric region; cohesin complex; cohesin core heterodimer; cytoplasm; cytosol; lateral element; nuclear matrix; nucleoplasm; nucleus; spindle pole

Molecular Function: ATP binding; chromatin binding; dynein binding; microtubule motor activity; protein binding; protein heterodimerization activity

Biological Process: cell division; DNA repair; meiosis; mitosis; mitotic sister chromatid cohesion; mitotic spindle organization and biogenesis; negative regulation of DNA endoreduplication; protein sumoylation; regulation of DNA replication; signal transduction; sister chromatid cohesion; stem cell maintenance

Disease: Cornelia De Lange Syndrome 3