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CD153 Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS177945

Description: Rabbit IgG polyclonal antibody for Tumor necrosis factor ligand superfamily member 8(TNFSF8) detection. Tested with IHC-P in Human.Background: CD153 is a ligand for CD30. The protein encoded by this gene is a cytokine that belongs to the tumor… More details

$210 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CD153, Polyclonal Antibody
Full Product Name
Anti-CD153 Antibody
Product Gene Name
anti-CD153 antibody
Product Synonym Names
Tumor necrosis factor ligand superfamily member 8; CD153; CD153 antigen; CD30 antigen ligand; CD30 L; CD30 ligand; CD30-L; CD30L; CD30LG; MGC138144; TNFL8_HUMAN; Tnfsf8; Tumor necrosis factor (ligand) superfamily member 8; Tumor necrosis factor ligand superfamily member 8; tumor necrosis factor superfamily member 8
Clonality
Polyclonal
Species Reactivity
Human
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen Affinity Purified
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
26,017 Da
OMIM
603875
3D Structure
ModBase 3D Structure for P32971
Immunogen
E Coli-derived human CD153 recombinant protein (Position: Q63-D234). Human CD153 shares 75% amino acid (aa) sequence identity with mouse CD153.
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CD153 antibody
Immunohistochemistry (IHC) Paraffin
Application Notes for anti-CD153 antibody
Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml

Immunohistochemistry (IHC) of anti-CD153 antibody

CD153 was detected in paraffin-embedded sections of human tonsil tissues using rabbit anti- CD153 Antigen Affinity purified polyclonal antibody at 1 ug/mL. The immunohistochemical section was developed using SABC method.
Anti-CD153 Polyclonal Antibody – Cat# MBS177945

Testing Data of anti-CD153 antibody

Anti-CD153 Polyclonal Antibody, Testing Data – Cat# MBS177945

Product References and Citations for anti-CD153 antibody

1. Cerutti, A., Schaffer, A., Goodwin, R. G., Shah, S., Zan, H., Ely, S., Casali, P. Engagement of CD153 (CD30 ligand) by CD30-positive T cells inhibits class switch DNA recombination and antibody production in human IgD-positive IgM-positive B cells. J. Immun. 165: 786-794, 2000. 2. Croager, E. J., Abraham, L. J. Characterisation of the human CD30 ligand gene structure. Biochim. Biophys. Acta 1353: 231-235, 1997. 3. Fischer, M., Harvima, I. T., Carvalho, R. F. S., Moller, C., Naukkarinen, A., Enblad, G., Nilsson, G. Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion. J. Clin. Invest. 116: 2748-2756, 2006.

Other Notes

Small volumes of anti-CD153 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD153 purchase

MBS177945 is an antibody targeting CD153. Reactive in Human.

Additional Details

NCBI/Uniprot data below describe general gene information for CD153. It may not necessarily be applicable to this product.

NCBI GI #
4507607
NCBI GeneID
944
NCBI Accession #
NP_001235.1
UniProt Primary Accession #
P32971
UniProt Secondary Accession #
O43404
UniProt Related Accession #
P32971
GenBank Nucleotide #
NM_001244.3
NCBI Official Full Name
tumor necrosis factor ligand superfamily member 8 isoform 1
NCBI Official Synonym Full Names
tumor necrosis factor superfamily member 8
NCBI Official Symbol
TNFSF8
NCBI Official Synonym Symbols
CD153; CD30L; CD30LG; TNLG3A
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 8
UniProt Synonym Protein Names
CD30 ligand; CD30-L; CD_antigen: CD153
Protein Family
Tumor necrosis factor ligand superfamily
UniProt Gene Name
TNFSF8
UniProt Synonym Gene Names
CD30L; CD30LG; CD30-L
UniProt Entry Name
TNFL8_HUMAN
NCBI Protein Information
tumor necrosis factor ligand superfamily member 8

NCBI Summary for CD153

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
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UniProt Comments for CD153

TNFSF8: Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells. Belongs to the tumor necrosis factor family.

Protein type: Membrane protein, integral; Cytokine; Apoptosis

Chromosomal Location of Human Ortholog: 9q33

Cellular Component: extracellular space; integral to plasma membrane

Molecular Function: cytokine activity; receptor binding; tumor necrosis factor receptor binding

Biological Process: apoptosis; CD8-positive, alpha-beta T cell differentiation; cell proliferation; cell-cell signaling; defense response to Gram-positive bacterium; immune response; positive regulation of transcription from RNA polymerase II promoter; signal transduction
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Research Articles on CD153

1. circulant sCD30L is functionally active and that it may favor persistence of active inflammation by inducing apoptosis of CD30(+)T cells, known to down-modulate inflammation in rheumatoid synovitis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD153 antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with anti-CD153 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >61 publications with CD153 and Necrosis
 Inflammation Antibodies  >9 publications with CD153 and Inflammation
 Lung Diseases Antibodies  >6 publications with CD153 and Lung Diseases
 Cardiovascular Diseases Antibodies  >5 publications with CD153 and Cardiovascular Diseases
 Skin Neoplasms Antibodies  >5 publications with CD153 and Skin Neoplasms
 Lung Neoplasms Antibodies  >3 publications with CD153 and Lung Neoplasms
 Heart Diseases Antibodies  >3 publications with CD153 and Heart Diseases
 Breast Neoplasms Antibodies  >2 publications with CD153 and Breast Neoplasms
 Liver Diseases Antibodies  >2 publications with CD153 and Liver Diseases
 Nervous System Diseases Antibodies  >2 publications with CD153 and Nervous System Diseases

Organs/Tissues associated with anti-CD153 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >74 publications with CD153 and Blood
 Spleen Antibodies  >11 publications with CD153 and Spleen
 Lymph Node Antibodies  >9 publications with CD153 and Lymph Node
 Lung Antibodies  >6 publications with CD153 and Lung
 Thymus Antibodies  >5 publications with CD153 and Thymus
 Heart Antibodies  >4 publications with CD153 and Heart
 Bone Marrow Antibodies  >4 publications with CD153 and Bone Marrow
 Placenta Antibodies  >2 publications with CD153 and Placenta
 Pharynx Antibodies  >2 publications with CD153 and Pharynx
 Brain Antibodies  >1 publications with CD153 and Brain
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