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CCL3 Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS177978

Description: Rabbit IgG polyclonal antibody for C-C motif chemokine 3(CCL3) detection. Tested with WB, ELISA in Human.Background: Macrophage inflammatory protein-1 alpha (MIP-1 alpha), also called CCL3, LD78. The cDNA for CCL3 predicts a mature peptide of 69… More details

$210 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CCL3, Polyclonal Antibody
Full Product Name
Anti-CCL3 Antibody
Product Gene Name
anti-CCL3 antibody
Product Synonym Names
C-C motif chemokine 3; C C motif chemokine 3; CCL 3; CCL3; CCL3_HUMAN; Chemokine C; C motif ligand 3; Chemokine CC Motif Ligand 3; G0/G1 switch regulatory protein 19 1; G0/G1 switch regulatory protein 19-1; G0S19 1; G0S19 1 protein; Heparin binding chemotaxis protein; L2G25B; LD78 alpha; LD78-alpha(4-69); LD78ALPHA; Macrophage inflammatory protein 1 alpha; Macrophage inflammatory protein 1-alpha; MIP 1 alpha; MIP 1A; MIP-1-alpha; MIP-1-alpha(4-69); MIP1A; PAT 464.1; SCYA 3; SCYA3; SIS alpha; SIS beta; SIS-beta; Small inducible cytokine A3; Small-inducible cytokine A3; Tonsillar lymphocyte LD78 alpha protein; chemokine (C-C motif) ligand 3
Clonality
Polyclonal
Species Reactivity
Human
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen Affinity Purified
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
OMIM
182283
3D Structure
ModBase 3D Structure for P10147
Immunogen
E Coli-derived human CCL3 recombinant protein (Position: S24-A92). Human CCL3 shares 75.8% and 77.3% amino acid (aa) sequence identity with mouse and rat CCL3, respectively.
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CCL3 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CCL3 antibody
Western Blot (WB): Concentration: 0.1-0.5ug/ml; Tested Species: Human
ELISA (EIA): Concentration: 0.1 -0.5ug/ml; Tested Species: Human

Tested Species: In house tested species with positive results.
Other applications have not been tested.
Optimal dilutions should be determined by end users.

Western Blot (WB) of anti-CCL3 antibody

Anti- CCL3 Picoband antibody, MBS177978), Western blotting
All lanes: Anti CCL3 (MBS177978) at 0.5ug/ml
WB: JURKAT Whole Cell Lysate at 40ug
Predicted bind size: 11KD
Observed bind size: 11KD
Anti-CCL3 Polyclonal Antibody – Cat# MBS177978

Product References and Citations for anti-CCL3 antibody

1. Cook, D. N.; Beck, M. A.; Coffman, T. M.; Kirby, S. L.; Sheridan, J. F.; Pragnell, I. B.; Smithies, O. Requirement of MIP-1-alpha for an inflammatory response to viral infection. Science 269: 1583-1585, 1995. 2. Miyazaki, D.; Nakamura, T.; Toda, M.; Cheung-Chau, K.-W.; Richardson, R. M.; Ono, S. J. Macrophage inflammatory protein-1-alpha as a costimulatory signal for mast cell-mediated immediate hypersensitivity reactions. J. Clin. Invest. 115: 434-442, 2005. 3. Nakao, M.; Nomiyama, H.; Shimada, K. Structures of human genes coding for cytokine LD78 and their expression. Molec. Cell. Biol. 10: 3646-3658, 1990. 4. Wolpe, S. D.; Cerami, A. Macrophage inflammatory proteins 1 and 2: members of a novel superfamily of cytokines. FASEB J. 3: 2565-2573, 1989.

Other Notes

Small volumes of anti-CCL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL3 purchase

MBS177978 is an antibody targeting CCL3. Reactive in Human.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL3. It may not necessarily be applicable to this product.

NCBI GI #
4506843
NCBI GeneID
6348
NCBI Accession #
NP_002974.1
UniProt Primary Accession #
P10147
UniProt Related Accession #
P10147
GenBank Nucleotide #
NM_002983.2
NCBI Official Full Name
C-C motif chemokine 3
NCBI Official Synonym Full Names
C-C motif chemokine ligand 3
NCBI Official Symbol
CCL3
NCBI Official Synonym Symbols
MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha
UniProt Protein Name
C-C motif chemokine 3
UniProt Synonym Protein Names
G0/G1 switch regulatory protein 19-1; Macrophage inflammatory protein 1-alpha; MIP-1-alpha
Protein Family
C-C motif chemokine
UniProt Gene Name
CCL3
UniProt Synonym Gene Names
G0S19-1; MIP1A; SCYA3; MIP-1-alpha
UniProt Entry Name
CCL3_HUMAN
NCBI Protein Information
C-C motif chemokine 3

NCBI Summary for CCL3

This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]
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UniProt Comments for CCL3

CCL3: Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted, signal peptide; Secreted; Chemokine; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: cytoplasm; cytosol; extracellular region; extracellular space; intracellular

Molecular Function: calcium-dependent protein kinase C activity; CCR1 chemokine receptor binding; CCR5 chemokine receptor binding; chemoattractant activity; chemokine activity; identical protein binding; kinase activity; phospholipase activator activity; protein binding; protein kinase activity

Biological Process: astrocyte cell migration; behavior; calcium ion transport; calcium-mediated signaling; cell activation; cell-cell signaling; cellular calcium ion homeostasis; chemotaxis; cytoskeleton organization and biogenesis; eosinophil chemotaxis; eosinophil degranulation; exocytosis; G-protein coupled receptor protein signaling pathway; inflammatory response; lipopolysaccharide-mediated signaling pathway; lymphocyte chemotaxis; macrophage chemotaxis; MAPKKK cascade; monocyte chemotaxis; negative regulation of bone mineralization; negative regulation of osteoclast differentiation; neutrophil chemotaxis; osteoblast differentiation; positive chemotaxis; positive regulation of calcium ion transport; positive regulation of calcium-mediated signaling; positive regulation of cell migration; positive regulation of GTPase activity; positive regulation of inflammatory response; positive regulation of interleukin-1 beta secretion; positive regulation of neuron apoptosis; positive regulation of protein kinase B signaling cascade; positive regulation of tumor necrosis factor production; protein kinase B signaling cascade; regulation of cell shape; regulation of sensory perception of pain; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; response to toxin

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To
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Research Articles on CCL3

1. AEG-1 mediates CCL3/CCR5-induced EMT development via both Erk1/2 and Akt signaling pathway in CM patients, which indicates CCL3/CCR5-AEG-1-EMT pathway could be suggested as a useful target to affect the progression of CM.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCL3 antibody

 Reference Product  PubMed Publications
 CCL4 antibody  >1732 publications with CCL3 and CCL4
 CCR5 antibody  >547 publications with CCL3 and CCR5
 CCR1 antibody  >299 publications with CCL3 and CCR1
 CCR2 antibody  >154 publications with CCL3 and CCR2
 CCR3 antibody  >74 publications with CCL3 and CCR3
 CCR4 antibody  >52 publications with CCL3 and CCR4
 CXCR5 antibody  >6 publications with CCL3 and CXCR5
 IL12B antibody  >5 publications with CCL3 and IL12B
 IDE antibody  >5 publications with CCL3 and IDE
 CCBP2 antibody  >4 publications with CCL3 and CCBP2

Pathways associated with anti-CCL3 antibody

 Products by Pathway  Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 IL12-mediated Signaling Events Pathway antibodies  IL12-mediated Signaling Events Pathway Diagram

Diseases associated with anti-CCL3 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >988 publications with CCL3 and Inflammation
 Necrosis Antibodies  >554 publications with CCL3 and Necrosis
 Disease Models, Animal Antibodies  >346 publications with CCL3 and Disease Models, Animal
 Lung Diseases Antibodies  >258 publications with CCL3 and Lung Diseases
 HIV Infections Antibodies  >194 publications with CCL3 and HIV Infections
 Cardiovascular Diseases Antibodies  >188 publications with CCL3 and Cardiovascular Diseases
 Hypersensitivity Antibodies  >111 publications with CCL3 and Hypersensitivity
 Liver Diseases Antibodies  >106 publications with CCL3 and Liver Diseases
 Fibrosis Antibodies  >86 publications with CCL3 and Fibrosis
 Pneumonia Antibodies  >77 publications with CCL3 and Pneumonia

Organs/Tissues associated with anti-CCL3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1655 publications with CCL3 and Blood
 Lung Antibodies  >355 publications with CCL3 and Lung
 Brain Antibodies  >278 publications with CCL3 and Brain
 Liver Antibodies  >230 publications with CCL3 and Liver
 Kidney Antibodies  >89 publications with CCL3 and Kidney
 Heart Antibodies  >87 publications with CCL3 and Heart
 Intestine Antibodies  >59 publications with CCL3 and Intestine
 Eye Antibodies  >54 publications with CCL3 and Eye
 Uterus Antibodies  >21 publications with CCL3 and Uterus
 Placenta Antibodies  >19 publications with CCL3 and Placenta
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