• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

TrkB Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS177981

Description: Rabbit IgG polyclonal antibody for BDNF/NT-3 growth factors receptor(NTRK2) detection. Tested with WB in Human;Mouse;Rat.Background: TrkB is also known as NTRK2. This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK)… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
TrkB, Polyclonal Antibody
Full Product Name
Anti-TrkB Antibody
Product Gene Name
anti-TrkB antibody
Product Synonym Names
BDNF/NT-3 growth factors receptor; AI848316; BDNF tropomyosine receptor kinase B; BDNF/NT 3 growth factors receptor; BDNF/NT-3 growth factors receptor; Brain derived neurotrophic factor receptor; C030027L06Rik; EC 2.7.10.1; GP145 TrkB; GP145-TrkB; GP145-TrkB/GP95-TrkB; GP95 TrkB; Neurotrophic tyrosine kinase receptor type 2; Neurotrophin receptor tyrosine kinase type 2; NTRK 2; NTRK2; NTRK2_HUMAN; Obesity, hyperphagia, and developmental delay, included; RATTRKB1; Tkrb; Trk B; Trk-B; TRKB; TrkB tyrosine kinase; TRKB1; Tropomyosin related kinase B; tyrosine kinase receptor B; Tyrosine receptor kinase B; neurotrophic tyrosine kinase, receptor, type 2
Clonality
Polyclonal
Species Reactivity
Mouse, Rat
Predicted to work with: Human
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen Affinity Purified
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
35,332 Da
OMIM
600456
3D Structure
ModBase 3D Structure for Q16620
Immunogen
E Coli-derived human TrkB recombinant protein (Position: E66-E242). Human TrkB shares 91.5% and 89.8% amino acid (aa) sequence identity with mouse and rat TrkB, respectively.
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-TrkB antibody
Western Blot (WB)
Application Notes for anti-TrkB antibody
Western Blot Concentration: 0.1-0.5ug/ml

Western Blot (WB) of anti-TrkB antibody

Anti- TrkB Picoband antibody, MBS177981, Western blotting
All lanes: Anti TrkB (MBS177981) at 0.5ug/ml
Lane 1: Rat Brain Tissue Lysate at 50ug
Lane 2: Mouse Brain Tissue Lysate at 50ug
Predicted bind size: 92KD
Observed bind size: 120KD
Anti-TrkB Polyclonal Antibody – Cat# MBS177981

Product References and Citations for anti-TrkB antibody

1. Berghuis, P., Dobszay, M. B., Wang, X., Spano, S., Ledda, F., Sousa, K. M., Schulte, G., Ernfors, P., Mackie, K., Paratcha, G., Hurd, Y. L., Harkany, T. Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor. Proc. Nat. Acad. Sci. 102: 19115-19120, 2005. 2. Luberg, K., Wong, J., Weickert, C. S., Timmusk, T. Human TrkB gene: novel alterative transcripts, protein isoforms and expression pattern in the prefrontal cerebral cortex during postnatal development. J. Neurochem. 113: 952-964, 2010. 3. Nikoletopoulou, V., Lickert, H., Frade, J. M., Rencurel, C., Giallonardo, P., Zhang, L., Bibel, M., Barde, Y.-A. Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not. Nature 467: 59-63, 2010.

Other Notes

Small volumes of anti-TrkB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TrkB purchase

MBS177981 is an antibody targeting TrkB. Reactive in Mouse, Rat
Predicted to work with: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for TrkB. It may not necessarily be applicable to this product.

NCBI GI #
55956790
NCBI GeneID
4915
NCBI Accession #
NP_001007098.1
UniProt Primary Accession #
Q16620
UniProt Secondary Accession #
Q16675; Q59GJ1; Q8WXJ5; Q8WXJ6; Q8WXJ7; B1ANZ4; B4DFV9
UniProt Related Accession #
Q16620
GenBank Nucleotide #
NM_001007097.2
NCBI Official Full Name
BDNF/NT-3 growth factors receptor isoform b
NCBI Official Synonym Full Names
neurotrophic receptor tyrosine kinase 2
NCBI Official Symbol
NTRK2
NCBI Official Synonym Symbols
TRKB; trk-B; GP145-TrkB
UniProt Protein Name
BDNF/NT-3 growth factors receptor
UniProt Synonym Protein Names
GP145-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Tropomyosin-related kinase B
Protein Family
BDNF/NT-3 growth factors receptor
UniProt Gene Name
NTRK2
UniProt Synonym Gene Names
TRKB; Trk-B
UniProt Entry Name
NTRK2_HUMAN
NCBI Protein Information
BDNF/NT-3 growth factors receptor

NCBI Summary for TrkB

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Show more

UniProt Comments for TrkB

TrkB: a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described.

Protein type: Kinase, protein; EC 2.7.10.1; Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; Trk family

Chromosomal Location of Human Ortholog: 9q22.1

Cellular Component: cell surface; cytosol; dendritic spine; endosome membrane; growth cone; integral to plasma membrane; perikaryon; postsynaptic membrane; presynaptic active zone; receptor complex; rough endoplasmic reticulum; terminal button

Molecular Function: ATP binding; brain-derived neurotrophic factor binding; brain-derived neurotrophic factor receptor activity; neurotrophin binding; protein homodimerization activity; receptor tyrosine kinase binding

Biological Process: aging; brain-derived neurotrophic factor receptor signaling pathway; central nervous system neuron development; cerebral cortex development; circadian rhythm; feeding behavior; glutamate secretion; inflammatory response; learning; long-term memory; mechanoreceptor differentiation; negative regulation of neuron apoptosis; neuromuscular junction development; neuron differentiation; neuron migration; oligodendrocyte differentiation; peptidyl-tyrosine phosphorylation; peripheral nervous system neuron development; positive regulation of axonogenesis; positive regulation of cell proliferation; positive regulation of MAPKKK cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid phosphorylation; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; protein amino acid autophosphorylation; regulation of dendrite development; regulation of GTPase activity; regulation of neurotransmitter secretion; regulation of protein kinase B signaling cascade; response to light stimulus; retina development in camera-type eye; retinal rod cell development; vasculogenesis

Disease: Obesity, Hyperphagia, And Developmental Delay
Show more

Research Articles on TrkB

1. TrkB protein was mainly expressed in eutopic endometrium of proliferative phase with EMs than that in eutopic endometrium of secretory phase

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TrkB antibody

 Reference Product  PubMed Publications
 BDNF antibody  >121 publications with TrkB and BDNF
 NGFR antibody  >14 publications with TrkB and NGFR
 NTF3 antibody  >5 publications with TrkB and NTF3
 NTF4 antibody  >3 publications with TrkB and NTF4
 SH2B1 antibody  >1 publications with TrkB and SH2B1

Pathways associated with anti-TrkB antibody

 Products by Pathway  Pathway Diagram
 Activation Of TRKA Receptors Pathway antibodies  Activation Of TRKA Receptors Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 NGF Signalling Via TRKA From The Plasma Membrane Pathway antibodies  NGF Signalling Via TRKA From The Plasma Membrane Pathway Diagram
 NGF-independant TRKA Activation Pathway antibodies  NGF-independant TRKA Activation Pathway Diagram
 Neurotrophic Factor-mediated Trk Receptor Signaling Pathway antibodies  Neurotrophic Factor-mediated Trk Receptor Signaling Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram

Diseases associated with anti-TrkB antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >31 publications with TrkB and Nervous System Diseases
 Disease Models, Animal Antibodies  >21 publications with TrkB and Disease Models, Animal
 Depressive Disorder Antibodies  >15 publications with TrkB and Depressive Disorder
 Obesity Antibodies  >14 publications with TrkB and Obesity
 Neuroblastoma Antibodies  >11 publications with TrkB and Neuroblastoma
 Bipolar Disorder Antibodies  >11 publications with TrkB and Bipolar Disorder
 Glioma Antibodies  >9 publications with TrkB and Glioma
 Memory Disorders Antibodies  >8 publications with TrkB and Memory Disorders
 Hyperphagia Antibodies  >7 publications with TrkB and Hyperphagia
 Lung Neoplasms Antibodies  >6 publications with TrkB and Lung Neoplasms

Organs/Tissues associated with anti-TrkB antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >137 publications with TrkB and Brain
 Nerve Antibodies  >52 publications with TrkB and Nerve
 Lung Antibodies  >14 publications with TrkB and Lung
 Ovary Antibodies  >8 publications with TrkB and Ovary
 Heart Antibodies  >5 publications with TrkB and Heart
 Kidney Antibodies  >5 publications with TrkB and Kidney
 Bone Antibodies  >5 publications with TrkB and Bone
 Thyroid Antibodies  >4 publications with TrkB and Thyroid
 Prostate Antibodies  >4 publications with TrkB and Prostate
 Embryonic Tissue Antibodies  >4 publications with TrkB and Embryonic Tissue
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000