Anti-MMP14 Polyclonal Antibody – Cat# MBS178051

Anti- MMP14 Picoband antibody, MBS178051, Western blotting
All lanes: Anti MMP14 (MBS178051) at 0.5ug/ml
Lane 1: Human Placenta Tissue Lysate at 50ug
Lane 2: HELA Whole Cell Lysate at 40ug
Lane 3: U87 Whole Cell Lysate at 40ug
Predicted bind size: 55KD
Observed bind size: 55KD

MMP14 Antibody – Polyclonal

Name: MMP14 Antibody; Polyclonal; Human-Reactive; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS178051
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178051

Description: Rabbit IgG polyclonal antibody for Matrix metalloproteinase-14(MMP14) detection. Tested with WB in Human.Background: Matrix metalloproteinase-14, also called MT-MMP 1, is an enzyme that in humans is encoded by the MMP14 gene. The protein encoded… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MMP14, Polyclonal Antibody

Full Product Name

Anti-MMP14 Antibody

Product Gene Name

anti-MMP14 antibody

Product Synonym Names

Matrix metalloproteinase-14; Matrix metallopeptidase 14 (membrane inserted); Matrix metalloproteinase 14; Matrix metalloproteinase-14; Membrane type 1 matrix metalloproteinase; Membrane type 1 metalloprotease; Membrane type matrix metalloproteinase 1; Membrane-type matrix metalloproteinase 1; Membrane-type-1 matrix metalloproteinase; MMP 14; MMP X1; MMP-14; MMP-X1; Mmp14; MMP14_HUMAN; MMPX1; MT MMP 1; MT-MMP 1; MT1 MMP; MT1-MMP; MT1MMP; MTMMP 1; MTMMP1; matrix metallopeptidase 14 (membrane-inserted)

Clonality

Polyclonal

Species Reactivity

Human

Form/Format

Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purity/Purification

Immunogen Affinity Purified

Preparation and Storage

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Molecular Weight

65,894 Da

OMIM

277950

3D Structure

ModBase 3D Structure for P50281

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human MMP14 (557-582aa LAVFFFRRHGTPRRLLYCQRSLLDKV), different from the related mouse and rat sequences by one amino acid.

Ig Type

Rabbit IgG

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-MMP14 antibody

Western Blot (WB)

Application Notes for anti-MMP14 antibody

Western Blot Concentration: 0.1-0.5ug/ml

Product References and Citations for anti-MMP14 antibody

1. Chun, T.-H., Hotary, K. B., Sabeh, F., Saltiel, A. R., Allen, E. D., Weiss, S. J. A pericellular collagenase directs the 3-dimensional development of white adipose tissue. Cell 125: 577-591, 2006. 2. Oh, J., Takahashi, R., Adachi, E., Kondo, S., Kuratomi, S., Noma, A., Alexander, D. B., Motoda, H., Okada, A., Seiki, M., Itoh, T., Itohara, S., Takahashi, C., Noda, M. Mutations in two matrix metalloproteinase genes, MMP-2, and MT1-MMP, are synthetic lethal in mice. Oncogene 23: 5041-5048, 2004. 3. Ueda, M., Yamashita, Y., Takehara, M., Terai, Y., Kumagai, K., Ueki, K., Kanda, K., Yamaguchi, H., Akise, D., Hung, Y.-C., Ueki, M. Survivin gene expression in endometriosis. J. Clin. Endocr. Metab. 87: 3452-3459, 2002.

Other Notes

Small volumes of anti-MMP14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MMP14 purchase

MBS178051 is an antibody targeting MMP14. Reactive in Human.

Additional Details

NCBI/Uniprot data below describe general gene information for MMP14. It may not necessarily be applicable to this product.

NCBI GI #

4826834

NCBI GeneID

4323

NCBI Accession #

NP_004986.1

UniProt Primary Accession #

P50281

UniProt Secondary Accession #

Q6GSF3; Q92678; A8K5L0

UniProt Related Accession #

P50281

GenBank Nucleotide #

NM_004995.3

NCBI Official Full Name

matrix metalloproteinase-14 preproprotein

NCBI Official Synonym Full Names

matrix metallopeptidase 14

NCBI Official Symbol

MMP14

NCBI Official Synonym Symbols

MMP-14; MMP-X1; MT-MMP; MT1MMP; MTMMP1; WNCHRS; MT1-MMP; MT-MMP 1

UniProt Protein Name

Matrix metalloproteinase-14

UniProt Synonym Protein Names

MMP-X1; Membrane-type matrix metalloproteinase 1; MT-MMP 1; MTMMP1; Membrane-type-1 matrix metalloproteinase; MT1-MMP; MT1MMP

Protein Family

Matrix metalloproteinase

UniProt Gene Name

MMP14

UniProt Synonym Gene Names

MMP-14; MT-MMP 1; MTMMP1; MT1-MMP; MT1MMP

UniProt Entry Name

MMP14_HUMAN

NCBI Protein Information

matrix metalloproteinase-14

NCBI Summary for MMP14

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]

UniProt Comments for MMP14

Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2.

Research Articles on MMP14

1. Data indicate that microRNA miR-335 can regulate cell surface membrane-type 1 matrix metalloproteinase (MT1-MMP) levels in some tumor cells, a property accompanied by increased motility and proliferation in these cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MMP14 antibody

Reference Product	PubMed Publications
MMP2 antibody	>174 publications with MMP14 and MMP2
TIMP2 antibody	>55 publications with MMP14 and TIMP2
TIMP1 antibody	>36 publications with MMP14 and TIMP1
FURIN antibody	>14 publications with MMP14 and FURIN
SP1 antibody	>7 publications with MMP14 and SP1
LUM antibody	>3 publications with MMP14 and LUM
ADI1 antibody	>1 publications with MMP14 and ADI1

Pathways associated with anti-MMP14 antibody

Products by Pathway	Pathway Diagram
AGE/RAGE Pathway antibodies	AGE/RAGE Pathway Diagram
Activation Of Matrix Metalloproteinases Pathway antibodies	Activation Of Matrix Metalloproteinases Pathway Diagram
Collagen Degradation Pathway antibodies	Collagen Degradation Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
GnRH Signaling Pathway antibodies	GnRH Signaling Pathway Diagram
GnRH Signaling Pathway antibodies	GnRH Signaling Pathway Diagram
HIF-2-alpha Transcription Factor Network Pathway antibodies	HIF-2-alpha Transcription Factor Network Pathway Diagram
Matrix Metalloproteinases Pathway antibodies	Matrix Metalloproteinases Pathway Diagram
Senescence And Autophagy Pathway antibodies	Senescence And Autophagy Pathway Diagram

Diseases associated with anti-MMP14 antibody

Disease Name	Pubmed Publications
Neoplasm Invasiveness Antibodies	>141 publications with MMP14 and Neoplasm Invasiveness
Neoplasm Metastasis Antibodies	>106 publications with MMP14 and Neoplasm Metastasis
Breast Neoplasms Antibodies	>76 publications with MMP14 and Breast Neoplasms
Disease Models, Animal Antibodies	>61 publications with MMP14 and Disease Models, Animal
Adenocarcinoma Antibodies	>51 publications with MMP14 and Adenocarcinoma
Inflammation Antibodies	>49 publications with MMP14 and Inflammation
Cardiovascular Diseases Antibodies	>41 publications with MMP14 and Cardiovascular Diseases
Neoplasms, Experimental Antibodies	>38 publications with MMP14 and Neoplasms, Experimental
Lung Diseases Antibodies	>37 publications with MMP14 and Lung Diseases
Lung Neoplasms Antibodies	>31 publications with MMP14 and Lung Neoplasms

Organs/Tissues associated with anti-MMP14 antibody

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>123 publications with MMP14 and Vascular
Blood Antibodies	>103 publications with MMP14 and Blood
Bone Antibodies	>73 publications with MMP14 and Bone
Lung Antibodies	>66 publications with MMP14 and Lung
Muscle Antibodies	>52 publications with MMP14 and Muscle
Embryonic Tissue Antibodies	>40 publications with MMP14 and Embryonic Tissue
Brain Antibodies	>39 publications with MMP14 and Brain
Connective Tissue Antibodies	>38 publications with MMP14 and Connective Tissue
Heart Antibodies	>31 publications with MMP14 and Heart
Skin Antibodies	>28 publications with MMP14 and Skin