Anti-PINX1 Polyclonal Antibody – Cat# MBS178066

Anti- PINX1 Picoband antibody, MBS178066, Western blotting
All lanes: Anti PINX1 (MBS178066) at 0.5ug/ml
Lane 1: Human Placenta Tissue Lysate at 50ug
Lane 2: HELA Whole Cell Lysate at 40ug
Lane 3: HUT Whole Cell Lysate at 40ug
Lane 4: JURKAT Whole Cell Lysate at 40ug
Predicted bind size: 37KD
Observed bind size: 37KD

PINX1 Antibody – Polyclonal

Name: PINX1 Antibody; Polyclonal; Human-Reactive; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS178066
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178066

Description: Rabbit IgG polyclonal antibody for PIN2/TERF1-interacting telomerase inhibitor 1(PINX1) detection. Tested with WB in Human.Background: PINX1, also known as PIN2 interacting protein 1, is a telomerase inhibitor and a possible tumor suppressor. It… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PINX1, Polyclonal Antibody

Full Product Name

Anti-PINX1 Antibody

Product Gene Name

anti-PINX1 antibody

Product Synonym Names

PIN2/TERF1-interacting telomerase inhibitor 1; 67-11-3 protein antibodyFLJ20565; Hepatocellular carcinoma-related putative tumor suppressor; Liver-related putative tumor suppressor; LPTL; LPTS; MGC8850; OTTHUMP00000224984; OTTHUMP00000224985; OTTHUMP00000224986; OTTHUMP00000225053; OTTHUMP00000225054; PIN2 interacting protein 1; Pin2-interacting protein X1; PIN2/TERF1-interacting telomerase inhibitor 1; PINX1; PINX1_HUMAN; Protein 67-11-3; TRF1-interacting protein 1; PIN2/TERF1 interacting, telomerase inhibitor 1

Clonality

Polyclonal

Species Reactivity

Human

Form/Format

Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purity/Purification

Immunogen Affinity Purified

Preparation and Storage

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Molecular Weight

19,714 Da

OMIM

606505

3D Structure

ModBase 3D Structure for Q96BK5

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human PINX1 (54-83aa DHIKVQVKNNHLGLGATINNEDNWIAHQDD), different from the related mouse and rat sequences by three amino acids.

Ig Type

Rabbit IgG

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-PINX1 antibody

Western Blot (WB)

Application Notes for anti-PINX1 antibody

Western Blot Concentration: 0.1-0.5ug/ml

Product References and Citations for anti-PINX1 antibody

1. Banik, S.S.R.; Counter, C.M. (September 2004). "Characterization of Interactions between PinX1 and Human Telomerase Subunits hTERT and hTR". Journal of Biological Chemistry. 2. Zhou, X Z; Lu K P (Nov 2001). "The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor". Cell (United States) 107 (3): 347-59.

Other Notes

Small volumes of anti-PINX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PINX1 purchase

MBS178066 is an antibody targeting PINX1. Reactive in Human.

Additional Details

NCBI/Uniprot data below describe general gene information for PINX1. It may not necessarily be applicable to this product.

NCBI GI #

547234890

NCBI GeneID

54984

NCBI Accession #

NP_001271285.1

UniProt Primary Accession #

Q96BK5

UniProt Secondary Accession #

Q548A5; Q6QWG9; Q7Z7J8; Q96QD7; Q9HBU7; Q9NWW2; B2R9B1

UniProt Related Accession #

Q96BK5

GenBank Nucleotide #

NM_001284356.1

NCBI Official Full Name

PIN2/TERF1-interacting telomerase inhibitor 1 isoform 2

NCBI Official Synonym Full Names

PIN2/TERF1 interacting, telomerase inhibitor 1

NCBI Official Symbol

PINX1

NCBI Official Synonym Symbols

LPTL; LPTS

UniProt Protein Name

PIN2/TERF1-interacting telomerase inhibitor 1

UniProt Synonym Protein Names

Liver-related putative tumor suppressor; Pin2-interacting protein X1; Protein 67-11-3; TRF1-interacting protein 1

Protein Family

PIN2/TERF1-interacting telomerase inhibitor

UniProt Gene Name

PINX1

UniProt Synonym Gene Names

LPTL; LPTS

UniProt Entry Name

PINX1_HUMAN

NCBI Protein Information

PIN2/TERF1-interacting telomerase inhibitor 1

UniProt Comments for PINX1

PINX1: Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. Belongs to the PINX1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor; Tumor suppressor; Nucleolus

Chromosomal Location of Human Ortholog: 8p23

Cellular Component: cytoplasm; intracellular membrane-bound organelle; kinetochore; mitochondrion; nuclear chromosome; nuclear chromosome, telomeric region; nucleolus; nucleus; spindle

Molecular Function: protein binding

Biological Process: mitotic metaphase plate congression; negative regulation of cell proliferation; negative regulation of protein ubiquitination; negative regulation of telomerase activity; negative regulation of telomere maintenance via telomerase; regulation of protein stability; regulation of telomerase activity; telomere maintenance via telomerase

Research Articles on PINX1

1. PinX1 protein expression is decreased in colorectal cancer patients and predicts a poor prognosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PINX1 antibody

Reference Product	PubMed Publications
TERT antibody	>14 publications with PINX1 and TERT
TERF1 antibody	>3 publications with PINX1 and TERF1
TFIP11 antibody	>1 publications with PINX1 and TFIP11

Pathways associated with anti-PINX1 antibody

Products by Pathway	Pathway Diagram
Regulation Of Telomerase Pathway antibodies	Regulation Of Telomerase Pathway Diagram

Diseases associated with anti-PINX1 antibody

Disease Name	Pubmed Publications
Liver Neoplasms Antibodies	>8 publications with PINX1 and Liver Neoplasms
Adenocarcinoma Antibodies	>7 publications with PINX1 and Adenocarcinoma
Lung Neoplasms Antibodies	>3 publications with PINX1 and Lung Neoplasms
Cardiovascular Diseases Antibodies	>3 publications with PINX1 and Cardiovascular Diseases
Disease Models, Animal Antibodies	>2 publications with PINX1 and Disease Models, Animal
Genital Diseases, Male Antibodies	>2 publications with PINX1 and Genital Diseases, Male
Neoplasm Metastasis Antibodies	>2 publications with PINX1 and Neoplasm Metastasis
Neoplasms, Experimental Antibodies	>2 publications with PINX1 and Neoplasms, Experimental
Uterine Cervical Neoplasms Antibodies	>2 publications with PINX1 and Uterine Cervical Neoplasms
Heart Diseases Antibodies	>2 publications with PINX1 and Heart Diseases

Organs/Tissues associated with anti-PINX1 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>11 publications with PINX1 and Liver
Lymph Antibodies	>7 publications with PINX1 and Lymph
Stomach Antibodies	>6 publications with PINX1 and Stomach
Lymph Node Antibodies	>6 publications with PINX1 and Lymph Node
Brain Antibodies	>5 publications with PINX1 and Brain
Heart Antibodies	>3 publications with PINX1 and Heart
Lung Antibodies	>3 publications with PINX1 and Lung
Embryonic Tissue Antibodies	>3 publications with PINX1 and Embryonic Tissue
Prostate Antibodies	>2 publications with PINX1 and Prostate
Ovary Antibodies	>1 publications with PINX1 and Ovary