SHP2 Antibody – Polyclonal

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

SHP-2: a SH2-containing a ubiquitously expressed tyrosine-specific protein phosphatase. It participates in signaling events downstream of receptors for growth factors, cytokines, hormones, antigens and extracellular matrices in the control of cell growth, differentiation, migration, and death. Activation of SHP-2 and its association with Gab1 is critical for sustained Erk activation downstream of several growth factor receptors and cytokines.

Protein type: Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: cytoplasm; cytosol; mitochondrion; nucleus; protein complex

Molecular Function: 1-phosphatidylinositol-3-kinase activity; D1 dopamine receptor binding; insulin receptor binding; insulin receptor substrate binding; non-membrane spanning protein tyrosine phosphatase activity; peptide hormone receptor binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phospholipase binding; phosphoprotein phosphatase activity; protein binding; protein domain specific binding; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; SH3/SH2 adaptor activity

Biological Process: abortive mitotic cell cycle; activation of MAPK activity; axonogenesis; Bergmann glial cell differentiation; brain development; cerebellar cortex formation; DNA damage checkpoint; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; genitalia development; glucose homeostasis; heart development; homeostasis of number of cells within a tissue; hormone metabolic process; hormone-mediated signaling; inner ear development; integrin-mediated signaling pathway; leukocyte migration; microvillus organization and biogenesis; multicellular organism growth; negative regulation of cell adhesion mediated by integrin; negative regulation of cortisol secretion; negative regulation of growth hormone secretion; negative regulation of insulin secretion; nerve growth factor receptor signaling pathway; organ growth; phosphoinositide phosphorylation; phosphoinositide-mediated signaling; platelet activation; platelet formation; platelet-derived growth factor receptor signaling pathway; positive regulation of hormone secretion; positive regulation of mitotic cell cycle; regulation of cell adhesion mediated by integrin; regulation of multicellular organism growth; regulation of phosphoinositide 3-kinase cascade; regulation of protein complex assembly; regulation of protein export from nucleus; reproductive process in a multicellular organism; T cell costimulation; triacylglycerol metabolic process

Disease: Juvenile Myelomonocytic Leukemia; Leopard Syndrome 1; Metachondromatosis; Noonan Syndrome 1