MEK7 Antibody – Polyclonal

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

MKK7: a dual-specificity protein kinase of the STE7 family. Activates JNK1 and -2 by phosphorylating a Thr and a Tyr residue in the activation loop. Is activated by proinflammatory cytokines and environmental stress. Three alternatively spliced isoforms have been reported.

Protein type: Protein kinase, dual-specificity (non-receptor); Protein kinase, STE; Kinase, protein; EC 2.7.12.2; STE group; STE7 family

Chromosomal Location of Human Ortholog: 19p13.3-p13.2

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: ATP binding; enzyme binding; JUN kinase kinase activity; magnesium ion binding; MAP kinase kinase activity; mitogen-activated protein kinase kinase kinase binding; protein binding; protein C-terminus binding; protein kinase binding; protein phosphatase binding; protein-tyrosine kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: activation of JNK activity; apoptosis; JNK cascade; peptidyl-tyrosine phosphorylation; positive regulation of neuron apoptosis; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; response to heat; response to osmotic stress; response to UV; signal transduction; stress-activated MAPK cascade