PIGR Antibody – Polyclonal

This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]

PIGR: This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

Protein type: Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1q31-q41

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: polymeric immunoglobulin receptor activity

Biological Process: detection of chemical stimulus involved in sensory perception of bitter taste; epidermal growth factor receptor signaling pathway; immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor; receptor clustering; retinal homeostasis

Disease: Iga Nephropathy, Susceptibility To, 1