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TNF Receptor II (TNFRSF1B) Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178152

Tumor necrosis factor receptor 2 (TNFR2) is one of receptors of TNF. TNF has proinflammatory and immunosuppressive properties that may segregate at the level of the 2 TNF receptors (TNFRs), TNFR1 and TNFR2. The genes for TNFR1, a 55-kDa protein, and TNFR2, a… More details

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Product Overview

Online Datasheet in PDF
Product Name
TNF Receptor II (Tnfrsf1b), Polyclonal Antibody
Full Product Name
Anti-TNF Receptor II Antibody
Product Gene Name
anti-Tnfrsf1b antibody
Product Synonym Names
Tumor necrosis factor receptor superfamily member 1B; CD 120b; CD120b; CD120b antigen; Etanercept; p75; p75TNFR; p80 TNF alpha receptor; p80 TNF-alpha receptor; TBP-2; TBP2; TBPII; TNF R II; TNF R2; TNF R75; TNF-R2; TNF-RII; TNFBR; TNFR 2; TNFR-II; TNFR2; TNFR75; TNFR80; TNFRII; TNFRSF 1B; TNFRSF1B; TNR1B; TNR1B_HUMAN; Tumor necrosis factor beta receptor; Tumor necrosis factor binding protein 2; Tumor necrosis factor receptor 2; Tumor necrosis factor receptor superfamily member 1B precursor; Tumor necrosis factor receptor type II; Tumor necrosis factor-binding protein 2; tumor necrosis factor receptor superfamily, member 1B
Clonality
Polyclonal
Isotype
IgG
Species Reactivity
Mouse, Rat
Form/Format
Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen Affinity Purified
Preparation and Storage
At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquoted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
3D Structure
ModBase 3D Structure for P25119
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of mouse TNF Receptor II (296-324aa QRDAKVPHVPDEKSQDAVGLEQQHLLTTA), different from the related human sequence by eleven amino acids, and from the related rat sequence by six amino acids.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-Tnfrsf1b antibody
Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)
Application Notes for anti-Tnfrsf1b antibody
Western Blot:
Concentration: 0.1-0.5 ug/mL
Tested Species: Mouse, Rat

Immunohistochemistry (Paraffin-embedded Section):
Concentration: 0.5-1 ug/mL
Tested Species: Mouse, Rat

Tested Species: In-house tested species with positive results.
Other applications have not been tested.
Optimal dilutions should be determined by end users.

Western Blot (WB) of anti-Tnfrsf1b antibody

Anti- TNF Receptor II Picoband antibody, MBS178152, Western blotting
All lanes: Anti TNF Receptor II (MBS178152) at 0.5ug/ml
Lane 1: Rat Thymus Tissue Lysate at 50ug
Lane 2: Mouse Thymus Tissue Lysate at 50ug
Predicted bind size: 75KD
Observed bind size: 75KD
Anti-TNFRSF1B Polyclonal Antibody – Cat# MBS178152

Immunohistochemistry (IHC) of anti-Tnfrsf1b antibody

Anti- TNF Receptor II Picoband antibody, MBS178152, IHC(P)
IHC(P): Mouse Thymus Tissue
Anti-TNFRSF1B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS178152

Immunohistochemistry (IHC) of anti-Tnfrsf1b antibody

Anti- TNF Receptor II Picoband antibody, MBS178152, IHC(P)
IHC(P): Rat Spleen Tissue
Anti-TNFRSF1B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS178152

Product References and Citations for anti-Tnfrsf1b antibody

1. Milatovich, A.; Song, K.; Heller, R. A.; Francke, U. : Tumor necrosis factor receptor genes, TNFR1 and TNFR2, on human chromosomes 12 and 1. Somat. Cell Molec. Genet. 17: 519-523, 1991. 2. Vielhauer, V.; Stavrakis, G.; Mayadas, T. N. : Renal cell-expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis. J. Clin. Invest. 115: 1199-1209, 2005.

Other Notes

Small volumes of anti-Tnfrsf1b antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tnfrsf1b purchase

MBS178152 is an antibody targeting Tnfrsf1b. Also known as Anti-TNF Receptor II Antibody. Reactive in Mouse, Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for Tnfrsf1b. It may not necessarily be applicable to this product.

NCBI GI #
70778792
NCBI GeneID
21938
NCBI Accession #
NP_035740.2
UniProt Primary Accession #
P25119
UniProt Secondary Accession #
O88734; P97893
UniProt Related Accession #
P25119
GenBank Nucleotide #
NM_011610.3
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 1B
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 1b
NCBI Official Symbol
Tnfrsf1b
NCBI Official Synonym Symbols
p75; TNFBR; Tnfr2; CD120b; TNF-R2; TNFR80; TNFRII; Tnfr-1; TNF-R75; TNF-R-II; TNF-alphaR2; TNFalpha-R2
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 1B
UniProt Synonym Protein Names
Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha receptor; CD_antigen: CD120b
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
Tnfrsf1b
UniProt Synonym Gene Names
Tnfr-2; Tnfr2; TNF-R2; TNF-RII; TNFR-II
UniProt Entry Name
TNR1B_MOUSE
NCBI Protein Information
tumor necrosis factor receptor superfamily member 1B

UniProt Comments for Tnfrsf1b

TNF-R2: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. Binds to TRAF2. Interacts with BMX. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Cellular Component: axon; cell soma; integral to membrane; integral to plasma membrane; lipid raft; membrane; nucleus; perinuclear region of cytoplasm

Molecular Function: protein binding; tumor necrosis factor receptor activity; ubiquitin protein ligase binding

Biological Process: cell proliferation; cell surface receptor linked signal transduction; DNA damage response, signal transduction resulting in induction of apoptosis; immune response; inflammatory response; multicellular organismal development; negative regulation of inflammatory response; positive regulation of MAPKKK cascade; positive regulation of membrane protein ectodomain proteolysis; regulation of apoptosis; regulation of cell proliferation; response to lipopolysaccharide; RNA destabilization
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Research Articles on Tnfrsf1b

1. our findings implicate TNFR2 in supporting myeloid-derived suppressor cells -mediated immune suppression and metastasis in the liver

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Tnfrsf1b antibody

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 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram

Diseases associated with anti-Tnfrsf1b antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >157 publications with Tnfrsf1b and Necrosis
 Inflammation Antibodies  >46 publications with Tnfrsf1b and Inflammation
 Cardiovascular Diseases Antibodies  >19 publications with Tnfrsf1b and Cardiovascular Diseases
 Lung Diseases Antibodies  >13 publications with Tnfrsf1b and Lung Diseases
 Heart Diseases Antibodies  >12 publications with Tnfrsf1b and Heart Diseases
 Hypertension Antibodies  >10 publications with Tnfrsf1b and Hypertension
 Obesity Antibodies  >10 publications with Tnfrsf1b and Obesity
 Kidney Diseases Antibodies  >10 publications with Tnfrsf1b and Kidney Diseases
 Insulin Resistance Antibodies  >9 publications with Tnfrsf1b and Insulin Resistance
 Fractures, Bone Antibodies  >5 publications with Tnfrsf1b and Fractures, Bone

Organs/Tissues associated with anti-Tnfrsf1b antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >80 publications with Tnfrsf1b and Blood
 Bone Antibodies  >15 publications with Tnfrsf1b and Bone
 Kidney Antibodies  >13 publications with Tnfrsf1b and Kidney
 Lung Antibodies  >10 publications with Tnfrsf1b and Lung
 Skin Antibodies  >8 publications with Tnfrsf1b and Skin
 Joint Antibodies  >6 publications with Tnfrsf1b and Joint
 Liver Antibodies  >6 publications with Tnfrsf1b and Liver
 Bone Marrow Antibodies  >6 publications with Tnfrsf1b and Bone Marrow
 Ovary Antibodies  >5 publications with Tnfrsf1b and Ovary
 Connective Tissue Antibodies  >4 publications with Tnfrsf1b and Connective Tissue
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