Anti-CD30 Polyclonal Antibody – Cat# MBS178166

Anti-CD30 Picoband antibody,.jpg
All lanes: Anti-CD30 at 0.5ug/ml
Lane 1: HELA Whole Cell Lysate at 40ug
Lane 2: 293T Whole Cell Lysate at 40ug
Lane 3: JURKAT Whole Cell Lysate at 40ug
Predicted bind size: 67KD
Observed bind size: 67KD

CD30 Antibody – Polyclonal

Name: CD30 Antibody; Polyclonal; Human-Reactive; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS178166
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178166

Description: Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 8(TNFRSF8) detection. Tested with WB in Human.Background: CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD30, Polyclonal Antibody

Full Product Name

Anti-CD30 Antibody

Product Gene Name

anti-CD30 antibody

Product Synonym Names

Tumor necrosis factor receptor superfamily member 8; CD 30; CD153; CD30; CD30 antigen; CD30L receptor; Cytokine receptor CD30; D1S166E; KI 1; Ki 1 antigen; Ki-1 antigen; KI1; Lymphocyte activation antigen CD30; TNFRSF 8; TNFRSF8; TNR8_HUMAN; Tumor Necrosis Factor Receptor Superfamily Member 8; tumor necrosis factor receptor superfamily, member 8

Clonality

Polyclonal

Species Reactivity

Human

Form/Format

Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purity/Purification

Immunogen Affinity Purified

Preparation and Storage

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Molecular Weight

50,935 Da

OMIM

153243

3D Structure

ModBase 3D Structure for P28908

Immunogen

E Coli-derived human CD30 recombinant protein (Position: T322-K595). Human CD30 shares 60% and 57% amino acid (aa) sequences identity with mouse and rat CD30, respectively.

Ig Type

Rabbit IgG

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-CD30 antibody

Western Blot (WB)

Application Notes for anti-CD30 antibody

Western Blot Concentration: 0.1-0.5ug/ml

Product References and Citations for anti-CD30 antibody

1. Fischer, M., Harvima, I. T., Carvalho, R. F. S., Moller, C., Naukkarinen, A., Enblad, G., Nilsson, G. Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion. J. Clin. Invest. 116: 2748-2756, 2006. 2. Gorczyca W, Tsang P, Liu Z, et al. (February 2003). "CD30-positive T-cell lymphomas co-expressing CD15: an immunohistochemical analysis". Int. J. Oncol. 22 (2): 319-24. 3. Teng LH, Lu DH, Xu QZ, Fu YJ, Yang H, He ZL (2005). "[Expression and diagnostic significance of OCT4, CD117 and CD30 in germ cell tumors]". Zhonghua Bing Li Xue Za Zhi (in Chinese) 34 (11): 711-5.

Other Notes

Small volumes of anti-CD30 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD30 purchase

MBS178166 is an antibody targeting CD30. Reactive in Human.

Additional Details

NCBI/Uniprot data below describe general gene information for CD30. It may not necessarily be applicable to this product.

NCBI GI #

597709795

NCBI GeneID

943

NCBI Accession #

NP_001234.3

UniProt Primary Accession #

P28908

UniProt Secondary Accession #

Q6P4D9; B1AN79; B9EGD9; D3YTD8

UniProt Related Accession #

P28908

GenBank Nucleotide #

NM_001243.4

NCBI Official Full Name

tumor necrosis factor receptor superfamily member 8 isoform 1

NCBI Official Synonym Full Names

tumor necrosis factor receptor superfamily member 8

NCBI Official Symbol

TNFRSF8

NCBI Official Synonym Symbols

CD30; Ki-1; D1S166E

UniProt Protein Name

Tumor necrosis factor receptor superfamily member 8

UniProt Synonym Protein Names

CD30L receptor; Ki-1 antigen; Lymphocyte activation antigen CD30; CD_antigen: CD30

Protein Family

CD302 antigen

UniProt Gene Name

TNFRSF8

UniProt Synonym Gene Names

CD30; D1S166E

UniProt Entry Name

TNR8_HUMAN

NCBI Protein Information

tumor necrosis factor receptor superfamily member 8

NCBI Summary for CD30

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

UniProt Comments for CD30

TNFRSF8: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: cytoplasm; integral to plasma membrane

Molecular Function: transmembrane receptor activity; tumor necrosis factor receptor activity

Biological Process: immune response; inflammatory response; multicellular organismal development; negative regulation of cell proliferation; positive regulation of apoptosis; positive regulation of TRAIL biosynthetic process; positive regulation of tumor necrosis factor biosynthetic process; response to lipopolysaccharide; signal transduction; tumor necrosis factor-mediated signaling pathway

Research Articles on CD30

1. Our results demonstrated significantly elevated sCD30 levels in AS patients compared to healthy controls (HCs) with mean values of 32.0 +/- 12.2 and 24.9 +/- 8.0 ng/mL, (P(**) = 0.007), suggesting a p role of sCD30 in the pathogenesis of AS.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD30 antibody

Reference Product	PubMed Publications
CD4 antibody	>415 publications with CD30 and CD4
ALK antibody	>200 publications with CD30 and ALK
CD5 antibody	>105 publications with CD30 and CD5
TNFSF8 antibody	>97 publications with CD30 and TNFSF8
TRAF2 antibody	>36 publications with CD30 and TRAF2
TRAF1 antibody	>27 publications with CD30 and TRAF1
ICAM1 antibody	>23 publications with CD30 and ICAM1
TRAF3 antibody	>13 publications with CD30 and TRAF3
TRAF5 antibody	>10 publications with CD30 and TRAF5
FUT4 antibody	>6 publications with CD30 and FUT4

Pathways associated with anti-CD30 antibody

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
TNF-alpha/NF-kB Signaling Pathway antibodies	TNF-alpha/NF-kB Signaling Pathway Diagram

Diseases associated with anti-CD30 antibody

Disease Name	Pubmed Publications
Hodgkin Disease Antibodies	>601 publications with CD30 and Hodgkin Disease
Necrosis Antibodies	>318 publications with CD30 and Necrosis
Inflammation Antibodies	>96 publications with CD30 and Inflammation
Cell Transformation, Neoplastic Antibodies	>66 publications with CD30 and Cell Transformation, Neoplastic
Fever Antibodies	>64 publications with CD30 and Fever
Hyperplasia Antibodies	>59 publications with CD30 and Hyperplasia
Neoplasm Metastasis Antibodies	>51 publications with CD30 and Neoplasm Metastasis
Disease Models, Animal Antibodies	>47 publications with CD30 and Disease Models, Animal
Liver Diseases Antibodies	>46 publications with CD30 and Liver Diseases
Kidney Diseases Antibodies	>29 publications with CD30 and Kidney Diseases

Organs/Tissues associated with anti-CD30 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1216 publications with CD30 and Blood
Lymph Node Antibodies	>360 publications with CD30 and Lymph Node
Lung Antibodies	>79 publications with CD30 and Lung
Intestine Antibodies	>28 publications with CD30 and Intestine
Embryonic Tissue Antibodies	>24 publications with CD30 and Embryonic Tissue
Testis Antibodies	>23 publications with CD30 and Testis
Uterus Antibodies	>7 publications with CD30 and Uterus
Salivary Gland Antibodies	>2 publications with CD30 and Salivary Gland