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RAB10 Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178168

Description: Rabbit IgG polyclonal antibody for Ras-related protein Rab-10(RAB10) detection. Tested with WB in Human;Mouse;Rat.Background: Ras-related protein Rab-10 is a protein that in humans is encoded by the RAB10 gene. RAB10 belongs to the RAS… More details

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Product Overview

Online Datasheet in PDF
Product Name
RAB10, Polyclonal Antibody
Full Product Name
Anti-RAB10 Antibody
Product Gene Name
anti-RAB10 antibody
Product Synonym Names
Ras-related protein Rab-10; GTP binding protein RAB10; Rab10; RAB10 member RAS oncogene family; RAB10_HUMAN; Ras related GTP binding protein; Ras related GTP binding protein RAB10; Ras-related protein Rab-10; RAB10, member RAS oncogene family
Clonality
Polyclonal
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen Affinity Purified
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
22,541 Da
OMIM
612672
3D Structure
ModBase 3D Structure for P61026
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human RAB10 (153-185aa AKANINIEKAFLTLAEDILRKTPVKEPNSENVD), identical to the related mouse sequence, and different from the related rat sequence by one amino acid.
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-RAB10 antibody
Western Blot (WB)
Application Notes for anti-RAB10 antibody
Western Blot Concentration: 0.1-0.5ug/ml

Western Blot (WB) of anti-RAB10 antibody

Anti- RAB10 Picoband antibody, MBS178168, Western blotting
All lanes: Anti RAB10 (MBS178168) at 0.5ug/ml
Lane 1: Rat Brain Tissue Lysate at 50ug
Lane 2: Mouse Thymus Tissue Lysate at 50ug
Lane 3: Mouse Brain Tissue Lysate at 50ug
Lane 4: HELA Whole Cell Lysate at 40ug
Lane 5: MCF-7 Whole Cell Lysate at 40ug
Lane 6: COLO320 Whole Cell Lysate at 40ug
Predicted bind size: 22KD
Observed bind size: 22KD
Anti-RAB10 Polyclonal Antibody – Cat# MBS178168

Product References and Citations for anti-RAB10 antibody

1. "Entrez Gene: RAB10 RAB10, member RAS oncogene family". 2. Chen YT, Holcomb C, Moore HP (Aug 1993). "Expression and localization of two low molecular weight GTP-binding proteins, Rab8 and Rab10, by epitope tag". Proc Natl Acad Sci U S A 90 (14): 6508-12. 3. He, H., Dai, F., Yu, L., She, X., Zhao, Y., Jiang, J., Chen, X., Zhao, S. Identification and characterization of nine novel human small GTPases showing variable expressions in liver cancer tissues. Gene Expr. 10: 231-242, 2002.

Other Notes

Small volumes of anti-RAB10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RAB10 purchase

MBS178168 is an antibody targeting RAB10. Reactive in Human, Mouse, Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for RAB10. It may not necessarily be applicable to this product.

NCBI GI #
256222019
NCBI GeneID
10890
NCBI Accession #
NP_057215.3
UniProt Primary Accession #
P61026
UniProt Secondary Accession #
O88386; Q6IA52; Q9D7X6; Q9H0T3; D6W538
UniProt Related Accession #
P61026
GenBank Nucleotide #
NM_016131.4
NCBI Official Full Name
ras-related protein Rab-10
NCBI Official Synonym Full Names
RAB10, member RAS oncogene family
NCBI Official Symbol
RAB10
UniProt Protein Name
Ras-related protein Rab-10
Protein Family
Ras-related protein
UniProt Gene Name
RAB10
UniProt Entry Name
RAB10_HUMAN
NCBI Protein Information
ras-related protein Rab-10

NCBI Summary for RAB10

RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009]

UniProt Comments for RAB10

RAB10: a protein of the GTPase superfamily, Rab family. May be involved in vesicular trafficking and neurotransmitter release. Localized to the inner face of the cell membrane by a lipid-anchor.

Protein type: G protein, monomeric, Rab; G protein; G protein, monomeric

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: cytoplasmic vesicle membrane; endoplasmic reticulum membrane; endosome; exocyst; focal adhesion; Golgi apparatus; Golgi membrane; perinuclear region of cytoplasm; phagocytic vesicle membrane; plasma membrane; recycling endosome; recycling endosome membrane; trans-Golgi network

Molecular Function: GDP binding; GTP binding; GTPase activity; myosin V binding; protein binding

Biological Process: antigen processing and presentation; axonogenesis; cellular response to insulin stimulus; endosome transport; establishment of neuroblast polarity; Golgi to plasma membrane protein transport; Golgi to plasma membrane transport; metabolic process; nucleocytoplasmic transport; polarized epithelial cell differentiation; small GTPase mediated signal transduction; vesicle-mediated transport
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Research Articles on RAB10

1. Rab10 is a target of the GTPase-activating protein AS160, which is inhibited after phosphorylation by the protein kinase Akt.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RAB10 antibody

 Reference Product  PubMed Publications
 TBC1D4 antibody  >9 publications with RAB10 and TBC1D4
 TBC1D1 antibody  >2 publications with RAB10 and TBC1D1
 EXOC6 antibody  >1 publications with RAB10 and EXOC6

Pathways associated with anti-RAB10 antibody

 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Translocation Of GLUT4 To The Plasma Membrane Pathway antibodies  Translocation Of GLUT4 To The Plasma Membrane Pathway Diagram
 Vesicle-mediated Transport Pathway antibodies  Vesicle-mediated Transport Pathway Diagram

Diseases associated with anti-RAB10 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with RAB10 and Inflammation
 Carcinoma Antibodies  >1 publications with RAB10 and Carcinoma
 Liver Diseases Antibodies  >1 publications with RAB10 and Liver Diseases
 Liver Neoplasms Antibodies  >1 publications with RAB10 and Liver Neoplasms
 Edema Antibodies  >1 publications with RAB10 and Edema
 Genital Diseases, Male Antibodies  >1 publications with RAB10 and Genital Diseases, Male
 Disease Models, Animal Antibodies  >1 publications with RAB10 and Disease Models, Animal
 Weight Loss Antibodies  >1 publications with RAB10 and Weight Loss
 Fibrosis Antibodies  >1 publications with RAB10 and Fibrosis

Organs/Tissues associated with anti-RAB10 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >13 publications with RAB10 and Muscle
 Brain Antibodies  >10 publications with RAB10 and Brain
 Kidney Antibodies  >5 publications with RAB10 and Kidney
 Liver Antibodies  >4 publications with RAB10 and Liver
 Intestine Antibodies  >4 publications with RAB10 and Intestine
 Eye Antibodies  >2 publications with RAB10 and Eye
 Lung Antibodies  >2 publications with RAB10 and Lung
 Placenta Antibodies  >2 publications with RAB10 and Placenta
 Blood Antibodies  >2 publications with RAB10 and Blood
 Bone Marrow Antibodies  >1 publications with RAB10 and Bone Marrow
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