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TRIB2 Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178169

Description: Rabbit IgG polyclonal antibody for Tribbles homolog 2(TRIB2) detection. Tested with WB, IHC-P in Human;Mouse;Rat.Background: Tribbles homolog 2 is a protein that in humans is encoded by the TRIB2 gene. This gene encodes one of three members of… More details

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Product Overview

Online Datasheet in PDF
Product Name
TRIB2, Polyclonal Antibody
Full Product Name
Anti-TRIB2 Antibody
Product Gene Name
anti-TRIB2 antibody
Product Synonym Names
Tribbles homolog 2; C5FW; FLJ57420; GS3955; Hypothetical protein TRB2; TRB-2; TRB2; TRIB 2; TRIB2; TRIB2_HUMAN; Tribbles homolog 2; tribbles pseudokinase 2
Clonality
Polyclonal
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen Affinity Purified
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
38,801 Da
OMIM
609462
3D Structure
ModBase 3D Structure for Q92519
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human TRIB2 (175-211aa DLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSD), identical to the related mouse sequence.
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-TRIB2 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Application Notes for anti-TRIB2 antibody
Western Blot Concentration: 0.1-0.5ug/ml
Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml

Western Blot (WB) of anti-TRIB2 antibody

Western blot analysis of TRIB2 expression in SW620 whole cell lysates (lane 1). TRIB2 at 39KD was detected using rabbit anti- TRIB2 Antigen Affinity purified polyclonal antibody at0.5 ug/mL. The blot was developed using chemiluminescence (ECL) method.
Anti-TRIB2 Polyclonal Antibody – Cat# MBS178169

Immunohistochemistry (IHC) of anti-TRIB2 antibody

TRIB2 was detected in paraffin-embedded sections of mouse spleen tissues using rabbit anti- TRIB2 Antigen Affinity purified polyclonal antibody at 1ug/mL. The immunohistochemical section was developed using SABC method.
Anti-TRIB2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS178169

Immunohistochemistry (IHC) of anti-TRIB2 antibody

TRIB2 was detected in paraffin-embedded sections of rat spleen tissues using rabbit anti- TRIB2 Antigen Affinity purified polyclonal antibody at 1ug/mL. The immunohistochemical section was developed using SABC method.
Anti-TRIB2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS178169

Immunohistochemistry (IHC) of anti-TRIB2 antibody

TRIB2 was detected in paraffin-embedded sections of human tonsil tissues using rabbit anti- TRIB2 Antigen Affinity purified polyclonal antibody at 1ug/mL. The immunohistochemical section was developed using SABC method.
Anti-TRIB2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS178169

Product References and Citations for anti-TRIB2 antibody

1. "Entrez Gene: TRIB2 tribbles homolog 2 (Drosophila)". 2. Hegedus Z, Czibula A, Kiss-Toth E (Aug 2006). "Tribbles: novel regulators of cell function; evolutionary aspects". Cell Mol Life Sci 63 (14): 1632-41. 3. Keeshan K, He Y, Wouters BJ, Shestova O, Xu L, Sai H, Rodriguez CG, Maillard I, Tobias JW, Valk P, Carroll M, Aster JC, Delwel R, Pear WS (Nov 2006). "Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia". Cancer Cell 10 (5): 401-11.

Other Notes

Small volumes of anti-TRIB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TRIB2 purchase

MBS178169 is an antibody targeting TRIB2. Reactive in Human, Mouse, Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for TRIB2. It may not necessarily be applicable to this product.

NCBI GI #
11056054
NCBI GeneID
28951
NCBI Accession #
NP_067675.1
UniProt Primary Accession #
Q92519
UniProt Secondary Accession #
B2R851; D6W510
UniProt Related Accession #
Q92519
GenBank Nucleotide #
NM_021643.3
NCBI Official Full Name
tribbles homolog 2
NCBI Official Synonym Full Names
tribbles pseudokinase 2
NCBI Official Symbol
TRIB2
NCBI Official Synonym Symbols
C5FW; TRB2; GS3955
UniProt Protein Name
Tribbles homolog 2
Protein Family
Tribbles
UniProt Gene Name
TRIB2
UniProt Synonym Gene Names
TRB-2
UniProt Entry Name
TRIB2_HUMAN
NCBI Protein Information
tribbles homolog 2

NCBI Summary for TRIB2

This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
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UniProt Comments for TRIB2

TRB2: Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.

Protein type: Protein kinase, CAMK; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CAMK group; Trbl family

Chromosomal Location of Human Ortholog: 2p24.3

Cellular Component: cytoplasm; cytoskeleton; nucleus

Molecular Function: mitogen-activated protein kinase kinase binding; nucleotide binding; protein kinase activity; protein kinase inhibitor activity; transcription factor binding; ubiquitin protein ligase binding; ubiquitin-protein ligase regulator activity

Biological Process: negative regulation of fat cell differentiation; negative regulation of interleukin-10 biosynthetic process; negative regulation of protein kinase activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein amino acid phosphorylation; regulation of MAP kinase activity
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Research Articles on TRIB2

1. The results suggest that TRIB2 is a meaningful biomarker reflecting diagnosis and progression of melanoma, as well as predicting clinical response to chemotherapy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TRIB2 antibody

 Reference Product  PubMed Publications
 SMURF1 antibody  >3 publications with TRIB2 and SMURF1

Diseases associated with anti-TRIB2 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >13 publications with TRIB2 and Nervous System Diseases
 Carcinoma Antibodies  >8 publications with TRIB2 and Carcinoma
 Cell Transformation, Neoplastic Antibodies  >7 publications with TRIB2 and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >4 publications with TRIB2 and Disease Models, Animal
 Lung Diseases Antibodies  >4 publications with TRIB2 and Lung Diseases
 Liver Neoplasms Antibodies  >4 publications with TRIB2 and Liver Neoplasms
 Adenocarcinoma Antibodies  >4 publications with TRIB2 and Adenocarcinoma
 Lung Neoplasms Antibodies  >4 publications with TRIB2 and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >4 publications with TRIB2 and Carcinoma, Hepatocellular
 Inflammation Antibodies  >3 publications with TRIB2 and Inflammation

Organs/Tissues associated with anti-TRIB2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >22 publications with TRIB2 and Blood
 Bone Antibodies  >8 publications with TRIB2 and Bone
 Lung Antibodies  >7 publications with TRIB2 and Lung
 Liver Antibodies  >6 publications with TRIB2 and Liver
 Brain Antibodies  >6 publications with TRIB2 and Brain
 Muscle Antibodies  >4 publications with TRIB2 and Muscle
 Heart Antibodies  >4 publications with TRIB2 and Heart
 Skin Antibodies  >4 publications with TRIB2 and Skin
 Eye Antibodies  >3 publications with TRIB2 and Eye
 Prostate Antibodies  >3 publications with TRIB2 and Prostate
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