NMDAR2C Antibody – Polyclonal

This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

NMDAR2C: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2C/GRIN2C subfamily.

Protein type: Channel, calcium; Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17q25.1

Cellular Component: cell junction; integral to plasma membrane; N-methyl-D-aspartate selective glutamate receptor complex; plasma membrane; postsynaptic density; postsynaptic membrane

Molecular Function: cation channel activity; extracellular-glutamate-gated ion channel activity; N-methyl-D-aspartate selective glutamate receptor activity; PDZ domain binding; protein binding; protein N-terminus binding; Ras guanyl-nucleotide exchange factor activity

Biological Process: directional locomotion; glutamate signaling pathway; ionotropic glutamate receptor signaling pathway; MAPKKK cascade; negative regulation of protein catabolic process; neuromuscular process controlling balance; positive regulation of GTPase activity; protein localization; regulation of excitatory postsynaptic membrane potential; response to wounding; synaptic transmission; transport