Anti-SFRP2 Polyclonal Antibody – Cat# MBS178179

Anti- SFRP2 Picoband antibody, MBS178179, Western blotting
All lanes: Anti SFRP2 (MBS178179) at 0.5ug/ml
Lane 1: COLO320 Whole Cell Lysate at 40ug
Lane 2: SW620 Whole Cell Lysate at 40ug
Predicted bind size: 33KD
Observed bind size: 33KD

SFRP2 Antibody – Polyclonal

Name: SFRP2 Antibody; Polyclonal; Human-Reactive; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS178179
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178179

Description: Rabbit IgG polyclonal antibody for Secreted frizzled-related protein 2(SFRP2) detection. Tested with WB, ELISA in Human.Background: SFRP2 is also known as FRP-2, SARP1 or SDF-5. It is Expressed in adipose tissue, heart, brain, skeletal muscle,… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SFRP2, Polyclonal Antibody

Full Product Name

Anti-SFRP2 Antibody

Product Gene Name

anti-SFRP2 antibody

Product Synonym Names

Secreted frizzled-related protein 2; AI851596; Frizzled related protein 2; FRP 2; FRP-2; FRP2; MGC128911; MGC153618; MGC53344; SARP 1; SARP-1; SARP1; SDF 5; SDF5; Secreted apoptosis related protein 1; Secreted apoptosis-related protein 1; Secreted frizzled related protein 2; Secreted frizzled-related protein 2; sFRP 2; sFRP-2; SFRP2; Sfrp2 protein; SFRP2_HUMAN; secreted frizzled-related protein 2

Clonality

Polyclonal

Species Reactivity

Human

Form/Format

Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purity/Purification

Immunogen Affinity Purified

Preparation and Storage

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Molecular Weight

33,490 Da

OMIM

604157

3D Structure

ModBase 3D Structure for Q96HF1

Immunogen

E Coli-derived human SFRP2 recombinant protein (Position: L104-C295). Human SFRP2 shares 99% amino acid (aa) sequence identity with mouse SFRP2.

Ig Type

Rabbit IgG

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-SFRP2 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-SFRP2 antibody

ELISA Concentration: 0.1-0.5ug/ml
Western Blot Concentration: 0.1-0.5ug/ml

Product References and Citations for anti-SFRP2 antibody

1. Hao XW, et al. Epigenetic inactivation of secreted frizzled-related protein 2 in esophageal squamous cell carcinoma. World J Gastroenterol, 2012 Feb 14. 2. O'Hurley G, et al. The role of secreted frizzled-related protein 2 expression in prostate cancer. Histopathology, 2011 Dec. 3. Sui C, et al. Variation risks of SFRP2 hypermethylation between precancerous disease and colorectal cancer. Tumour Biol, 2014 Oct.

Other Notes

Small volumes of anti-SFRP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SFRP2 purchase

MBS178179 is an antibody targeting SFRP2. Reactive in Human.

Additional Details

NCBI/Uniprot data below describe general gene information for SFRP2. It may not necessarily be applicable to this product.

NCBI GI #

48475052

NCBI GeneID

6423

NCBI Accession #

NP_003004.1

UniProt Primary Accession #

Q96HF1

UniProt Secondary Accession #

O14778; Q9HAP5; B3KQR2

UniProt Related Accession #

Q96HF1

GenBank Nucleotide #

NM_003013.2

NCBI Official Full Name

secreted frizzled-related protein 2

NCBI Official Synonym Full Names

secreted frizzled related protein 2

NCBI Official Symbol

SFRP2

NCBI Official Synonym Symbols

FRP-2; SARP1; SDF-5

UniProt Protein Name

Secreted frizzled-related protein 2

UniProt Synonym Protein Names

Secreted apoptosis-related protein 1; SARP-1

Protein Family

Secreted frizzled-related protein

UniProt Gene Name

SFRP2

UniProt Synonym Gene Names

FRP2; SARP1; FRP-2; sFRP-2; SARP-1

UniProt Entry Name

SFRP2_HUMAN

NCBI Protein Information

secreted frizzled-related protein 2

NCBI Summary for SFRP2

This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008]

UniProt Comments for SFRP2

SFRP2: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis. Belongs to the secreted frizzled-related protein (sFRP) family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q31.3

Cellular Component: extracellular matrix; extracellular space; integral to membrane

Molecular Function: fibronectin binding; G-protein coupled receptor activity; integrin binding; receptor agonist activity; Wnt receptor activity; Wnt-protein binding

Biological Process: cell-cell signaling; cellular response to extracellular stimulus; chondrocyte development; collagen fibril organization; convergent extension involved in axis elongation; digestive tract morphogenesis; embryonic digit morphogenesis; G-protein coupled receptor protein signaling pathway; male gonad development; negative regulation of BMP signaling pathway; negative regulation of caspase activity; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of JNK activity; negative regulation of mesodermal cell fate specification; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of transcription, DNA-dependent; negative regulation of Wnt receptor signaling pathway; patterning of blood vessels; positive regulation of angiogenesis; positive regulation of apoptosis; positive regulation of cell adhesion mediated by integrin; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of fat cell differentiation; positive regulation of osteoblast differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; response to drug; response to nutrient

Research Articles on SFRP2

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SFRP2 antibody

Products by Pathway	Pathway Diagram
Negative Regulation Of TCF-dependent Signaling By WNT Ligand Antagonists Pathway antibodies	Negative Regulation Of TCF-dependent Signaling By WNT Ligand Antagonists Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By Wnt Pathway antibodies	Signaling By Wnt Pathway Diagram
TCF Dependent Signaling In Response To WNT Pathway antibodies	TCF Dependent Signaling In Response To WNT Pathway Diagram
Wnt Signaling Pathway NetPath antibodies	Wnt Signaling Pathway NetPath Diagram
Wnt Signaling Pathway antibodies	Wnt Signaling Pathway Diagram
Wnt Signaling Pathway antibodies	Wnt Signaling Pathway Diagram

Diseases associated with anti-SFRP2 antibody

Disease Name	Pubmed Publications
Carcinoma Antibodies	>70 publications with SFRP2 and Carcinoma
Colorectal Neoplasms Antibodies	>49 publications with SFRP2 and Colorectal Neoplasms
Adenocarcinoma Antibodies	>25 publications with SFRP2 and Adenocarcinoma
Carcinoma, Squamous Cell Antibodies	>20 publications with SFRP2 and Carcinoma, Squamous Cell
Breast Neoplasms Antibodies	>20 publications with SFRP2 and Breast Neoplasms
Fibrosis Antibodies	>19 publications with SFRP2 and Fibrosis
Immune System Diseases Antibodies	>16 publications with SFRP2 and Immune System Diseases
Disease Models, Animal Antibodies	>12 publications with SFRP2 and Disease Models, Animal
Inflammation Antibodies	>11 publications with SFRP2 and Inflammation
Cell Transformation, Neoplastic Antibodies	>11 publications with SFRP2 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-SFRP2 antibody

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>58 publications with SFRP2 and Eye
Bone Antibodies	>58 publications with SFRP2 and Bone
Muscle Antibodies	>40 publications with SFRP2 and Muscle
Embryonic Tissue Antibodies	>33 publications with SFRP2 and Embryonic Tissue
Connective Tissue Antibodies	>22 publications with SFRP2 and Connective Tissue
Heart Antibodies	>19 publications with SFRP2 and Heart
Intestine Antibodies	>16 publications with SFRP2 and Intestine
Brain Antibodies	>16 publications with SFRP2 and Brain
Skin Antibodies	>14 publications with SFRP2 and Skin
Kidney Antibodies	>13 publications with SFRP2 and Kidney