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CD63 Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178192

Description: Rabbit IgG polyclonal antibody for CD63 antigen(CD63) detection. Tested with WB, IHC-P in Human.Background: CD63 antigen is a protein that in humans is encoded by the CD63 gene. The protein encoded by this gene is a member of the transmembrane 4… More details

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Product Overview

Online Datasheet in PDF
Product Name
CD63, Polyclonal Antibody
Full Product Name
Anti-CD63 Antibody
Product Gene Name
anti-CD63 antibody
Product Synonym Names
CD63 antigen; Lysosomal associated membrane protein 3; CD 63; CD63; CD63 antigen (melanoma 1 antigen); CD63 antigen; CD63 antigen melanoma 1 antigen; CD63 molecule; CD63_HUMAN; gp55; granulophysin; LAMP 3; LAMP-3; LAMP3; LIMP; Lysosomal-associated membrane protein 3; lysosome associated membrane glycoprotein 3; Mast cell antigen AD1; ME491; melanoma 1 antigen; Melanoma associated antigen ME491; Melanoma associated antigen MLA1; Melanoma-associated antigen ME491; MGC72893; MLA 1; MLA1; NGA; ocular melanoma associated antigen; Ocular melanoma-associated antigen; OMA81H; PTLGP40; Tetraspanin 30; Tetraspanin-30; Tspan 30; Tspan-30; TSPAN30; CD63 molecule
Clonality
Polyclonal
Species Reactivity
Human
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen Affinity Purified
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
17,271 Da
OMIM
155740
3D Structure
ModBase 3D Structure for P08962
Immunogen
E Coli-derived human CD63 recombinant protein (Position: E97-M238). Human CD63 shares 74% and 73% amino acid (aa) sequence identity with mouse and rat CD63, respectively.
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-CD63 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Application Notes for anti-CD63 antibody
Western Blot Concentration: 0.1-0.5ug/ml
Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml

Western Blot (WB) of anti-CD63 antibody

Anti- CD63 Picoband antibody, MBS178192, Western blotting
All lanes: Anti CD63 (MBS178192) at 0.5ug/ml
WB: Recombinant Human CD63 Protein 0.5ng
Predicted bind size: 26KD
Observed bind size: 26KD
Anti-CD63 Polyclonal Antibody – Cat# MBS178192

Western Blot (WB) of anti-CD63 antibody

Anti- CD63 Picoband antibody, MBS178192, Western blotting
All lanes: Anti CD63 (MBS178192) at 0.5ug/ml
WB: HELA Whole Cell Lysate at 40ug
Predicted bind size: 26KD
Observed bind size: 35KD
Anti-CD63 Polyclonal Antibody, Western Blot (WB) – Cat# MBS178192

Immunohistochemistry (IHC) of anti-CD63 antibody

Anti- CD63 Picoband antibody, MBS178192, IHC(P)
IHC(P): Human Intestinal Cancer Tissue
Anti-CD63 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS178192

Product References and Citations for anti-CD63 antibody

1. "Entrez Gene: CD63 CD63 molecule" 2. Gwynn, B., Eicher, E. M., Peters, L. L. Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals two distinct loci in the mouse genome. Genomics 35: 389-391, 1996.

Other Notes

Small volumes of anti-CD63 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD63 purchase

MBS178192 is an antibody targeting CD63. Reactive in Human.

Additional Details

NCBI/Uniprot data below describe general gene information for CD63. It may not necessarily be applicable to this product.

NCBI GI #
383872447
NCBI GeneID
967
NCBI Accession #
NP_001244318.1
UniProt Primary Accession #
P08962
UniProt Secondary Accession #
Q5TZP3; Q8N6Z9; Q9UCG6; F8VZE2
UniProt Related Accession #
P08962
GenBank Nucleotide #
NM_001257389.1
NCBI Official Full Name
CD63 antigen isoform A
NCBI Official Synonym Full Names
CD63 molecule
NCBI Official Symbol
CD63
NCBI Official Synonym Symbols
MLA1; ME491; LAMP-3; OMA81H; TSPAN30
UniProt Protein Name
CD63 antigen
UniProt Synonym Protein Names
Granulophysin; Lysosomal-associated membrane protein 3; LAMP-3; Melanoma-associated antigen ME491; OMA81H; Ocular melanoma-associated antigen; Tetraspanin-30; Tspan-30; CD_antigen: CD63
Protein Family
CD63 antigen
UniProt Gene Name
CD63
UniProt Synonym Gene Names
MLA1; TSPAN30; LAMP-3; Tspan-30
UniProt Entry Name
CD63_HUMAN
NCBI Protein Information
CD63 antigen

NCBI Summary for CD63

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]
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UniProt Comments for CD63

CD63: This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation. Belongs to the tetraspanin (TM4SF) family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12q12-q13

Cellular Component: cell surface; endosome membrane; extracellular space; integral to plasma membrane; intrinsic to plasma membrane; late endosome membrane; lysosomal membrane; melanosome; plasma membrane; platelet dense granule membrane; protein complex

Molecular Function: protein binding; protein complex binding

Biological Process: cell migration; cell-matrix adhesion; epithelial cell differentiation; pigment granule maturation; platelet degranulation; positive regulation of cell adhesion; positive regulation of receptor internalization; protein transport
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Research Articles on CD63

1. CD163(+) TAMs in oral premalignant lesions coexpress CD163 and STAT1, suggesting that the TAMs in oral premalignant lesions possess an M1 phenotype in a Th1-dominated micromilieu.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD63 antibody

 Reference Product  PubMed Publications
 LAMP1 antibody  >38 publications with CD63 and LAMP1
 SRC antibody  >19 publications with CD63 and SRC
 TIMP1 antibody  >13 publications with CD63 and TIMP1
 LAMP2 antibody  >11 publications with CD63 and LAMP2
 NPY antibody  >3 publications with CD63 and NPY
 UBC antibody  >3 publications with CD63 and UBC
 PTK2 antibody  >1 publications with CD63 and PTK2
 SYT7 antibody  >1 publications with CD63 and SYT7
 ITGB1 antibody  >1 publications with CD63 and ITGB1

Pathways associated with anti-CD63 antibody

 Products by Pathway  Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram

Diseases associated with anti-CD63 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >166 publications with CD63 and Cardiovascular Diseases
 Inflammation Antibodies  >138 publications with CD63 and Inflammation
 Carcinoma Antibodies  >63 publications with CD63 and Carcinoma
 Heart Diseases Antibodies  >53 publications with CD63 and Heart Diseases
 Necrosis Antibodies  >45 publications with CD63 and Necrosis
 Breast Neoplasms Antibodies  >29 publications with CD63 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >28 publications with CD63 and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >27 publications with CD63 and Disease Models, Animal
 Kidney Diseases Antibodies  >26 publications with CD63 and Kidney Diseases
 Lung Neoplasms Antibodies  >25 publications with CD63 and Lung Neoplasms

Organs/Tissues associated with anti-CD63 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1048 publications with CD63 and Blood
 Skin Antibodies  >183 publications with CD63 and Skin
 Vascular Antibodies  >135 publications with CD63 and Vascular
 Lung Antibodies  >77 publications with CD63 and Lung
 Bone Antibodies  >75 publications with CD63 and Bone
 Bone Marrow Antibodies  >59 publications with CD63 and Bone Marrow
 Kidney Antibodies  >55 publications with CD63 and Kidney
 Heart Antibodies  >51 publications with CD63 and Heart
 Brain Antibodies  >47 publications with CD63 and Brain
 Muscle Antibodies  >45 publications with CD63 and Muscle
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