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SFRS3 Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178194

Description: Rabbit IgG polyclonal antibody for Serine/arginine-rich splicing factor 3(SRSF3) detection. Tested with WB in Human;Mouse;Rat.Background: Splicing factor, arginine/serine-rich 3, also known as SRSF3, is a protein that in humans is encoded by the… More details

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Product Overview

Online Datasheet in PDF
Product Name
SFRS3, Polyclonal Antibody
Full Product Name
Anti-SFRS3 Antibody
Product Gene Name
anti-SFRS3 antibody
Product Synonym Names
Serine/arginine-rich splicing factor 3; arginine/serine-rich 3; Pre mRNA splicing factor SRP20; Pre-mRNA-splicing factor SRP20; Serine/arginine-rich splicing factor 3; Splicing factor; Splicing factor arginine/serine rich 20 kD; Splicing factor arginine/ serine rich 3; SRp20; SRSF3; SRSF3_HUMAN; X16; serine/arginine-rich splicing factor 3
Clonality
Polyclonal
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen Affinity Purified
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
14,203 Da
OMIM
603364
3D Structure
ModBase 3D Structure for P84103
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human SFRS3 (1-29aa MHRDSCPLDCKVYVGNLGNNGNKTELERA), identical to the related mouse and rat sequences.
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-SFRS3 antibody
Western Blot (WB)
Application Notes for anti-SFRS3 antibody
Western Blot Concentration: 0.1-0.5ug/ml

Western Blot (WB) of anti-SFRS3 antibody

Anti- SFRS3 Picoband antibody, MBS178194, Western blotting
All lanes: Anti SFRS3 (MBS178194) at 0.5ug/ml
Lane 1: Rat Brain Tissue Lysate at 50ug
Lane 2: Mouse Brain Tissue Lysate at 50ug
Lane 3: HELA Whole Cell Lysate at 40ug
Predicted bind size: 19KD
Observed bind size: 19KD
Anti-SFRS3 Polyclonal Antibody – Cat# MBS178194

Product References and Citations for anti-SFRS3 antibody

1. "Entrez Gene: SFRS3 splicing factor, arginine/serine-rich 3". 2. Zahler AM, Lane WS, Stolk JA, Roth MB (Jun 1992). "SR proteins: a conserved family of pre-mRNA splicing factors". Genes Dev 6 (5): 837-47.

Other Notes

Small volumes of anti-SFRS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SFRS3 purchase

MBS178194 is an antibody targeting SFRS3. Reactive in Human, Mouse, Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for SFRS3. It may not necessarily be applicable to this product.

NCBI GI #
4506901
NCBI GeneID
6428
NCBI Accession #
NP_003008.1
UniProt Primary Accession #
P84103
UniProt Secondary Accession #
O08831; P23152; Q5R3K0; B4E241
UniProt Related Accession #
P84103
GenBank Nucleotide #
NM_003017.4
NCBI Official Full Name
serine/arginine-rich splicing factor 3
NCBI Official Synonym Full Names
serine/arginine-rich splicing factor 3
NCBI Official Symbol
SRSF3
NCBI Official Synonym Symbols
SFRS3; SRp20
UniProt Protein Name
Serine/arginine-rich splicing factor 3
UniProt Synonym Protein Names
Pre-mRNA-splicing factor SRP20; Splicing factor, arginine/serine-rich 3
UniProt Gene Name
SRSF3
UniProt Synonym Gene Names
SFRS3; SRP20
UniProt Entry Name
SRSF3_HUMAN
NCBI Protein Information
serine/arginine-rich splicing factor 3

NCBI Summary for SFRS3

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
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UniProt Comments for SFRS3

SFRS3: May be involved in RNA processing in relation with cellular proliferation and/or maturation. Belongs to the splicing factor SR family.

Protein type: RNA processing; RNA-binding; RNA splicing; Spliceosome

Chromosomal Location of Human Ortholog: 6p21

Cellular Component: cytoplasm; nuclear speck; nucleoplasm

Molecular Function: nucleotide binding; phospholipase binding; protein binding; RNA binding

Biological Process: mRNA 3'-end processing; mRNA export from nucleus; nuclear mRNA splicing, via spliceosome; regulation of nuclear mRNA splicing, via spliceosome; RNA export from nucleus; termination of RNA polymerase II transcription
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Research Articles on SFRS3

1. Depletion of two of the most potent inhibitors of SMP2 exon 7 inclusion, SRSF2 or SRSF3, in cell lines derived from SMA patients, increased SMN2 exon 7 inclusion and SMN protein level.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SFRS3 antibody

 Reference Product  PubMed Publications
 SRSF2 antibody  >9 publications with SFRS3 and SRSF2
 NXF1 antibody  >4 publications with SFRS3 and NXF1
 SREK1 antibody  >2 publications with SFRS3 and SREK1
 PCBP2 antibody  >2 publications with SFRS3 and PCBP2

Pathways associated with anti-SFRS3 antibody

 Products by Pathway  Pathway Diagram
 Cleavage Of Growing Transcript In The Termination Region Pathway antibodies  Cleavage Of Growing Transcript In The Termination Region Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies  Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
 RNA Polymerase II Transcription Pathway antibodies  RNA Polymerase II Transcription Pathway Diagram
 RNA Polymerase II Transcription Termination Pathway antibodies  RNA Polymerase II Transcription Termination Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Transport Of Mature Transcript To Cytoplasm Pathway antibodies  Transport Of Mature Transcript To Cytoplasm Pathway Diagram

Diseases associated with anti-SFRS3 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >9 publications with SFRS3 and Nervous System Diseases
 Liver Diseases Antibodies  >6 publications with SFRS3 and Liver Diseases
 Lung Diseases Antibodies  >5 publications with SFRS3 and Lung Diseases
 Liver Neoplasms Antibodies  >5 publications with SFRS3 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >4 publications with SFRS3 and Carcinoma, Hepatocellular
 Brain Diseases Antibodies  >4 publications with SFRS3 and Brain Diseases
 Neoplasms, Experimental Antibodies  >3 publications with SFRS3 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >2 publications with SFRS3 and Disease Models, Animal
 Heart Diseases Antibodies  >2 publications with SFRS3 and Heart Diseases
 Liver Neoplasms, Experimental Antibodies  >2 publications with SFRS3 and Liver Neoplasms, Experimental

Organs/Tissues associated with anti-SFRS3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with SFRS3 and Blood
 Liver Antibodies  >11 publications with SFRS3 and Liver
 Nerve Antibodies  >7 publications with SFRS3 and Nerve
 Brain Antibodies  >6 publications with SFRS3 and Brain
 Lung Antibodies  >4 publications with SFRS3 and Lung
 Heart Antibodies  >2 publications with SFRS3 and Heart
 Mammary Gland Antibodies  >2 publications with SFRS3 and Mammary Gland
 Kidney Antibodies  >2 publications with SFRS3 and Kidney
 Vascular Antibodies  >2 publications with SFRS3 and Vascular
 Stomach Antibodies  >1 publications with SFRS3 and Stomach
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