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SFRP4 Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178196

Description: Rabbit IgG polyclonal antibody for Secreted frizzled-related protein 4(SFRP4) detection. Tested with WB, IHC-P, ELISA in Human.Background: Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SFRP4, Polyclonal Antibody
Full Product Name
Anti-SFRP4 Antibody
Product Gene Name
anti-SFRP4 antibody
Product Synonym Names
Secreted frizzled-related protein 4; Frizzled protein; Frizzled protein human endometrium; FRP 4; FRP4; FrpHE; human endometrium; Secreted frizzled-related protein 4; sFRP-4; Sfrp4; SFRP4_HUMAN; secreted frizzled-related protein 4
Clonality
Polyclonal
Species Reactivity
Human
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen Affinity Purified
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
39,827 Da
OMIM
606570
3D Structure
ModBase 3D Structure for Q6FHJ7
Immunogen
E Coli-derived human SFRP4 recombinant protein (Position: A22-K303). Human SFRP4 shares 96.8% and 96.1% amino acid (aa) sequence identity with mouse and rat SFRP4, respectively.
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-SFRP4 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, ELISA (EIA)
Application Notes for anti-SFRP4 antibody
ELISA Concentration: 0.1-0.5ug/ml
Western Blot Concentration: 0.1-0.5ug/ml
Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml

Western Blot (WB) of anti-SFRP4 antibody

Western blot analysis of SFRP4 expression in A549 whole cell lysates (lane 1) and SW620 whole cell lysates (lane 2). SFRP4 at 49KD was detected using rabbit anti- SFRP4 Antigen Affinity purified polyclonal antibody at0.5 ug/mL. The blot was developed using chemiluminescence (ECL) method.
Anti-SFRP4 Polyclonal Antibody – Cat# MBS178196

Immunohistochemistry (IHC) of anti-SFRP4 antibody

SFRP4 was detected in paraffin-embedded sections of human endometrial carcinoma tissues using rabbit anti SFRP4 Antigen Affinity purified polyclonal antibody at 1ug/mL. The immunohistochemical section was developed using SABC method.
Anti-SFRP4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS178196

Product References and Citations for anti-SFRP4 antibody

1. "Entrez Gene: SFRP4 secreted frizzled-related protein 4". 2. Horvath LG, Lelliott JE, Kench JG et al. (2007). "Secreted frizzled-related protein 4 inhibits proliferation and metastatic potential in prostate cancer.". Prostate 67 (10): 1081-90.

Other Notes

Small volumes of anti-SFRP4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SFRP4 purchase

MBS178196 is an antibody targeting SFRP4. Reactive in Human.

Additional Details

NCBI/Uniprot data below describe general gene information for SFRP4. It may not necessarily be applicable to this product.

NCBI GI #
170784838
NCBI GeneID
6424
NCBI Accession #
NP_003005.2
UniProt Primary Accession #
Q6FHJ7
UniProt Secondary Accession #
O14877; Q05BG7; Q1ZYW2; Q4G124; Q6FHM0; Q6PD64; B4DYC1
UniProt Related Accession #
Q6FHJ7
GenBank Nucleotide #
NM_003014.3
NCBI Official Full Name
secreted frizzled-related protein 4
NCBI Official Synonym Full Names
secreted frizzled related protein 4
NCBI Official Symbol
SFRP4
NCBI Official Synonym Symbols
FRP-4; FRPHE; sFRP-4
UniProt Protein Name
Secreted frizzled-related protein 4
UniProt Synonym Protein Names
Frizzled protein, human endometrium; FrpHE
Protein Family
Secreted frizzled-related protein
UniProt Gene Name
SFRP4
UniProt Synonym Gene Names
FRPHE; sFRP-4; FrpHE
UniProt Entry Name
SFRP4_HUMAN
NCBI Protein Information
secreted frizzled-related protein 4

NCBI Summary for SFRP4

Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]
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UniProt Comments for SFRP4

SFRP4: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. Belongs to the secreted frizzled-related protein (sFRP) family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7p14.1

Cellular Component: cell surface; cytoplasm; extracellular space; integral to membrane; nucleus

Molecular Function: G-protein coupled receptor activity; protein binding; Wnt receptor activity; Wnt-protein binding

Biological Process: cell differentiation; G-protein coupled receptor protein signaling pathway; multicellular organismal development; negative regulation of cell proliferation; negative regulation of transcription factor activity; negative regulation of Wnt receptor signaling pathway; phosphate ion homeostasis; positive regulation of apoptosis; positive regulation of epidermal cell differentiation; positive regulation of receptor internalization; response to hormone stimulus
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Research Articles on SFRP4

1. sFRP4 expression is inversely related to the aggressiveness of pituitary adenomas, and acts as a tumor suppressor.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SFRP4 antibody

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram

Diseases associated with anti-SFRP4 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >24 publications with SFRP4 and Adenocarcinoma
 Kidney Diseases Antibodies  >14 publications with SFRP4 and Kidney Diseases
 Colorectal Neoplasms Antibodies  >14 publications with SFRP4 and Colorectal Neoplasms
 Inflammation Antibodies  >10 publications with SFRP4 and Inflammation
 Ovarian Diseases Antibodies  >10 publications with SFRP4 and Ovarian Diseases
 Cell Transformation, Neoplastic Antibodies  >10 publications with SFRP4 and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >9 publications with SFRP4 and Breast Neoplasms
 Ovarian Neoplasms Antibodies  >9 publications with SFRP4 and Ovarian Neoplasms
 Neoplasms, Experimental Antibodies  >8 publications with SFRP4 and Neoplasms, Experimental
 Respiratory Tract Diseases Antibodies  >8 publications with SFRP4 and Respiratory Tract Diseases

Organs/Tissues associated with anti-SFRP4 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >52 publications with SFRP4 and Bone
 Kidney Antibodies  >22 publications with SFRP4 and Kidney
 Eye Antibodies  >22 publications with SFRP4 and Eye
 Connective Tissue Antibodies  >19 publications with SFRP4 and Connective Tissue
 Ovary Antibodies  >13 publications with SFRP4 and Ovary
 Uterus Antibodies  >12 publications with SFRP4 and Uterus
 Liver Antibodies  >11 publications with SFRP4 and Liver
 Muscle Antibodies  >11 publications with SFRP4 and Muscle
 Brain Antibodies  >9 publications with SFRP4 and Brain
 Lung Antibodies  >9 publications with SFRP4 and Lung
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