MMP9 Antibody – Polyclonal

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that degrades collagens of type IV, V and XI, and elastin. Mice lacking the encoded protein exhibit an abnormal pattern of skeletal growth plate vascularization and ossification, reduced keratinocyte hyperproliferation at all neoplastic stages, a decreased incidence of invasive tumors, and resistance to experimental autoimmune encephalomyelitis. [provided by RefSeq, Feb 2016]

MMP9: May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1. Activated by 4-aminophenylmercuric acetate and phorbol ester. Up-regulated by ARHGEF4, SPATA13 and APC via the JNK signaling pathway in colorectal tumor cells. Produced by normal alveolar macrophages and granulocytes. Inhibited by histatin-3 1/24 (histatin-5). Inhibited by ECM1. Belongs to the peptidase M10A family.

Protein type: Secreted; EC 3.4.24.35; Motility/polarity/chemotaxis; Secreted, signal peptide; Protease

Cellular Component: extracellular matrix; extracellular region; extracellular space; protein complex; proteinaceous extracellular matrix

Molecular Function: endopeptidase activity; fibronectin binding; hydrolase activity; identical protein binding; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protein complex binding; serine-type endopeptidase activity; zinc ion binding

Biological Process: collagen catabolic process; embryo implantation; extracellular matrix organization and biogenesis; heart development; leukocyte migration; negative regulation of apoptosis; negative regulation of fibroblast proliferation; ossification; positive regulation of angiogenesis; positive regulation of apoptosis; positive regulation of DNA binding; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of keratinocyte migration; positive regulation of leukocyte migration; positive regulation of protein amino acid phosphorylation; positive regulation of synaptic plasticity; protein oligomerization; proteolysis; response to drug; response to oxidative stress; skeletal development; tissue remodeling; transformation of host cell by virus