Anti-FRZB Polyclonal Antibody – Cat# MBS178292

Anti- FRZB Picoband antibody, MBS178292, Western blotting
All lanes: Anti FRZB (MBS178292) at 0.5ug/ml
Lane 1: PANC Whole Cell Lysate at 40ug
Lane 2: U87 Whole Cell Lysate at 40ug
Predicted bind size: 36KD
Observed bind size: 36KD

FRZB Antibody – Polyclonal

Name: FRZB Antibody; Polyclonal; Human-Reactive; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS178292
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178292

Description: Rabbit IgG polyclonal antibody for Secreted frizzled-related protein 3(FRZB) detection. Tested with WB, ELISA in Human.Background: FRZB is also known as FRE or OS1. The protein encoded by this gene is a secreted protein that is involved in the… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FRZB, Polyclonal Antibody

Full Product Name

Anti-FRZB Antibody

Product Gene Name

anti-FRZB antibody

Product Synonym Names

Secreted frizzled-related protein 3; FIZ; FRE; Frezzled; Fritz; Frizzled-related protein 1; FRP; FrzB 1; FRZB; FRZB1; OTTMUSP00000014350; RP23-33L19.1; Secreted frizzled related protein 3 [Precursor]; Secreted frizzled related sequence protein 3; sFRP 3; SFRP; frizzled-related protein

Clonality

Polyclonal

Species Reactivity

Human

Form/Format

Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purity/Purification

Immunogen Affinity Purified

Preparation and Storage

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Molecular Weight

36,254 Da

OMIM

165720

3D Structure

ModBase 3D Structure for Q92765

Immunogen

E Coli-derived human FRZB recombinant protein (Position: E176-N325). Human FRZB shares 90% amino acid (aa) sequence identity with mouse FRZB.

Ig Type

Rabbit IgG

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-FRZB antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-FRZB antibody

ELISA Concentration: 0.1-0.5ug/ml
Western Blot Concentration: 0.1-0.5ug/ml

Product References and Citations for anti-FRZB antibody

1. Baker-Lepain JC, et al. Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis. Arthritis Rheum, 2012 May. 2. Qin S, et al. FRZB knockdown upregulates beta-catenin activity and enhances cell aggressiveness in gastric cancer. Oncol Rep, 2014 May. 3. Wasmann RA, et al. Novel membrane frizzled-related protein gene mutation as cause of posterior microphthalmia resulting in high hyperopia with macular folds. Acta Ophthalmol, 2014 May.

Other Notes

Small volumes of anti-FRZB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FRZB purchase

MBS178292 is an antibody targeting FRZB. Reactive in Human.

Additional Details

NCBI/Uniprot data below describe general gene information for FRZB. It may not necessarily be applicable to this product.

NCBI GI #

38455388

NCBI GeneID

2487

NCBI Accession #

NP_001454.2

UniProt Primary Accession #

Q92765

UniProt Secondary Accession #

O00181; Q99686

UniProt Related Accession #

Q92765

GenBank Nucleotide #

NM_001463.3

NCBI Official Full Name

secreted frizzled-related protein 3

NCBI Official Synonym Full Names

frizzled-related protein

NCBI Official Symbol

FRZB

NCBI Official Synonym Symbols

FRE; OS1; FZRB; hFIZ; FRITZ; FRP-3; FRZB1; SFRP3; SRFP3; FRZB-1; FRZB-PEN

UniProt Protein Name

Secreted frizzled-related protein 3

UniProt Synonym Protein Names

Frezzled; Fritz; Frizzled-related protein 1; FrzB-1

Protein Family

Frizzy aggregation protein

UniProt Gene Name

FRZB

UniProt Synonym Gene Names

FIZ; FRE; FRP; FRZB1; SFRP3; sFRP-3

UniProt Entry Name

SFRP3_HUMAN

NCBI Protein Information

secreted frizzled-related protein 3

NCBI Summary for FRZB

The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]

UniProt Comments for FRZB

FRZB: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. Defects in FRZB are associated with susceptibility to osteoarthritis type 1(OS1). Osteoarthritis is a degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement. Belongs to the secreted frizzled-related protein (sFRP) family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q32.1

Cellular Component: extracellular space; integral to membrane; membrane

Molecular Function: G-protein coupled receptor activity; Wnt receptor activity; Wnt-protein binding

Biological Process: convergent extension involved in organogenesis; G-protein coupled receptor protein signaling pathway; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of Wnt receptor signaling pathway; neural crest cell differentiation; positive regulation of apoptosis; positive regulation of fat cell differentiation; skeletal development

Disease: Osteoarthritis Susceptibility 1

Research Articles on FRZB

1. Intermediate levels of sFRP3 were a predictor of all-cause mortality and re-hospitalization in acute coronary syndromes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FRZB antibody

Reference Product	PubMed Publications
WNT5A antibody	>16 publications with FRZB and WNT5A
WNT8A antibody	>9 publications with FRZB and WNT8A
WNT8B antibody	>4 publications with FRZB and WNT8B
MET antibody	>2 publications with FRZB and MET
ANGPT1 antibody	>1 publications with FRZB and ANGPT1
TCF7L2 antibody	>1 publications with FRZB and TCF7L2
MYF5 antibody	>1 publications with FRZB and MYF5
MYOD1 antibody	>1 publications with FRZB and MYOD1

Pathways associated with anti-FRZB antibody

Products by Pathway	Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Endochondral Ossification Pathway antibodies	Endochondral Ossification Pathway Diagram

Diseases associated with anti-FRZB antibody

Disease Name	Pubmed Publications
Osteoarthritis Antibodies	>51 publications with FRZB and Osteoarthritis
Disease Models, Animal Antibodies	>16 publications with FRZB and Disease Models, Animal
Cardiovascular Diseases Antibodies	>14 publications with FRZB and Cardiovascular Diseases
Adenocarcinoma Antibodies	>11 publications with FRZB and Adenocarcinoma
Kidney Diseases Antibodies	>9 publications with FRZB and Kidney Diseases
Lung Neoplasms Antibodies	>8 publications with FRZB and Lung Neoplasms
Breast Neoplasms Antibodies	>7 publications with FRZB and Breast Neoplasms
Inflammation Antibodies	>7 publications with FRZB and Inflammation
Congenital Abnormalities Antibodies	>6 publications with FRZB and Congenital Abnormalities
Necrosis Antibodies	>5 publications with FRZB and Necrosis

Organs/Tissues associated with anti-FRZB antibody

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>93 publications with FRZB and Bone
Embryonic Tissue Antibodies	>44 publications with FRZB and Embryonic Tissue
Muscle Antibodies	>29 publications with FRZB and Muscle
Connective Tissue Antibodies	>20 publications with FRZB and Connective Tissue
Eye Antibodies	>17 publications with FRZB and Eye
Brain Antibodies	>17 publications with FRZB and Brain
Liver Antibodies	>15 publications with FRZB and Liver
Bone Marrow Antibodies	>14 publications with FRZB and Bone Marrow
Kidney Antibodies	>14 publications with FRZB and Kidney
Lung Antibodies	>11 publications with FRZB and Lung