KCNA5 Antibody – Polyclonal

Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012]

Kv1.5: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation. Defects in KCNA5 are the cause of familial atrial fibrillation type 7 (ATFB7). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, potassium

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: caveola; cytosol; endoplasmic reticulum; Golgi apparatus; integral to plasma membrane; intracellular canaliculus; lipid raft; perinuclear region of cytoplasm; plasma membrane; voltage-gated potassium channel complex; Z disc

Molecular Function: alpha-actinin binding; delayed rectifier potassium channel activity; outward rectifier potassium channel activity; potassium channel inhibitor activity; protein binding; protein kinase binding; receptor binding

Biological Process: membrane hyperpolarization; negative regulation of potassium ion transport; Notch signaling pathway; potassium ion homeostasis; potassium ion transport; protein homooligomerization; reduction of cytosolic calcium ion concentration; regulation of insulin secretion; regulation of membrane potential; regulation of potassium ion transport; regulation of vasoconstriction; response to hydrogen peroxide; response to hyperoxia; response to hypoxia; response to mechanical stimulus; response to organic substance

Disease: Atrial Fibrillation, Familial, 7