• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Vitronectin (VTN) Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178298

Description: Rabbit IgG polyclonal antibody for Vitronectin(VTN) detection. Tested with WB, IHC-P in Human;Mouse;Rat.Background: Vitronectin, also known as VTN, is a protein that in humans is encoded by the VTN gene. The protein encoded by this gene is a… More details

$210 / 0.01 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Vitronectin (VTN), Polyclonal Antibody
Full Product Name
Anti-Vitronectin Antibody
Product Gene Name
anti-VTN antibody
Product Synonym Names
Vitronectin; Complement S Protein; Epibolin; S Protein; S-protein; Serum Spreading Factor; Serum-spreading factor; Somatomedin B; Somatomedin-B; V75; Vitronectin V10 subunit; Vitronectin V65 subunit; VN; VNT; VTN; VTNC_HUMAN; vitronectin
Clonality
Polyclonal
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen Affinity Purified
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
54,306 Da
OMIM
193190
3D Structure
ModBase 3D Structure for P04004
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Vitronectin (446-472 aa RVNLRTRRVDTVDPPYPRSIAQYWLGC), different from the related mouse sequence by two amino acids.
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-VTN antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Application Notes for anti-VTN antibody
Western Blot Concentration: 0.1-0.5ug/ml
Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml

Western Blot (WB) of anti-VTN antibody

Anti- Vitronectin Picoband antibody, MBS178298, Western blotting
All lanes: Anti Vitronectin (MBS178298) at 0.5ug/ml
Lane 1: Rat Liver Tissue Lysate at 50ug
Lane 2: Rat Lung Tissue Lysate at 50ug
Lane 3: HEPG2 Whole Cell Lysate at 40ug
Lane 4: HELA Whole Cell Lysate at 40ug
Lane 5: HEPA Whole Cell Lysate at 40ug
Predicted bind size: 54KD
Observed bind size: 54KD
Anti-VTN Polyclonal Antibody – Cat# MBS178298

Immunohistochemistry (IHC) of anti-VTN antibody

Anti- Vitronectin Picoband antibody, MBS178298, IHC(P)
IHC(P): Human Lung Cancer Tissue
Anti-VTN Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS178298

Product References and Citations for anti-VTN antibody

1. "Entrez Gene: M Vitronectin". 2. Jenne D, Stanley KK (October 1987). "Nucleotide sequence and organization of the human S-protein gene: repeating peptide motifs in the "pexin" family and a model for their evolution". Biochemistry 26 (21): 6735-42. 3. Preissner KT, Seiffert D (January 1998)."Role of vitronectin and its receptors in haemostasis and vascular remodeling" (– SCHOLAR SEARCH). Thromb. Res. 89(1): 1-21.

Other Notes

Small volumes of anti-VTN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VTN purchase

MBS178298 is an antibody targeting VTN. Also known as Anti-Vitronectin Antibody. Reactive in Human, Mouse, Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for VTN. It may not necessarily be applicable to this product.

NCBI GI #
88853069
NCBI GeneID
7448
NCBI Accession #
NP_000629.3
UniProt Primary Accession #
P04004
UniProt Secondary Accession #
P01141; Q9BSH7; B2R7G0
UniProt Related Accession #
P04004
GenBank Nucleotide #
NM_000638.3
NCBI Official Full Name
vitronectin
NCBI Official Synonym Full Names
vitronectin
NCBI Official Symbol
VTN
NCBI Official Synonym Symbols
VN; V75; VNT
UniProt Protein Name
Vitronectin
UniProt Synonym Protein Names
S-protein; Serum-spreading factor; V75
Protein Family
Vitronectin
UniProt Gene Name
VTN
UniProt Synonym Gene Names
VN
UniProt Entry Name
VTNC_HUMAN
NCBI Protein Information
vitronectin

NCBI Summary for VTN

The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for VTN

VTN: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.

Protein type: Cell adhesion; Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q11

Cellular Component: extracellular matrix; extracellular region; extracellular space; proteinaceous extracellular matrix

Molecular Function: extracellular matrix binding; heparin binding; integrin binding; polysaccharide binding; protein binding; scavenger receptor activity

Biological Process: cell adhesion; cell adhesion mediated by integrin; cell-matrix adhesion; extracellular matrix organization and biogenesis; immune response; negative regulation of blood coagulation; oligodendrocyte differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein binding; positive regulation of receptor-mediated endocytosis; positive regulation of smooth muscle cell migration; positive regulation of vascular endothelial growth factor receptor signaling pathway; receptor-mediated endocytosis; regulation of complement activation
Show more

Research Articles on VTN

1. The VN level may be relevant as a clinical biomarker for adverse cardiovascular outcomes not only in patients with ischemic heart disease undergoing coronary interventions.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-VTN antibody

 Reference Product  PubMed Publications
 PLAUR antibody  >3 publications with VTN and PLAUR
 ITGB3 antibody  >2 publications with VTN and ITGB3
 MMP9 antibody  >1 publications with VTN and MMP9
 SERPINE1 antibody  >1 publications with VTN and SERPINE1

Pathways associated with anti-VTN antibody

 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram

Diseases associated with anti-VTN antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >6 publications with VTN and Cardiovascular Diseases
 Liver Diseases Antibodies  >5 publications with VTN and Liver Diseases
 Liver Neoplasms Antibodies  >4 publications with VTN and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >4 publications with VTN and Carcinoma, Hepatocellular
 Nervous System Diseases Antibodies  >3 publications with VTN and Nervous System Diseases
 Disease Models, Animal Antibodies  >3 publications with VTN and Disease Models, Animal
 Heart Diseases Antibodies  >3 publications with VTN and Heart Diseases
 Fibrosis Antibodies  >3 publications with VTN and Fibrosis
 Lung Injury Antibodies  >2 publications with VTN and Lung Injury
 Kidney Diseases Antibodies  >2 publications with VTN and Kidney Diseases

Organs/Tissues associated with anti-VTN antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >18 publications with VTN and Blood
 Brain Antibodies  >15 publications with VTN and Brain
 Heart Antibodies  >7 publications with VTN and Heart
 Liver Antibodies  >7 publications with VTN and Liver
 Lung Antibodies  >5 publications with VTN and Lung
 Embryonic Tissue Antibodies  >4 publications with VTN and Embryonic Tissue
 Kidney Antibodies  >4 publications with VTN and Kidney
 Pancreas Antibodies  >4 publications with VTN and Pancreas
 Eye Antibodies  >3 publications with VTN and Eye
 Placenta Antibodies  >2 publications with VTN and Placenta
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000