YES1 Antibody – Polyclonal

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

Yes: a proto-oncogenic cytosolic tyrosine kinase of the Src family. Expressed at high levels in adult neurons, spermatozoa, platelets, and epithelial cells.

Protein type: Protein kinase, TK; Kinase, protein; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Oncoprotein; TK group; Src family

Chromosomal Location of Human Ortholog: 18p11.31-p11.21

Cellular Component: actin filament; cytoplasm; cytosol; extrinsic to internal side of plasma membrane; focal adhesion; Golgi apparatus; microtubule organizing center; plasma membrane

Molecular Function: ATP binding; enzyme binding; epidermal growth factor receptor binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity; receptor binding

Biological Process: cell differentiation; ephrin receptor signaling pathway; glucose transport; innate immune response; leukocyte migration; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein modification process; regulation of cell proliferation; regulation of vascular permeability; T cell costimulation; transmembrane receptor protein tyrosine kinase signaling pathway