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IL18 Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178305

Description: Rabbit IgG polyclonal antibody for Interleukin-18(IL18) detection. Tested with WB in Mouse.Background: Interleukin-18, also known as IL18, is a protein which in humans is encoded by the IL18 gene. IL-18 is a cytokine produced by macrophages and… More details

$210 / 0.01 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
IL18, Polyclonal Antibody
Full Product Name
Anti-IL18 Antibody
Product Gene Name
anti-IL18 antibody
Product Synonym Names
Interleukin-18; Iboctadekin; IFN gamma inducing factor; IFN-gamma-inducing factor; IGIF; IL 1 gamma; IL 18; IL 1g; IL-1 gamma; IL-18; IL1 gamma; IL18; IL18 protein; IL18_HUMAN; IL1F4; IL1g; IL1gamma; ILIF4; Interferon gamma inducing factor; Interferon gamma-inducing factor; Interleukin 1 gamma; Interleukin 18; Interleukin-1 gamma; Interleukin-18; Interleukin18; MGC12320; interleukin 18
Clonality
Polyclonal
Species Reactivity
Mouse
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen Affinity Purified
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
3D Structure
ModBase 3D Structure for P70380
Immunogen
E Coli-derived mouse IL18 recombinant protein (Position: N36-S192). Mouse IL18 shares 66% and 91% amino acid (aa) sequence identity with human and rat IL18, respectively.
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-IL18 antibody
Western Blot (WB)
Application Notes for anti-IL18 antibody
Western Blot Concentration: 0.1-0.5ug/ml

WB: The detection limit for IL18 is approximately 0.25ng/lane under reducing conditons.
Tested Species: In-house tested species with positive results.

Other applicatons have not been tested yet.
Optimal dilutions should be determined by end users.

Product References and Citations for anti-IL18 antibody

1. Okamura H, Tsutsi H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, Torigoe K, Okura T, Nukada Y, Hattori K (November 1995). "Cloning of a new cytokine that induces IFN-gamma production by T cells". Nature 378 (6552): 88-91. 2. Nolan KF, Greaves DR, Waldmann H (July 1998). "The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci". Genomics 51 (1): 161-3.. 3. "Entrez Gene: IL18 interleukin 18 (interferon-gamma-inducing factor)". 4. Nolan, K. F., Greaves, D. R., Waldmann, H. The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci. Genomics 51: 161-163, 1998.

Other Notes

Small volumes of anti-IL18 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL18 purchase

MBS178305 is an antibody targeting IL18. Reactive in Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for IL18. It may not necessarily be applicable to this product.

NCBI GI #
6680413
NCBI GeneID
16173
NCBI Accession #
NP_032386.1
UniProt Primary Accession #
P70380
UniProt Related Accession #
P70380
GenBank Nucleotide #
NM_008360.1
NCBI Official Full Name
interleukin-18
NCBI Official Synonym Full Names
interleukin 18
NCBI Official Symbol
Il18
NCBI Official Synonym Symbols
Igif; Il-18
UniProt Protein Name
Interleukin-18
UniProt Synonym Protein Names
Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma
Protein Family
Interleukin
UniProt Gene Name
Il18
UniProt Synonym Gene Names
Igif; IL-18; IFN-gamma-inducing factor; IL-1 gamma
UniProt Entry Name
IL18_MOUSE
NCBI Protein Information
interleukin-18

UniProt Comments for IL18

IL18: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. Belongs to the IL-1 family.

Protein type: Cytokine

Cellular Component: apical plasma membrane; cytoplasm; extracellular region; extracellular space

Molecular Function: cytokine activity

Biological Process: angiogenesis; detection of mechanical stimulus involved in sensory perception of pain; immune response; induction of apoptosis via death domain receptors; inflammatory response; interferon-gamma biosynthetic process; interleukin-13 biosynthetic process; lipopolysaccharide-mediated signaling pathway; MAPKKK cascade; natural killer cell activation; negative regulation of myoblast differentiation; negative regulation of neutrophil apoptosis; negative regulation of peptidyl-tyrosine phosphorylation; positive regulation of activated T cell proliferation; positive regulation of apoptosis; positive regulation of chemokine production; positive regulation of collagen biosynthetic process; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of interferon-gamma production; positive regulation of interleukin-17 production; positive regulation of interleukin-8 production; positive regulation of natural killer cell proliferation; positive regulation of neuron apoptosis; positive regulation of NF-kappaB import into nucleus; positive regulation of NK T cell proliferation; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of superoxide release; positive regulation of tumor necrosis factor production; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of vascular permeability; regulation of cell adhesion; response to hypoxia; sleep; T-helper 1 type immune response
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Research Articles on IL18

1. These results uncover the direct role of IL-18 in promoting goblet cell dysfunction during colitis, leading to breakdown of the mucosal barrier.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL18 antibody

 Reference Product  PubMed Publications
 Casp1 antibody  >658 publications with IL18 and Casp1
 Il18r1 antibody  >235 publications with IL18 and Il18r1
 Il1b antibody  >89 publications with IL18 and Il1b
 Il18rap antibody  >44 publications with IL18 and Il18rap
 Cd69 antibody  >28 publications with IL18 and Cd69
 Stat3 antibody  >25 publications with IL18 and Stat3
 Il18bp antibody  >21 publications with IL18 and Il18bp
 Rela antibody  >13 publications with IL18 and Rela
 Nfkb1 antibody  >6 publications with IL18 and Nfkb1

Pathways associated with anti-IL18 antibody

 Products by Pathway  Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Hypertrophy Model Pathway antibodies  Hypertrophy Model Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram

Diseases associated with anti-IL18 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1411 publications with IL18 and Inflammation
 Necrosis Antibodies  >876 publications with IL18 and Necrosis
 Cardiovascular Diseases Antibodies  >507 publications with IL18 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >373 publications with IL18 and Kidney Diseases
 Lung Diseases Antibodies  >368 publications with IL18 and Lung Diseases
 Hypersensitivity Antibodies  >293 publications with IL18 and Hypersensitivity
 Heart Diseases Antibodies  >245 publications with IL18 and Heart Diseases
 Arthritis, Rheumatoid Antibodies  >234 publications with IL18 and Arthritis, Rheumatoid
 Hypersensitivity, Immediate Antibodies  >207 publications with IL18 and Hypersensitivity, Immediate
 Atherosclerosis Antibodies  >177 publications with IL18 and Atherosclerosis

Organs/Tissues associated with anti-IL18 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >459 publications with IL18 and Liver
 Spleen Antibodies  >299 publications with IL18 and Spleen
 Brain Antibodies  >250 publications with IL18 and Brain
 Skin Antibodies  >241 publications with IL18 and Skin
 Intestine Antibodies  >192 publications with IL18 and Intestine
 Eye Antibodies  >58 publications with IL18 and Eye
 Stomach Antibodies  >43 publications with IL18 and Stomach
 Embryonic Tissue Antibodies  >39 publications with IL18 and Embryonic Tissue
 Thymus Antibodies  >30 publications with IL18 and Thymus
 Ovary Antibodies  >29 publications with IL18 and Ovary
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