Anti-ARG1 Polyclonal Antibody – Cat# MBS178314

Anti- Liver Arginase antibody, Western blotting
All lanes: Anti Liver Arginase at 0.5ug/ml

Liver Arginase (ARG1) Antibody – Polyclonal

Name: ARG1 Antibody; Polyclonal; Rat/Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS178314
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178314

Description: Rabbit IgG polyclonal antibody for Arginase-1(ARG1) detection. Tested with WB in Human;Rat.Background: ARG1 (arginase, live) is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. The isoform encoded by… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

liver Arginase (ARG1), Polyclonal Antibody

Full Product Name

Anti-liver Arginase Antibody

Product Gene Name

anti-ARG1 antibody

Product Synonym Names

Arginase-1; A I; Al; ARG 1; ARG1; ARGI1_HUMAN; Arginase 1; Arginase liver; Arginase type I; Arginase-1; Arginase1; Liver type arginase; Liver-type arginase; Type I arginase; arginase, liver

Clonality

Polyclonal

Species Reactivity

Rat
Predicted to work with: Human

Form/Format

Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purity/Purification

Immunogen Affinity Purified

Preparation and Storage

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Molecular Weight

25,356 Da

OMIM

207800

3D Structure

ModBase 3D Structure for P05089

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human liver Arginase (64-92aa FQIVKNPRSVGKASEQLAGKVAEVKKNGR), different from the related mouse sequence by four amino acids, and from the related rat sequence by five amino acids.

Ig Type

Rabbit IgG

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-ARG1 antibody

Western Blot (WB)

Application Notes for anti-ARG1 antibody

Western Blot Concentration: 0.1-0.5ug/ml

Product References and Citations for anti-ARG1 antibody

1. Cardoso, M. L., Martins, E., Vasconcelos, R., Vilarinho, L., Rocha, J. Identification of a novel R21X mutation in the liver-type arginase gene (ARG1) in four Portuguese patients with argininemia. Hum. Mutat. 14: 355-356, 1999. 2. Grody, W. W., Dodson, A., Klein, D., Kern, R. M., Bassand, P., Cederbaum, S. D. Molecular genetic study of human arginase deficiency. (Abstract) Am. J. Hum. Genet. 45 (suppl.): A191 only, 1989. 3. Haraguchi, Y., Takiguchi, M., Amaya, Y., Kawamoto, S., Matsuda, I., Mori, M. Molecular cloning and nucleotide sequence of cDNA for human liver arginase. Proc. Nat. Acad. Sci. 84: 412-415, 1987.

Other Notes

Small volumes of anti-ARG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ARG1 purchase

MBS178314 is an antibody targeting ARG1. Also known as Anti-liver Arginase Antibody. Reactive in Rat
Predicted to work with: Human.

Additional Details

NCBI/Uniprot data below describe general gene information for ARG1. It may not necessarily be applicable to this product.

NCBI GI #

10947139

NCBI GeneID

383

NCBI Accession #

NP_000036.2

UniProt Primary Accession #

P05089

UniProt Secondary Accession #

Q5JWT5; Q5JWT6; Q8TE72; Q9BS50; A6NEA0

UniProt Related Accession #

P05089

GenBank Nucleotide #

NM_000045.3

NCBI Official Full Name

arginase-1 isoform 2

NCBI Official Synonym Full Names

arginase 1

NCBI Official Symbol

ARG1

UniProt Protein Name

Arginase-1

UniProt Synonym Protein Names

Liver-type arginase; Type I arginase

Protein Family

Arginase

UniProt Gene Name

ARG1

UniProt Entry Name

ARGI1_HUMAN

NCBI Protein Information

arginase-1

NCBI Summary for ARG1

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

UniProt Comments for ARG1

ARG1: Homotrimer. By arginine or homoarginine. Belongs to the arginase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; Amino Acid Metabolism - arginine and proline; EC 3.5.3.1

Chromosomal Location of Human Ortholog: 6q23

Cellular Component: cell soma; cytoplasm; cytosol; extracellular space; mitochondrial outer membrane; neuron projection; nucleus

Molecular Function: arginase activity; manganese ion binding

Biological Process: aging; arginine catabolic process; arginine catabolic process to ornithine; collagen biosynthetic process; liver development; lung development; mammary gland involution; maternal process involved in pregnancy; positive regulation of endothelial cell proliferation; response to amine stimulus; response to amino acid stimulus; response to axon injury; response to cadmium ion; response to drug; response to herbicide; response to manganese ion; response to methylmercury; response to selenium ion; response to vitamin A; response to vitamin E; response to zinc ion; urea cycle

Disease: Argininemia

Research Articles on ARG1

1. Arginase inhibition arrests human pulmonary artery smooth muscle cells in the G1/G0-phase under hypoxic conditions.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ARG1 antibody

Products by Pathway	Pathway Diagram
ATF-2 Transcription Factor Network Pathway antibodies	ATF-2 Transcription Factor Network Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Arginine And Proline Metabolism Pathway antibodies	Arginine And Proline Metabolism Pathway Diagram
Arginine And Proline Metabolism Pathway antibodies	Arginine And Proline Metabolism Pathway Diagram
Arginine Biosynthesis Pathway antibodies	Arginine Biosynthesis Pathway Diagram
Arginine Biosynthesis Pathway antibodies	Arginine Biosynthesis Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
IL4-mediated Signaling Events Pathway antibodies	IL4-mediated Signaling Events Pathway Diagram

Diseases associated with anti-ARG1 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>168 publications with ARG1 and Inflammation
Disease Models, Animal Antibodies	>94 publications with ARG1 and Disease Models, Animal
Lung Diseases Antibodies	>69 publications with ARG1 and Lung Diseases
Necrosis Antibodies	>53 publications with ARG1 and Necrosis
Immune System Diseases Antibodies	>49 publications with ARG1 and Immune System Diseases
Cardiovascular Diseases Antibodies	>48 publications with ARG1 and Cardiovascular Diseases
Fibrosis Antibodies	>32 publications with ARG1 and Fibrosis
Asthma Antibodies	>31 publications with ARG1 and Asthma
Liver Diseases Antibodies	>28 publications with ARG1 and Liver Diseases
Neoplasms, Experimental Antibodies	>26 publications with ARG1 and Neoplasms, Experimental

Organs/Tissues associated with anti-ARG1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>274 publications with ARG1 and Blood
Muscle Antibodies	>117 publications with ARG1 and Muscle
Lung Antibodies	>103 publications with ARG1 and Lung
Brain Antibodies	>102 publications with ARG1 and Brain
Liver Antibodies	>78 publications with ARG1 and Liver
Bone Marrow Antibodies	>53 publications with ARG1 and Bone Marrow
Spleen Antibodies	>34 publications with ARG1 and Spleen
Eye Antibodies	>28 publications with ARG1 and Eye
Skin Antibodies	>23 publications with ARG1 and Skin
Uterus Antibodies	>11 publications with ARG1 and Uterus