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IP10 Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178333

Description: Rabbit IgG polyclonal antibody for C-X-C motif chemokine 10(CXCL11) detection. Tested with WB, ELISA in Mouse.Background: C-X-C motif chemokine 10 (CXCL10), also known as Interferon gamma-induced protein 10 kDa (IP-10) or small-inducible cytokine… More details

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Product Overview

Online Datasheet in PDF
Product Name
IP10, Polyclonal Antibody
Full Product Name
Anti-IP10 Antibody
Product Gene Name
anti-IP10 antibody
Product Synonym Names
C-X-C motif chemokine 10; 10 kDa interferon gamma induced protein; 10 kDa interferon gamma-induced protein; C X C motif chemokine 10; C7; Chemokine (C X C motif) ligand 10; Chemokine CXC motif ligand 10; Crg 2; CRG2; CXCL 10; CXCL10; CXCL10(1-73); CXL10_HUMAN; Gamma IP10; Gamma-IP10; gIP 10; GIP10; IFI 10; IFI10; INP 10; INP10; Interferon activated gene 10; Interferon gamma induced cell line; Interferon inducible cytokine IP 10; Interferon inducible cytokine IP10; IP 10; IP-10; Mob 1; MOB1; Protein 10 from interferon (gamma) induced cell line; SCYB 10; SCYB10; Small inducible cytokine B10; Small inducible cytokine B10 precursor; Small inducible cytokine subfamily B (Cys X Cys) member 10; Small inducible cytokine subfamily B CXC member 10; Small-inducible cytokine B10; chemokine (C-X-C motif) ligand 10
Clonality
Polyclonal
Species Reactivity
Mouse
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen Affinity Purified
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Molecular Weight
10,789 Da
3D Structure
ModBase 3D Structure for P17515
Immunogen
E Coli-derived mouse IP10 recombinant protein (Position: I22-P98). Mouse IP10 shares 70.1% and 77.9% amino acid (aa) sequence identity with human and rat IP10, respectively.
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-IP10 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-IP10 antibody
ELISA Concentration: 0.1-0.5ug/ml
Western Blot Concentration: 0.1-0.5ug/ml

Western Blot (WB) of anti-IP10 antibody

Anti- IP10 Picoband antibody, MBS178333, Western blotting
All lanes: Anti IP10 (MBS178333) at 0.5ug/ml
Lane 1: Mouse Ovary Tissue Lysate at 50ug
Lane 2: HEPA Whole Cell Lysate at 40ug
Predicted bind size: 11KD
Observed bind size: 19KD
Anti-IP10 Polyclonal Antibody – Cat# MBS178333

Product References and Citations for anti-IP10 antibody

1. Feferman, T., Maiti, P. K., Berrih-Aknin, S., Bismuth, J., Bidault, J., Fuchs, S., Souroujon, M. C.Overexpression of IFN-induced protein 10 and its receptor CXCR3 in myasthenia gravis.J. Immun.174: 5324-5331, 2005. 2. Luster AD, Unkeless JC, Ravetch JV (1985). "Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins". Nature 315 (6021): 672-6. 3. Luster AD, Jhanwar SC, Chaganti RS, Kersey JH, Ravetch JV (May 1987). "Interferon-inducible gene maps to a chromosomal band associated with a (4;11) translocation in acute leukemia cells". Proc. Natl. Acad. Sci. U.S.A. 84 (9): 2868-71.

Other Notes

Small volumes of anti-IP10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IP10 purchase

MBS178333 is an antibody targeting IP10. Reactive in Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for IP10. It may not necessarily be applicable to this product.

NCBI GI #
10946576
NCBI GeneID
15945
NCBI Accession #
NP_067249.1
UniProt Primary Accession #
P17515
UniProt Related Accession #
P17515
GenBank Nucleotide #
NM_021274.2
NCBI Official Full Name
C-X-C motif chemokine 10
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 10
NCBI Official Symbol
Cxcl10
NCBI Official Synonym Symbols
C7; IP10; CRG-2; INP10; IP-10; Ifi10; mob-1; Scyb10; gIP-10
UniProt Protein Name
C-X-C motif chemokine 10
UniProt Synonym Protein Names
10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; C7; Interferon-gamma induced protein CRG-2; Small-inducible cytokine B10
Protein Family
C-X-C motif chemokine
UniProt Gene Name
Cxcl10
UniProt Synonym Gene Names
Crg2; Ifi10; Inp10; Scyb10; Gamma-IP10; IP-10
UniProt Entry Name
CXL10_MOUSE
NCBI Protein Information
C-X-C motif chemokine 10

UniProt Comments for IP10

CXCL10: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Chemokine; Secreted, signal peptide; Secreted

Cellular Component: external side of plasma membrane; extracellular region; extracellular space

Molecular Function: chemokine activity; CXCR chemokine receptor binding; CXCR3 chemokine receptor binding; cytokine activity; heparin binding

Biological Process: chemotaxis; defense response to virus; endothelial cell activation; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; negative regulation of angiogenesis; negative regulation of myoblast differentiation; positive regulation of cAMP metabolic process; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of leukocyte chemotaxis; positive regulation of release of sequestered calcium ion into cytosol; regulation of cell proliferation; response to lipopolysaccharide
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Research Articles on IP10

1. STAT3 in CD8+ T Cells Inhibits Their Tumor Accumulation by Downregulating CXCR3/CXCL10 Axis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IP10 antibody

 Reference Product  PubMed Publications
 Cxcl9 antibody  >1091 publications with IP10 and Cxcl9
 Cxcr3 antibody  >962 publications with IP10 and Cxcr3
 Ccl5 antibody  >748 publications with IP10 and Ccl5
 Ccr5 antibody  >193 publications with IP10 and Ccr5
 Cxcl2 antibody  >133 publications with IP10 and Cxcl2
 Ccl20 antibody  >131 publications with IP10 and Ccl20
 Cxcl5 antibody  >72 publications with IP10 and Cxcl5
 Cxcl13 antibody  >72 publications with IP10 and Cxcl13
 Cxcr5 antibody  >31 publications with IP10 and Cxcr5

Pathways associated with anti-IP10 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram

Diseases associated with anti-IP10 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1352 publications with IP10 and Inflammation
 Necrosis Antibodies  >738 publications with IP10 and Necrosis
 Disease Models, Animal Antibodies  >392 publications with IP10 and Disease Models, Animal
 Lung Diseases Antibodies  >370 publications with IP10 and Lung Diseases
 Liver Diseases Antibodies  >271 publications with IP10 and Liver Diseases
 Cardiovascular Diseases Antibodies  >204 publications with IP10 and Cardiovascular Diseases
 Fibrosis Antibodies  >145 publications with IP10 and Fibrosis
 Neoplasms, Experimental Antibodies  >109 publications with IP10 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >96 publications with IP10 and Kidney Diseases
 Lung Injury Antibodies  >67 publications with IP10 and Lung Injury

Organs/Tissues associated with anti-IP10 antibody

 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >167 publications with IP10 and Lymph Node
 Bone Marrow Antibodies  >145 publications with IP10 and Bone Marrow
 Spleen Antibodies  >144 publications with IP10 and Spleen
 Eye Antibodies  >110 publications with IP10 and Eye
 Intestine Antibodies  >101 publications with IP10 and Intestine
 Embryonic Tissue Antibodies  >57 publications with IP10 and Embryonic Tissue
 Thymus Antibodies  >55 publications with IP10 and Thymus
 Mammary Gland Antibodies  >8 publications with IP10 and Mammary Gland
 Epididymis Antibodies  >1 publications with IP10 and Epididymis
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