SCARB1 Antibody – Polyclonal

SCARB1: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester. Belongs to the CD36 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, misc.

Cellular Component: caveola; cell surface; cytoplasm; integral to membrane; integral to plasma membrane; intracellular membrane-bound organelle; lysosomal membrane; membrane; microvillus membrane; plasma membrane

Molecular Function: apolipoprotein A-I binding; apolipoprotein binding; high-density lipoprotein binding; lipopolysaccharide binding; lipopolysaccharide receptor activity; low-density lipoprotein binding; phosphatidylserine binding; protein homodimerization activity

Biological Process: adhesion to host; androgen biosynthetic process; blood vessel endothelial cell migration; cholesterol catabolic process; cholesterol efflux; cholesterol homeostasis; cholesterol transport; detection of lipopolysaccharide; endothelial cell proliferation; intestinal absorption; lipid transport; lipopolysaccharide transport; lipopolysaccharide-mediated signaling pathway; phagocytosis, recognition; phospholipid transport; positive regulation of nitric-oxide synthase activity; recognition of apoptotic cell; regulation of phagocytosis; reverse cholesterol transport