Anti-SFRP4 Polyclonal Antibody – Cat# MBS178355

Anti- SFRP4 Picoband antibody, Western blotting
All lanes: Anti SFRP4 at 0.5ug/ml
Lane 1: Rat Cardiac Muscle Tissue Lysate at 50ug
Lane 2: SKOV Whole Cell Lysate at 40ug
Predicted bind size: 40KD
Observed bind size: 40KD

SFRP4 Antibody – Polyclonal

Name: SFRP4 Antibody; Polyclonal; Human/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS178355
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS178355

Description: Rabbit IgG polyclonal antibody for Secreted frizzled-related protein 4(SFRP4) detection. Tested with WB in Human;Rat.Background: Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain… More details

$210 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SFRP4, Polyclonal Antibody

Full Product Name

Anti-SFRP4 Antibody

Product Gene Name

anti-SFRP4 antibody

Product Synonym Names

Secreted frizzled-related protein 4; Frizzled protein; Frizzled protein human endometrium; FRP 4; FRP4; FrpHE; human endometrium; Secreted frizzled-related protein 4; sFRP-4; Sfrp4; SFRP4_HUMAN; secreted frizzled-related protein 4

Clonality

Polyclonal

Species Reactivity

Human, Rat

Form/Format

Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purity/Purification

Immunogen Affinity Purified

Preparation and Storage

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Molecular Weight

39,827 Da

OMIM

606570

3D Structure

ModBase 3D Structure for Q6FHJ7

Immunogen

E Coli-derived human SFRP4 recombinant protein (Position: E140-V346). Human SFRP4 shares 90% and 90.3% amino acid (aa) sequence identity with mouse and rat SFRP4, respectively.

Ig Type

Rabbit IgG

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for anti-SFRP4 antibody

Western Blot (WB)

Application Notes for anti-SFRP4 antibody

Western Blot Concentration: 0.1-0.5ug/ml

Product References and Citations for anti-SFRP4 antibody

1. "Entrez Gene: SFRP4 secreted frizzled-related protein 4". 2. Horvath LG, Lelliott JE, Kench JG et al. (2007). "Secreted frizzled-related protein 4 inhibits proliferation and metastatic potential in prostate cancer.". Prostate 67 (10): 1081-90.

Other Notes

Small volumes of anti-SFRP4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SFRP4 purchase

MBS178355 is an antibody targeting SFRP4. Reactive in Human, Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for SFRP4. It may not necessarily be applicable to this product.

NCBI GI #

170784838

NCBI GeneID

6424

NCBI Accession #

NP_003005.2

UniProt Primary Accession #

Q6FHJ7

UniProt Secondary Accession #

O14877; Q05BG7; Q1ZYW2; Q4G124; Q6FHM0; Q6PD64; B4DYC1

UniProt Related Accession #

Q6FHJ7

GenBank Nucleotide #

NM_003014.3

NCBI Official Full Name

secreted frizzled-related protein 4

NCBI Official Synonym Full Names

secreted frizzled related protein 4

NCBI Official Symbol

SFRP4

NCBI Official Synonym Symbols

FRP-4; FRPHE; sFRP-4

UniProt Protein Name

Secreted frizzled-related protein 4

UniProt Synonym Protein Names

Frizzled protein, human endometrium; FrpHE

Protein Family

Secreted frizzled-related protein

UniProt Gene Name

SFRP4

UniProt Synonym Gene Names

FRPHE; sFRP-4; FrpHE

UniProt Entry Name

SFRP4_HUMAN

NCBI Protein Information

secreted frizzled-related protein 4

NCBI Summary for SFRP4

Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]

UniProt Comments for SFRP4

SFRP4: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. Belongs to the secreted frizzled-related protein (sFRP) family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7p14.1

Cellular Component: cell surface; cytoplasm; extracellular space; integral to membrane; nucleus

Molecular Function: G-protein coupled receptor activity; protein binding; Wnt receptor activity; Wnt-protein binding

Biological Process: cell differentiation; G-protein coupled receptor protein signaling pathway; multicellular organismal development; negative regulation of cell proliferation; negative regulation of transcription factor activity; negative regulation of Wnt receptor signaling pathway; phosphate ion homeostasis; positive regulation of apoptosis; positive regulation of epidermal cell differentiation; positive regulation of receptor internalization; response to hormone stimulus

Research Articles on SFRP4

1. sFRP4 expression is inversely related to the aggressiveness of pituitary adenomas, and acts as a tumor suppressor.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SFRP4 antibody

Products by Pathway	Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Wnt Signaling Pathway antibodies	Wnt Signaling Pathway Diagram
Wnt Signaling Pathway antibodies	Wnt Signaling Pathway Diagram
Wnt Signaling Pathway antibodies	Wnt Signaling Pathway Diagram

Diseases associated with anti-SFRP4 antibody

Disease Name	Pubmed Publications
Adenocarcinoma Antibodies	>24 publications with SFRP4 and Adenocarcinoma
Kidney Diseases Antibodies	>14 publications with SFRP4 and Kidney Diseases
Colorectal Neoplasms Antibodies	>14 publications with SFRP4 and Colorectal Neoplasms
Inflammation Antibodies	>10 publications with SFRP4 and Inflammation
Ovarian Diseases Antibodies	>10 publications with SFRP4 and Ovarian Diseases
Cell Transformation, Neoplastic Antibodies	>10 publications with SFRP4 and Cell Transformation, Neoplastic
Breast Neoplasms Antibodies	>9 publications with SFRP4 and Breast Neoplasms
Ovarian Neoplasms Antibodies	>9 publications with SFRP4 and Ovarian Neoplasms
Neoplasms, Experimental Antibodies	>8 publications with SFRP4 and Neoplasms, Experimental
Respiratory Tract Diseases Antibodies	>8 publications with SFRP4 and Respiratory Tract Diseases

Organs/Tissues associated with anti-SFRP4 antibody

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>52 publications with SFRP4 and Bone
Kidney Antibodies	>22 publications with SFRP4 and Kidney
Eye Antibodies	>22 publications with SFRP4 and Eye
Connective Tissue Antibodies	>19 publications with SFRP4 and Connective Tissue
Ovary Antibodies	>13 publications with SFRP4 and Ovary
Uterus Antibodies	>12 publications with SFRP4 and Uterus
Liver Antibodies	>11 publications with SFRP4 and Liver
Muscle Antibodies	>11 publications with SFRP4 and Muscle
Brain Antibodies	>9 publications with SFRP4 and Brain
Lung Antibodies	>9 publications with SFRP4 and Lung