EDNRB Antibody – Polyclonal

The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

ETB: a G protein-coupled receptor which activates a phosphatidylinoitol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutation in endothelin receptor type B gene. Essential component in the normal development of two neuronal crest-derived cell lineages. Two splice variant isoforms have been described.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q22

Cellular Component: cytosol; integral to plasma membrane; lipid raft; nuclear membrane; plasma membrane

Molecular Function: endothelin receptor activity; peptide hormone binding; protein binding; type 1 angiotensin receptor binding

Biological Process: aging; cell surface receptor linked signal transduction; cGMP-mediated signaling; elevation of cytosolic calcium ion concentration; enteric nervous system development; epithelial fluid transport; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); macrophage chemotaxis; melanocyte differentiation; negative regulation of adenylate cyclase activity; negative regulation of apoptosis; negative regulation of cellular protein metabolic process; negative regulation of neuron maturation; negative regulation of transcription from RNA polymerase II promoter; nervous system development; neural crest cell migration; peripheral nervous system development; positive regulation of cell proliferation; positive regulation of protein amino acid phosphorylation; posterior midgut development; regulation of blood pressure; regulation of epithelial cell proliferation; regulation of fever; regulation of pH; regulation of sensory perception of pain; response to organic cyclic substance; response to pain; sensory perception of pain; vasoconstriction; vasodilation; vein smooth muscle contraction

Disease: Abcd Syndrome; Hirschsprung Disease, Susceptibility To, 2; Waardenburg Syndrome, Type 4a